An Epidemiological Study of Acute Coronary Syndromes in The Greek Population. The TARGET Study (TARGET)

An Epidemiological Study of Acute Coronary Syndromes in The Greek Population

This is a multicenter, 2-phase observational study of acute coronary syndromes (ACS) in Greece, designed to provide real world data on the risk factors of patients presenting to a hospital emergency department with an index event, as well as to depict the current management practices and outcomes of these clinical conditions in Greece.

Study Overview

• Status: Completed
• Conditions: Acute Coronary Syndromes

• Study Type: Observational
• Enrollment (Actual): 418

Contacts and Locations

Study Locations

• Greece
  • Chalkida, Greece
    • Research Site
  • Chios, Greece
    • Research Site
  • Attiki
    • Athens, Attiki, Greece
      • Research Site
  • Chanion
    • Chania, Chanion, Greece
      • Research Site
  • Herakliou
    • Heraklion, Herakliou, Greece
      • Research Site
  • Ioanninon
    • Ioannina, Ioanninon, Greece
      • Research Site
  • Kozani
    • Ptolemaida, Kozani, Greece
      • Research Site
  • Larrisis
    • Larissa, Larrisis, Greece
      • Research Site
  • Magnisias
    • Volos, Magnisias, Greece
      • Research Site
  • Pella
    • Eddesa, Pella, Greece
      • Research Site
  • Rodopi
    • Komotini, Rodopi, Greece
      • Research Site

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Emergency Room

Description

Inclusion Criteria:

• Diagnosis of an ACS (STEMI, NSTEMI, UA).
• Informed Consent

Exclusion Criteria:

• Involvement in the planning and conduct of the study (applies to both AstraZeneca staff and staff at the study sites).
• Participation in other clinical study in period between the index event and 6- month follow-up assessment with the exception of registering in registries or surveys not influencing the management of the ACS.

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
1; Patients over 18 years old admitted to the hospital with Acute Coronary Syndrome.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
To evaluate the proportion of patients who are on target for LDL-C according to the 2004-updated NCEP ATPIII guidelines as calculated within the first 24-hours of hospital admission for an ACS.	first visit - 1st day (cross-sectional part)
To estimate the proportion of patients enrolled in the cross-sectional part of the study that experiences a Major Adverse Cardiovascular Event (MACE) within a 6-month follow-up period.	follow up visit - 6th month (prospective part)

Secondary Outcome Measures

Outcome Measure	Time Frame
To estimate the proportion of patients admitted to the hospital with STEMI, NSTEMI and unstable angina.	first visit - 1st day (cross-sectional part)
To estimate the "pain-to-door-time" throughout different regions in Greece.	first visit - 1st day (cross-sectional part)
To estimate the time to first MACE and to estimate CV, non-CV and all cause mortality within the 6-month period following the index ACS event.	follow up visit - 6th month (prospective part)

Collaborators and Investigators

• Sponsor: AstraZeneca
• Collaborators: Hellenic Cardiovascular Research Society
• Investigators: Study Director: Panagiotis Pontikis, AstraZeneca

Study record dates

Study Major Dates

• Study Start: January 1, 2010
• Primary Completion (Actual): June 1, 2010
• Study Completion (Actual): February 1, 2011

Study Registration Dates

• First Submitted: February 1, 2010
• First Submitted That Met QC Criteria: February 1, 2010
• First Posted (Estimate): February 2, 2010

Study Record Updates

• Last Update Posted (Estimate): December 21, 2011
• Last Update Submitted That Met QC Criteria: December 20, 2011
• Last Verified: December 1, 2011

More Information

Terms related to this study

• Keywords: Epidemiology; Outcomes; Greece; Acute Coronary Syndromes; Management of disease
• Additional Relevant MeSH Terms: Pathologic Processes; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Disease; Syndrome; Acute Coronary Syndrome
• Other Study ID Numbers: NIS-CGR-DUM-2009/1