Implementing a Physical and Cognitive Performance Assessment Cohort in the MURDOCK Study Community Registry and Biorepository (PPS)

April 6, 2026 updated by: Duke University
The purpose of this study is to use the MURDOCK Horizon 1.5 infrastructure (Duke Instutional Review Board Pro00011196) to specifically target and enroll 1,000 participants across age groups and other demographic categories in order to develop a diverse cohort with specific physical and cognitive performance data paired with biological samples.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

The MURDOCK Study, proposes this Horizon 2 study to collect a brief physical and cognitive performance assessment from 1,000 MURDOCK Registry participants. Blood sample aliquots will also be obtained. These physical and cognitive performance data, paired with -omics data from plasma and serum sample analyses, offer promise in the discovery of biomarkers for functional decline. This research will provide an important basis for our understanding of the physical, lifestyle, and genetic factors which, over the lifespan, contribute to changes in physical and cognitive capabilities as we age.

Study Type

Observational

Enrollment (Actual)

1000

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • North Carolina
      • Charlotte, North Carolina, United States, 28262
        • Bethesda Health Center
      • Concord, North Carolina, United States, 28025
        • McGill Family Medicine
      • Concord, North Carolina, United States, 28205
        • Carolinas Medical Center NorthEast Medical Arts Building
      • Davidson, North Carolina, United States, 28036
        • Ada Jenkins Center
      • Harrisburg, North Carolina, United States, 28075
        • Harrisburg Sleep Center
      • Huntersville, North Carolina, United States, 28078
        • Lake Norman Community Health Clinic

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

30 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Sampling Method

Non-Probability Sample

Study Population

The study population will include 1,000 participants ages 30 and older living in Cabarrus County and/or the city of Kannapolis, or certain portions of Rowan, Mecklenburg, or Stanly counties in North Carolina.

Description

Inclusion Criteria:

  • A resident of Cabarrus County and/or the city of Kannapolis (and surrounding regions) or certain portions of Rowan, Mecklenburg, or Stanly counties in North Carolina for 6 or more months of the year.
  • Age 30 or older

Exclusion Criteria:

  • Female that is currently pregnant
  • Having had a heart attack, angina, congestive heart failure, or fluid in the lungs within the past 6 months
  • Participant that requires consent by a legally authorized representative
  • Participant that cannot walk 30ft without human assistance

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Community, Physical Performance
Genetic: Biomarker studies

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Implementing a Physical and Cognitive Performance Assessment Cohort in the MURDOCK Study Community Registry and Biorepository
Time Frame: Upto 2 years or 24 months
Factors associated with physical function and physical activity and change in physical activity and function over two-year follow-up.
Upto 2 years or 24 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Duke University

Investigators

  • Principal Investigator: Virginia Byers Kraus, MD, Ph.D., Duke University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

May 1, 2012

Primary Completion (Actual)

August 28, 2018

Study Completion (Actual)

August 28, 2018

Study Registration Dates

First Submitted

October 31, 2012

First Submitted That Met QC Criteria

October 31, 2012

First Posted (Estimated)

November 2, 2012

Study Record Updates

Last Update Posted (Actual)

April 7, 2026

Last Update Submitted That Met QC Criteria

April 6, 2026

Last Verified

January 1, 2019

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Pro00036608

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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