Internet-based Cognitive Behavior Therapy (CBT) for Obsessive Compulsive Disorder (OCD)

March 19, 2018 updated by: Karolinska Institutet

Internet-based Cognitive Behavior Therapy for Obsessive Compulsive Disorder: A Randomized Controlled Trial

Cognitive behavior therapy (CBT) is an effective treatment for obsessive compulsive disorder (OCD) but there is a lack of properly trained CBT therapists. One possible treatment alternative is Internet-based CBT (ICBT) with minimal therapist input. The aim of this study was therefore to evaluate ICBT for OCD.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

This is a randomized controlled trial with 101 participants. The control group receives support therapy on demand on the Internet.

Study Type

Interventional

Enrollment (Actual)

101

Phase

  • Phase 2

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Sweden
      • Stockholm, Sweden
        • Psykiatri Sydväst

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (ADULT, OLDER_ADULT)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Primary diagnosis of obsessive compulsive disorder (OCD)
  • At least 18 years old
  • Able to read and write in swedish
  • Computer access

Exclusion Criteria:

  • other primary diagnosis
  • substance abuse,
  • psychosis,
  • bipolar disorder,
  • suicidal ideation,
  • adjusted pharmacological treatment the last two months
  • current psychological treatment for OCD,
  • been treated with CBT the last two years,
  • serious somatic disease,
  • Y---BOCS>31
  • hoarding as primary OCD subtype

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: TREATMENT
  • Allocation: RANDOMIZED
  • Interventional Model: PARALLEL
  • Masking: SINGLE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
EXPERIMENTAL: Internet CBT
Internet-delivered CBT. Contact with therapist thru an e-mail system. 10 weeks.
Behavioral: Internet-based cognitive behavior therapy
Internet-delivered CBT. Contact with therapist thru an e-mail system. 10 weeks
PLACEBO_COMPARATOR: Support therapy
10 weeks. Therapist support contact through e-mail.
Behavioral: Support therapy on Internet
Internet-delivered support therapy. Contact with therapist thru an e-mail system. 10 weeks

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change from Baseline of obsessions and compulsions after 10 weeks and at 3- and 12 months after treatment.
Time Frame: Two weeks before treatment, 10 weeks after treatment starts, 3 and 12 months after treatment has ended
Yale Brown Obsessive Compulsive Scale (Y-BOCS)
Two weeks before treatment, 10 weeks after treatment starts, 3 and 12 months after treatment has ended

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change from Baseline of obsessions and compulsions after 10 weeks and at 3- and 12 months after treatment.
Time Frame: Two days before treatment, once per week for 10 weeks after treatment starts, 3 and 12 months after treatment has ended
Obsessive Compulsive Scale - Revised (OCI-R)
Two days before treatment, once per week for 10 weeks after treatment starts, 3 and 12 months after treatment has ended
Change from Baseline of obsessions and compulsions after 10 weeks and at 3- and 12 months after treatment.
Time Frame: Two weeks before treatment, 10 weeks after treatment starts, 3 and 12 months after the treatment has ended
Dimensional Obsessive Compulsive Scale (DOCS)
Two weeks before treatment, 10 weeks after treatment starts, 3 and 12 months after the treatment has ended
Change from Baseline of depressive symptoms after 10 weeks and at 3- and 12 months after treatment.
Time Frame: Two weeks before treatment, 10 weeks after treatment starts, 3 and 12 months after treatment has ended
Montgomery Asberg Depression Rating Scale
Two weeks before treatment, 10 weeks after treatment starts, 3 and 12 months after treatment has ended
Change from Baseline of meta cognitions after 10 weeks and at 3- and 12 months after treatment.
Time Frame: Two weeks before treatment, 10 weeks after treatment starts, 3 and 12 months after treatment has ended
Obsessive Beliefs Scale
Two weeks before treatment, 10 weeks after treatment starts, 3 and 12 months after treatment has ended
Change from Baseline of quality of life after 10 weeks and at 3- and 12 months after treatment.
Time Frame: Two weeks before treatment, 10 weeks after treatment starts, 3 and 12 months after treatment has ended
Euroqol
Two weeks before treatment, 10 weeks after treatment starts, 3 and 12 months after treatment has ended

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Karolinska Institutet

Investigators

  • Principal Investigator: Christian Rück, MD, PhD, Department of Clinical Neuroscience, KI

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (ACTUAL)

February 1, 2011

Primary Completion (ACTUAL)

June 1, 2011

Study Completion

June 1, 2011

Study Registration Dates

First Submitted

May 2, 2011

First Submitted That Met QC Criteria

May 3, 2011

First Posted (ESTIMATE)

May 4, 2011

Study Record Updates

Last Update Posted (ACTUAL)

March 21, 2018

Last Update Submitted That Met QC Criteria

March 19, 2018

Last Verified

May 1, 2011

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • OCD-S

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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