Intelligence Changes Following Minor Surgery

February 9, 2014 updated by: diansan su, RenJi Hospital

Intelligence Performance in Adolescence After Early Exposure to Anesthesia and Minor Surgery

Animal studies showed that many general anesthetics might result in neuron apoptosis and neurocognitive impairment in the developing brain. However results from human studies are conflicted. In present study, the investigators examined the association between early exposure to anesthesia and surgery for minor surgery and intelligence changes in adolescence using the Wechsler Intelligence Scale for Children.

Study Overview

Status

Withdrawn

Conditions

Study Type

Observational

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • China
      • Shanghai, China, 200127
        • Renji Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

6 years to 16 years (Child)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

Male

Sampling Method

Probability Sample

Study Population

The investigators would like chose the Children who undergone minor surgery in Renji hospital 4-6years ago and their friends who never had any surgery.

Description

Inclusion Criteria:

  1. Born from 1995
  2. Male
  3. Parents or guardian agree to attend this study
  4. Undergone minor surgery (Repair of hypospadias, phimosiectomy, cryptorchidectomy or cryptorchidopexy and repair of inguinal hernia)
  5. Children who scarify the No.1 to No.3 but no experience of any surgery.
  6. Those who undergone minor surgery in Renji Hospital 4-6years ago.

Exclusion Criteria:

  1. Any congenital central nervous system diseases
  2. Any congenital heart diseases
  3. Any congenital dysgnosia
  4. Birth weight less than 2kg
  5. Ever been hypoxic encephalopathy when birth

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Wechsler Intelligence Scale for Children
Time Frame: Average 5 years after surgery
Wechsler Intelligence Scale for Children will be done after surgery, the expected average of 5 years after surgery.
Average 5 years after surgery

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Achenbach Child Behavior Checklist
Time Frame: Average 5 years after surgery
Wechsler Intelligence Scale for Children will be done after surgery, the expected average of 5 years after surgery.
Average 5 years after surgery

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

RenJi Hospital

Collaborators

Shanghai Children's Medical Center

Investigators

  • Principal Investigator: Diansan Su, M.D., Ph.D, Renji Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

November 1, 2011

Primary Completion (Anticipated)

October 1, 2012

Study Completion (Anticipated)

December 1, 2012

Study Registration Dates

First Submitted

October 13, 2011

First Submitted That Met QC Criteria

November 29, 2011

First Posted (Estimate)

December 1, 2011

Study Record Updates

Last Update Posted (Estimate)

February 11, 2014

Last Update Submitted That Met QC Criteria

February 9, 2014

Last Verified

March 1, 2012

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • RenJiH-20111005

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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