- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01154842
Fibroblast Growth Factor-23 (FGF-23) is Independently Associated With Left Ventricular Mass Index (LVMI) and Myocardial Performance Index (MPI) in Haemodialysis Patients
Serum Fibroblast Growth Factor-23 (FGF-23) Levels Are Independently Associated With Left Ventricular Mass and Myocardial Performance Index in Maintenance Haemodialysis Patients
Study Overview
Status
Conditions
Detailed Description
Fibroblast growth factor 23 (FGF-23) is a phosphorus-regulating substance. Circulating FGF-23 levels increase markedly in dialysis patients and are independently associated with increased risk of mortality. Given the fact that cardiovascular disease is the leading cause of death in dialysis patients, the aim of this study was to test if elevated FGF-23 levels might be associated with left ventricular mass index (LVMI) and left ventricular index of myocardial performance (MPI) in maintenance haemodialysis patients.
Methods: In this cross-sectional study, plasma FGF-23 concentrations are measured using a C-terminal human enzyme-linked immunosorbent assay kit and echocardiography is performed in maintenance haemodialysis patients.
Serum FGF-23 levels will be measured in patients with a history of coronary artery disease and aortic valve calcifications.It will be searched whether patients with MPI>0.47 had higher or lower serum FGF-23 levels than those with MPI<0.47. Correlations will be examined between log FGF-23 levels and LVMI and MPI. Uni and Multivariable-adjusted regression analyses regarding whether increased log FGF-23 concentrations are independently associated with increased left ventricular mass index and increased MPI, will be performed.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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Ankara, Turkey
- Diskapi Training and Research Hospital
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Adult hemodialysis patients (age>18 years old)
Exclusion Criteria:
- Malignancy, active infection
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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Hemodialysis
Adult hemodialysis patients (age>18 years)
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
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To test if elevated FGF-23 levels might be associated with left ventricular mass index (LVMI) and left ventricular index of myocardial performance (MPI) in maintenance haemodialysis patients.
Time Frame: 7 months
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7 months
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Collaborators and Investigators
Investigators
- Study Chair: ALPER KIRKPANTUR, Assoc Prof, Diskapi Training and Research Hospital
- Study Chair: MUSTAFA BALCI, Dr, Diskapi Training and Research Hospital
- Study Chair: OGUZ GURBUZ, Dr, Diskapi Training and Research Hospital
- Study Chair: BARIS AFSAR, Dr, Zonguldak Training and Research Hospital
- Study Chair: BASOL CANBAKAN, Assoc Prof, Diskapi Training and Research Hospital
- Study Chair: RAMAZAN AKDEMIR, Assoc Prof, Diskapi Training and Research Hospital
- Study Director: DENIZ AYLI, Assoc Prof, Diskapi Training and Research Hospital
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- 1-perk
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