Effects of Fructose and Exercise on Hepatic Lipid Metabolism (FRUCTEXER)

October 18, 2011 updated by: Luc Tappy, MD, University of Lausanne

Effects of a Weight Maintenance, High Fructose Diet and of Exercise on Hepatic Lipid Metabolism

8 healthy male volunteers will be studied each on 3 occasions, ie

  • after 4 days on a weight maintenance diet containing 5% simple sugars + low physical activity
  • after 4 days on a weight maintenance diet containing 30% fructose + low physical activity
  • after 4 days on a weight maintenance diet containing 30% fructose + high physical activity At the end of each of these 3 periods, fructose induced hepatic de novo lipogenesis (13C palmitate synthesis in response to ingestion of a 13C fructose load) and plasma VLDL-triglyceride kinetics (measured with a bolus of 2H-labeled glycerol) will be measured

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Anticipated)

8

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Switzerland
    • VD
      • Lausanne, VD, Switzerland, CH-1011
        • Centre Hospitalier Universitaire Vaudois

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 30 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

Male

Description

Inclusion Criteria:

  • age between 18 and 30 years
  • males
  • BMI between 19 and 25
  • low to moderate physical activity (< 3 sessions/week)

Exclusion Criteria:

  • smoking
  • consumption of alcohol>50g/week
  • consumption of drugs or illicit substances
  • food allergies

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Other: Low fructose diet/no exercise
Behavioral: weight maintenance, low sugar diet
Experimental: high fructose diet/no exercise
Behavioral: weight maintenance, high fructose diet
Experimental: high fructose diet+exercise
Behavioral: weight maintenance, high fructose diet+ exercise

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Hepatic de novo lipogenesis
Time Frame: after 4 days on controlled diet+exercise
Measurement of 13C VLDL palmitate after ingestion of 13C fructose
after 4 days on controlled diet+exercise

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Plasma VLDL-triglyceride kinetics
Time Frame: after 4 days on controlled diet+exercise
Modelling of 2H5-glycerol incorporation in VLDL afetr administration of a bolus of 2H5 glycerol
after 4 days on controlled diet+exercise

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Lausanne

Collaborators

Centre Hospitalier Universitaire Vaudois

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

May 1, 2010

Primary Completion (Actual)

October 1, 2011

Study Completion (Actual)

October 1, 2011

Study Registration Dates

First Submitted

May 6, 2010

First Submitted That Met QC Criteria

May 10, 2010

First Posted (Estimate)

May 11, 2010

Study Record Updates

Last Update Posted (Estimate)

October 19, 2011

Last Update Submitted That Met QC Criteria

October 18, 2011

Last Verified

October 1, 2011

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • Protocole 220/09

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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