- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00899340
Protein Expression in Tumor Tissue Samples From Patients With Cancer of the Oropharynx
Protein Expression Profiles in Oropharyngeal Squamous Cell Carcinoma
RATIONALE: Studying the proteins expressed in samples of tumor tissue from patients with cancer may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors plan better treatment for patients with cancer of the oropharynx.
PURPOSE: This laboratory study is looking at protein expression in tumor tissue samples from patients with cancer of the oropharynx.
Study Overview
Status
Conditions
Detailed Description
OBJECTIVES:
- To investigate if some of the differences in gene expression are also reflected at the protein level.
- To determine whether differences in gene expression that are also reflected at the protein level can be used to develop markers for early detection and disease surveillance.
- To identify targets for therapy.
OUTLINE: Archived tumor tissue samples are analyzed for expression of standard immunohistological markers (e.g., p16, p53, and Ki-67) as well as expression of genes identified in a previous gene expression study. Protein expression data are tested for clinical and demographic correlates and compared with gene expression data.
Study Type
Enrollment (Actual)
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Diagnosis of squamous cell carcinoma of the oropharynx
- Tumor tissue samples available from Vanderbilt Head and Neck Tumor Repository and Vanderbilt Pathology archives
Exclusion Criteria:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Development of biomarkers for early detection or recurrence surveillance
Time Frame: after 7 months of tissue collection
|
after 7 months of tissue collection
|
Identification of therapeutic targets and individualization of treatment based on the biology of squamous cell carcinoma of the oropharynx
Time Frame: after 7months of tissue collection
|
after 7months of tissue collection
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Study Chair: Barbara Murphy, MD, Vanderbilt-Ingram Cancer Center
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- VICC HN 0624
- VU-VICC-HN-0624
- VU-VICC-IRB-060380
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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