- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03642587
Canadian Sudden Cardiac Arrest Network (C-SCAN)
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
SCA is defined as an abrupt collapse with documented loss of vital signs,in a seemingly healthy individual and attributable to a cardiac cause. Estimates of SCA incidence vary widely from 53 to 153 per 100,000 persons/year. Most published studies use public reporting, death certificates or autopsy based registries to identify and classify SCA cases, but limited sources often result in missed cases. Prospective registries monitoring SCAs over time in large populations provide the most accurate estimation of incidence rates.
An ongoing challenge in developing effective strategies to decrease SCA are the varying definitions used to define SCA. Many published studies identify SCA as OHCA of "no obvious cause" (assumed to be a cardiac arrest due to an underlying primary cardiac cause); however, the two are not synonymous. Verifying that a particular OHCA is due to cardiac disease requires careful establishment, using data from multiple sources and case-by-case adjudication, which is difficult and not routinely performed. Accurate identification of true SCAs is crucial if we plan to implement interventions aimed to prevent them.
The Canadian Resuscitation Outcomes Consortium (CanROC) investigators are proposing to leverage experience gained from developing a sophisticated registry of all emergency medical service (EMS)-attended OHCA patients in Ontario and British Columbia (Resuscitation Outcomes Consortium - ROC 2005-2015). This registry has since been spread across Canada to include nine other provinces covering >15 million people in urban and rural communities. The proposed C-SCAN Registry will leverage and expand upon the CanROC infrastructure by augmenting its dataset to include detailed information both preceding and following the SCA event. Using this information to identify high-risk patients, we aim to implement targeted initiatives to decrease the incidence of SCA in Canada.
Objectives:
- To accurately identify and classify all possible SCA cases within the study area using new and existing data sources.
- To accurately measure the incidence and causes of SCA by age and sex.
- To measure the triggers and warning signs of SCA cases in relation to age, sex and etiology for the purposes of prediction and prevention.
- To confirm if the preliminary/pilot observations seen in southern Ontario are mirrored in other Canadian communities, both urban and rural, and in communities that are culturally and ethnically different from those in urban Toronto.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Contact
- Name: Katie Allan, PhD
- Phone Number: 40043 416-864-6060
- Email: katherine.allan@unityhealth.to
Study Locations
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Alberta
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Calgary, Alberta, Canada
- Alberta Health Services
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British Columbia
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Vancouver, British Columbia, Canada
- University of British Columbia
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Nova Scotia
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Halifax, Nova Scotia, Canada
- Emergency Health Services
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Ontario
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Ottawa, Ontario, Canada
- Ottawa Health Research Institute
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Quebec
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Montréal, Quebec, Canada
- Urgences-Sante
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Saskatchewan
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Saskatoon, Saskatchewan, Canada
- Saskatchewan Health Authority
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- All out of hospital cardiac arrest cases of "no obvious cause"
- Age between 2 and 85 years
- Attended to by paramedics, and survived or died.
Exclusion Criteria:
- Patients under the age of 2 years old or older than the age of 85 years old
- Do not resuscitate orders
- Cardiac arrests with obvious causes such as trauma, anaphylaxis, sudden upper airway occlusion, asthma, confirmed drug overdoses, homicides and suicides.
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Study Population
People between the ages of 2 and 85 years old with out of hospital cardiac arrest of no obvious cause who are attended to by paramedics who survive or die
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There is no intervention in this study.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Incidence of SCA
Time Frame: 2 years
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Incidence of sudden cardiac arrest across Canada, by province, age and sex
|
2 years
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Steve S Lin, MD, MSc, Unity Health Toronto
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Estimated)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- CSCAN version 2
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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