- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01020253
The Effectiveness of Two Osteoporosis Drugs on Prosthetic Bone Mineral Density (BMD) Loss After Total Hip Arthroplasty(THA) (ETOD)
December 2, 2009 updated by: Yokohama City University Medical Center
A Comparison of Alendronate vs. Alfacalcidol Medication for the Preservation of Bone Mineral Density Around the Femoral Implant and in the Lumbar Spine After a Total Hip Arthroplasty
The purpose of this study is to evaluate whether alendronate and alfacalcidol are effective on prosthetic or lumbar spine BMD after total hip arthroplasty.
Study Overview
Status
Unknown
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
60
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Kanagawa
-
Yokohama, Kanagawa, Japan
- Department of orthopaedic surgery, Yokohama City University
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
44 years to 82 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- osteoarthritis of the hip
- patients after total hip arthroplasty
Exclusion Criteria:
- diseases related to bone metabolism
- patients taking drugs which affect bone metabolism
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Alendronate medication
|
Alendronate: 5mg per day, Tablet, Duration is 48 weeks.
Alfacalcidol: 1μg per day, Tablet, Duration is 48 weeks.
|
Active Comparator: Alfacalcidol medication
|
Alendronate: 5mg per day, Tablet, Duration is 48 weeks.
Alfacalcidol: 1μg per day, Tablet, Duration is 48 weeks.
|
No Intervention: Non-medication
|
Alendronate: 5mg per day, Tablet, Duration is 48 weeks.
Alfacalcidol: 1μg per day, Tablet, Duration is 48 weeks.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
DEXA QDR 2000, Hologic Co.
Time Frame: 1, 12, 24 and 48 weeks after operation
|
1, 12, 24 and 48 weeks after operation
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
January 1, 2006
Primary Completion (Actual)
April 1, 2008
Study Registration Dates
First Submitted
November 24, 2009
First Submitted That Met QC Criteria
November 24, 2009
First Posted (Estimate)
November 25, 2009
Study Record Updates
Last Update Posted (Estimate)
December 3, 2009
Last Update Submitted That Met QC Criteria
December 2, 2009
Last Verified
December 1, 2009
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- YCU07-122
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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