- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00568724
Urinary Biomarkers as Predictors on Renal Function in Congenital Hydronephrosis
September 13, 2012 updated by: University of Aarhus
The purpose of this study is to detect new urinary biomarkers that can be used as predictors on renal function in congenital hydronephrosis caused by unilateral ureteral obstruction (UUO) and to elucidate the pathophysiology of UUO.
Study Overview
Status
Completed
Conditions
Study Type
Observational
Enrollment (Actual)
45
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Aarhus, Denmark, 8200
- Institute of Clinical Medicine, University of Aarhus
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
3 months to 15 years (Child)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
Children referred to surgical treatment of congenital hydronephrosis caused by ureteral obstruction.
Description
Inclusion Criteria:
- Children referred to surgical treatment of congenital hydronephrosis caused by ureteral obstruction.
- Declining function of the hydronephrotic kidney more than 5 %, and to less than 40 % of the total renal function OR ipsilateral flank pain.
Exclusion Criteria:
- Bilateral hydronephrosis
- Previous operation in the urinary system except operation for phimosis and other deformations of the external genital organs.
- Deformations in the lower part of the ureter, bladder and urethra. Urinary stones. Reflux. Urinary tract infections < 6 months.
- Neurogenic bladder dysfunction.
- GFR < 40 % standardized to age.
- Non-compliance. Linguistic difficulties.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Case-Control
- Time Perspectives: Prospective
Cohorts and Interventions
Group / Cohort |
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1
Children referred to surgical treatment of congenital hydronephrosis
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2
15 age- and sex-matched controls
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Children with healthy pelvic tissue
Children referred to nephrectomy due to nephrotic syndrome
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Adults with healthy pelvic tissue
Adults referred to nephrectomy due to another cause than hydronephrosis
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Urinary cytokines
Time Frame: 1 year
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1 year
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Principal Investigator: Troels M Jørgensen, Professor, MD, Department of Urology, Aarhus University Hospital Skejby
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
November 1, 2007
Primary Completion (Actual)
January 1, 2012
Study Completion (Actual)
January 1, 2012
Study Registration Dates
First Submitted
December 5, 2007
First Submitted That Met QC Criteria
December 5, 2007
First Posted (Estimate)
December 6, 2007
Study Record Updates
Last Update Posted (Estimate)
September 14, 2012
Last Update Submitted That Met QC Criteria
September 13, 2012
Last Verified
September 1, 2012
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- MGM-01
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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