- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01318746
The Circadian Rhythm of Potassium and Cystatin C (Potassium)
January 11, 2018 updated by: University of Erlangen-Nürnberg Medical School
The Circadian Rhythm of Potassium and Cystatin c and the Day-to-day Variability
The potassium value is important to prevent cardiac arrhythmias and sudden cardiac death.
In patients with renal failure, the potassium value is not stable and tends to raise.
Until now there are no data available if the potassium value has a circadian rhythm and if there are individual changes from day to day.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
Potassium and cystatin c is measured every 2 hours during 24 hours, twice.
There are two groups of patients: Patients with eGFR < 60 ml/min and patients with eGFR > 60 ml/min
Study Type
Observational
Enrollment (Actual)
30
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Erlangen, Germany, 91054
- Clinical Research Unit, Department of Nephrology and Hypertension, University of Erlangen-Nürnberg
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
healthy persons compared to patients with renal failure
Description
Inclusion Criteria:
- at least 18 years old
- normal renal function and impaired renal function (GFR < 60 ml/min) respectively
Exclusion Criteria:
- pregnancy
- anaemia (Hb<10 mg/dl)
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Healthy group
15 persons with normal renal function
|
blood withdrawal every 2 hours during 24 hours
|
Renal failure
15 persons with renal failure (GFR < 60 ml/min)
|
blood withdrawal every 2 hours during 24 hours
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Potassium rhythm
Time Frame: twice in 24 hours
|
15 persons with normal renal function are hospitalized for 24 hours. Blood samples are taken every 2 hours in order to investigate the potassium value. It is repeated with 5 persons after 2 days, with 5 persons after 4 and with 5 persons after 6 days. |
twice in 24 hours
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Potassium value in renal failure
Time Frame: twice in 24 hours
|
15 persons with renal failure (GFR < 60 ml/min) are hospitalized for 24 hours.
Blood samples are taken every 2 hours in order to investigate the potassium value It is repeated with 5 persons after 2 days, with 5 persons after 4 and with 5 persons after 6 days.
|
twice in 24 hours
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Collaborators
Investigators
- Principal Investigator: Roland E. Schmieder, MD, Department of Nephrology and Hypertension, University of Erlangen-Nürnberg Medical School
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
April 1, 2011
Primary Completion (Actual)
April 1, 2013
Study Completion (Actual)
April 1, 2013
Study Registration Dates
First Submitted
March 17, 2011
First Submitted That Met QC Criteria
March 17, 2011
First Posted (Estimate)
March 18, 2011
Study Record Updates
Last Update Posted (Actual)
January 12, 2018
Last Update Submitted That Met QC Criteria
January 11, 2018
Last Verified
January 1, 2018
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 4408
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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