Assessing the Impact of Isokinetic Muscular Strengthening in Eccentric Mode in the Medical Treatment of Knee Osteoarthritis (ISOGO)

April 16, 2026 updated by: University Hospital, Clermont-Ferrand

Assessing the Impact of Isokinetic Muscular Strengthening in Eccentric Mode in the Medical Treatment of Knee Osteoarthritis.

Knee osteoarthritis (O.A. from now on) is associated to muscular weakness of inferior limbs, especially the quadriceps; leading to disease progression. Advantages of muscular strength training for the treatment of this kind of O.A. is now well established. In this therapeutic field, isokinetic exercises seem to have a better efficiency than other, more frequently used, kinds of exercises such as isometric or isotonic exercises.

Functional impairment caused by knee O.A. is mainly affecting walking. Walking induces muscles to work in eccentric mode.

The hypothesis of this study is that muscular strengthening using isokinetic exercises in eccentric mode would have a more important benefit than isokinetic exercises in concentric mode. Such an hypothesis, if verified, could lead to a better management of rehabilitative knee exercises in the treatment of knee O.A.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Knee osteoarthritis (O.A. from now on) is associated to muscular weakness of inferior limbs, especially the quadriceps; leading to disease progression. Advantages of muscular strength training for the treatment of this kind of O.A. is now well established. In this therapeutic field, isokinetic exercises seem to have a better efficiency than other, more frequently used, kinds of exercises such as isometric or isotonic exercises.

Functional impairment caused by knee O.A. is mainly affecting walking. Walking induces muscles to work in eccentric mode.

The hypothesis of this study is that muscular strengthening using isokinetic exercises in eccentric mode would have a more important benefit than isokinetic exercises in concentric mode. Such an hypothesis, if verified, could lead to a better management of rehabilitative knee exercises in the treatment of knee O.A.

Study Type

Interventional

Enrollment (Actual)

40

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Clermont-Ferrand, France, 63003
        • Chu Clermont-Ferrand

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

36 years to 66 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Patient male or female, age ranging from 40 to 70 years old
  • Patient suffering from one-sided knee O.A. regarding criteria of the American College of Rheumatology (A.C.R.), with radiologic score ranging from 2 to 3 according to the Kellgren & Lawrence classification.
  • Patient receiving medical support
  • Patient that did not receive any infiltration on knee within two months before randomisation.
  • Patient free from any disease that could be a contraindication to the study treatment
  • Patient able to understand the protocol and willing to comply with its rules.
  • Patient willing to give consent.
  • Patient affiliated to the french social secu

Exclusion Criteria:

  • Patient carrying prosthesis.
  • Patient suffering from inflammatory arthritis, or flare of arthritis.
  • Patient suffering from symptomatic patellofemoral osteoarthritis.
  • Patient suffering from cardio-vascular or pneumologic disease that could a contraindication to the study treatment.
  • Patient suffering from any pathology that could cause muscular weakness (myopathy, neuropathy, hemiplegia...)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Other: isokinetic exercises in eccentric mode
Other: Exercise in eccentric or concentric mode
In this therapeutic field, isokinetic exercises seem to have a better efficiency than other, more frequently used, kinds of exercises such as isometric or isotonic exercises.
Other: isokinetic exercises in concentric mode
Other: Exercise in eccentric or concentric mode
In this therapeutic field, isokinetic exercises seem to have a better efficiency than other, more frequently used, kinds of exercises such as isometric or isotonic exercises.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Difference of peak torque of quadriceps
Time Frame: 6 months after treatment start
6 months after treatment start

Secondary Outcome Measures

Outcome Measure
Time Frame
Walk speed (50 meters and 200 meters)
Time Frame: at day 1, 6 weeks, and 6 months :
at day 1, 6 weeks, and 6 months :
Knee pain (via analogic visual scales)
Time Frame: at day 1, 6 weeks, and 6 months
at day 1, 6 weeks, and 6 months
Posture parameters (posturography)
Time Frame: at day 1, 6 weeks, and 6 months
at day 1, 6 weeks, and 6 months
WOMAC Scores
Time Frame: at day 1, 6 weeks, and 6 months
at day 1, 6 weeks, and 6 months
Knee perimeter
Time Frame: at day 1, 6 weeks, and 6 months
at day 1, 6 weeks, and 6 months
Knee range of motion (goniometer)
Time Frame: at day 1, 6 weeks, and 6 months
at day 1, 6 weeks, and 6 months
Kellgren & Lawrence scores
Time Frame: at day 1, 6 weeks, and 6 months
at day 1, 6 weeks, and 6 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University Hospital, Clermont-Ferrand

Investigators

  • Principal Investigator: Emmanuel COUDEYRE, University Hospital, Clermont-Ferrand

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

February 1, 2012

Primary Completion (Actual)

August 1, 2014

Study Completion (Actual)

December 31, 2018

Study Registration Dates

First Submitted

February 16, 2012

First Submitted That Met QC Criteria

April 24, 2012

First Posted (Estimated)

April 26, 2012

Study Record Updates

Last Update Posted (Actual)

April 21, 2026

Last Update Submitted That Met QC Criteria

April 16, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • CHU-0114

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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