Gender-specific aEEGs and Outcome in Preterms

Gender-related Differences in Early Amplitude-integrated Electroencephalography in Newborns < 30 Weeks' Gestational Age and Their Correlation With Neurodevelopment Outcome at Three Years Corrected Age

Background and objectives: Male sex is a risk factor for poor neurodevelopmental outcome following preterm birth. The investigators aimed to investigate gender-related differences in amplitude-integrated electroencephalography (aEEG) and to correlate these findings with neurodevelopmental outcome.

Methods: Preterm infants born <30 weeks' gestational age between 2000 and 2002 were prospectively included. aEEGs obtained within the first two weeks of life were evaluated and classified according to background activity, sleep-wake cycling (SWC) and seizure activity. Outcome was assessed at three years.

Study Overview

• Status: Completed
• Conditions: Gender Role Disorder, Male to Female Type

• Study Type: Observational
• Enrollment (Actual): 148

Contacts and Locations

Study Locations

• Austria
  • Vienna, Austria, 1090
    • Medical University of Vienna

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 5 months to 6 months (Child)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

preterms born < 30 weeks gestational age who had aEEG measurements within the first 2 weeks of life who had assessment of outcome at 3 years corrected age

Description

Inclusion Criteria:

• born<30 weeks gestational age
• who had aEEGs in first 2 weeks of life
• who were assessed for outcome at 3 years of age

Exclusion Criteria:

• born>30 weeks gestational age
• had no aEEGs in first 2 weeks of life
• lost for follow-up at 3 years

Study Plan

How is the study designed?

Collaborators and Investigators

• Sponsor: Medical University of Vienna
• Investigators: Principal Investigator: Monika Olischar, MD, Neonatology

Study record dates

Study Major Dates

• Study Start: January 1, 2000
• Primary Completion (Actual): December 1, 2002
• Study Completion (Actual): October 1, 2011

Study Registration Dates

• First Submitted: March 22, 2012
• First Submitted That Met QC Criteria: March 22, 2012
• First Posted (Estimate): March 23, 2012

Study Record Updates

• Last Update Posted (Estimate): March 23, 2012
• Last Update Submitted That Met QC Criteria: March 22, 2012
• Last Verified: March 1, 2012

More Information

Terms related to this study

• Other Study ID Numbers: gender148