- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00664651
Joint Stiffness Following Knee Replacement Surgery
April 22, 2015 updated by: Dr. Guy Trudel, Ottawa Hospital Research Institute
Capsular Changes in Joint Contractures Post-Knee Arthroplasty:A Case-Control Study
Our primary research question is to find out whether there is a genetic component to the development of joint contractures following knee surgery, through the application of lab techniques.
Study Overview
Status
Withdrawn
Conditions
Detailed Description
After total knee replacement surgery, some people develop joint stiffness, which is also called a joint contracture.
Contractures cause the envelope of the knee (called the capsule) to stiffen and become rigid so the patient can no longer move their knee the way they used to.
After stretching and other exercises, only a surgery can try and divide or remove the contracture.
The main purpose of this research is to study the cause of the contracture and specifically if certain people are predisposed to contractures.
Study Type
Observational
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Ontario
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Ottawa, Ontario, Canada, K1Y 4E9
- Ottawa Hospital Research Institute
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
joint contractures following knee surgery
Description
Inclusion Criteria:
-knee contractures post arthroplasty scheduled for arthrotomy with debridement of capsular tissue Controls will be patients scheduled for arthrotomy with debridement of capsular tissue for the other reasons(primary knee arthroplasty, ORIF of the knee secondary to trauma, ACL repair, amputation, elective joint arthroplasty with capsuloplasty etc.)
Exclusion:
- transmissible disease (HIV, Hep B,C)
- confirmed or suspected neoplasia
- suspected infection
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Case-Control
- Time Perspectives: Retrospective
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Gene expression
Time Frame: Dec 2015
|
Dec 2015
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Guy Trudel, MD,MSc,FRCPC, OHRI / The Ottawa Hospital
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
December 1, 2006
Primary Completion (Actual)
April 1, 2015
Study Completion (Actual)
April 1, 2015
Study Registration Dates
First Submitted
April 21, 2008
First Submitted That Met QC Criteria
April 22, 2008
First Posted (Estimate)
April 23, 2008
Study Record Updates
Last Update Posted (Estimate)
April 23, 2015
Last Update Submitted That Met QC Criteria
April 22, 2015
Last Verified
April 1, 2015
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2006541
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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