Social Cognition in Longstanding Psychosis

In the current study, the investigators propose to measure the five domains of social cognition identified by the National Institute of Mental Health (NIMH) as relevant to individuals with psychosis (i.e., theory of mind, attribution style, emotion recognition, social perception, and social knowledge). The investigators will also explore the association between different domains of social cognition and outcomes relevant to psychotic disorder (e.g., symptomatology, social functioning, and vocational functioning).

Study Overview

• Status: Terminated
• Conditions: Schizophrenia; Schizoaffective Disorder; Major Depression With Psychotic Features; Psychosis Not Otherwise Specified (NOS); Bipolar Disorder With Psychotic Features

Detailed Description

There is growing evidence that individuals with longstanding psychotic disorders suffer from deficits in social cognition (i.e., the cognitive skills needed to successfully navigate social interactions). However, to date, there have been few attempts to measure multiple components of social cognition within the same population of individuals with psychosis. Thus, the interrelationships between various aspects of social cognition remain unclear. In the current study, the investigators propose to measure the five domains of social cognition identified by NIMH as relevant to individuals with psychosis (i.e., theory of mind, attribution style, emotion recognition, social perception, and social knowledge). The investigators will also explore the association between different domains of social cognition and outcomes relevant to psychotic disorder (e.g., symptomatology, social functioning, and vocational functioning).

• Study Type: Observational
• Enrollment (Actual): 9

Contacts and Locations

Study Locations

• United States
  • Arizona
    • Tucson, Arizona, United States, 85724
      • University of Arizona Department of Psychiatry

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 75 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Individuals with longstanding psychotic disorder (i.e., 5 years or longer in duration)

Description

Inclusion Criteria:

• Diagnosis of a schizophrenia spectrum disorder or an affective disorder with psychotic features per the Diagnostic and Statistical Manual of Mental Disorders-IV-Text Revised (DSM-IV-TR) criteria using the Structured Clinical Interview for the DSM-IV.
• Duration of psychotic symptoms greater than or equal to 5 years determined using the Symptom Onset in Schizophrenia Inventory
• Age 18-75
• No evidence of mental retardation.
• Able to provide informed consent as evidenced by passing the informed consent quiz with a score of 80% or greater.
• Fluent in English as assessed per self-report from participant

Exclusion Criteria:

• Unwilling or unable to complete study assessments (e.g., unable to read self-report questionnaires)
• Subject is currently pregnant per subject's report

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
Individuals with Longstanding Psychosis; Individuals with symptoms of psychosis that have been present for 5 or more years

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Emotion Recognition	Change from baseline to 6 month assessment in ability to recognize emotions displayed by others assessed using the Facial Emotion Identification Test	Baseline and 6 months
Attribution Style	Change from baseline to 6 month assessment in tendency to attribute events that occur to situational, personal, or internal factors assessed using the Internal, Personal, and Situational Attributions Questionnaire	Baseline and 6 months
Social Perception	Change from baseline to 6 month assessment in ability to understand concrete and abstract components of everyday social interactions assessed using the Social Cues Recognition Test	Baseline and 6 months
Social Knowledge	Change from baseline to 6 month assessment in knowledge of goals and actions associated with familiar and unfamiliar social activities assessed using the Situational Features Recognition Test	Baseline and 6 months
Theory of Mind	Change from baseline to 6 month assessment in ability to identify the mental states of other individuals assessed using the Hinting Test	Baseline and 6 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Anxiety	Change from baseline to 6 month assessment in anxiety assessed using the Beck Anxiety Inventory	Baseline and 6 months
Depression	Change from baseline to 6 month assessment in depression assessed using the Beck Depression Inventory	Baseline and 6 months
Psychosis	Change from baseline to 6 month assessment in severity of positive and negative psychotic symptoms assessed using the Positive and Negative Syndrome Scale	Baseline and 6 months
Social Functioning	Change from baseline to 6 month assessment in level of social functioning assessed using the Social Functioning Scale	Baseline and 6 months
Service Utilization	Change from baseline to 6 month assessment in utilization of medical services assessed using the Service Utilization Record Form	Baseline and 6 months
Self-Determination Needs Satisfaction	Change from baseline to 6 month assessment in ability to fulfill basic needs for autonomy, competence, and relatedness assessed using the Basic Psychological Needs Scale	Baseline and 6 months
Locus of Control	Change from baseline to 6 month assessment in perception of one's ability to control events in the environment assessed using the Multidimensional Locus of Control Scale	Baseline and 6 months
Cognitive representation of illness	Change from baseline to 6 month assessment in understanding of nature of psychotic illness assessed using the Illness Perception Questionnaire	Baseline and 6 months
Emotional Awareness	Change from baseline to 6 month assessment in awareness of one's own emotions as well as emotions of others assessed using the Levels of Emotional Awareness Scale	Baseline and 6 months
Mindfulness	Change from baseline to 6 month assessment in awareness and acceptance of feelings and events assessed using the Philadelphia Mindfulness Scale	Baseline and 6 months
Medication adherence	Change from baseline to 6 month assessment in adherence to psychiatric medication assessed using the Medication Adherence Rating Scale	Baseline and 6 months
Neuropsychological functioning	Change from baseline to 6 month assessment in neuropsychological functioning assessed using the MATRICS Consensus Cognitive Battery	Baseline and 6 months
Social Support	Change from baseline to 6 month assessment in level of social support assessed using the Measure of Perceived Support	Baseline and 6 months
Illness Uncertainty	Change from baseline to 6 month assessment in uncertainty with regard to cause, course, and treatment of illness assessed using the Mischel Uncertainty in Illness Scale	Baseline and 6 months
Relationship with familial caregivers	Change from baseline to 6 month assessment in relationship with familial caregivers assessed using the Perception of Parents Scale	Baseline and 6 months
Self-efficacy	Change from baseline to 6 month assessment in confidence with regard to control of psychotic symptoms assessed using the Self-Efficacy Scale for Schizophrenia	Baseline and 6 months
Experience of Stigma	Change from baseline to 6 month assessment in experience of stigma with regard to mental illness assessed using the Stigma Questionnaire	Baseline and 6 months
quality of life	Change from baseline to 6 month assessment in quality of life assessed using the WHO Quality of Life Scale-Brief	Baseline and 6 months
stage of recovery	Change from baseline to 6 month assessment in stage of recovery with regard to mental illness assessed using the Stages of Recovery Instrument	Baseline and 6 months
Coping skills	Change from baseline to 6 month assessment in level of coping skills assessed using the Ways of Coping Questionnaire	Baseline and 6 months
Time perspective	Change from baseline to 6 month assessment in time orientation assessed using the Zimbardo Time Perspective Instrument	Baseline and 6 months

Collaborators and Investigators

• Sponsor: University of Arizona

Study record dates

Study Major Dates

• Study Start: November 1, 2011
• Primary Completion (Actual): November 1, 2015
• Study Completion (Actual): November 1, 2015

Study Registration Dates

• First Submitted: November 7, 2011
• First Submitted That Met QC Criteria: June 18, 2012
• First Posted (Estimate): June 21, 2012

Study Record Updates

• Last Update Posted (Actual): May 21, 2020
• Last Update Submitted That Met QC Criteria: May 19, 2020
• Last Verified: May 1, 2020

More Information

Terms related to this study

• Keywords: Psychosis; schizophrenia; schizoaffective disorder; Psychosis NOS; Social Cognition; Bipolar disorder with psychotic features; Major depression with psychotic features
• Additional Relevant MeSH Terms: Behavioral Symptoms; Pathologic Processes; Mood Disorders; Schizophrenia Spectrum and Other Psychotic Disorders; Bipolar and Related Disorders; Depressive Disorder; Depression; Schizophrenia; Disease; Psychotic Disorders; Mental Disorders; Bipolar Disorder; Depressive Disorder, Major
• Other Study ID Numbers: U. Az IRB 11-0567-02