A Study on the Inter-Hemispheric Alpha Ratio in Kids With ADHD (SHARK) (SHARK)

Posterior Alpha Oscillations as an Index for the Attentional Bias in Children With Attentional Deficit Hyperactivity Disorder

Investigate the hypothesis that children with ADHD have difficulty with the allocation of visio-spatial attention related to an inability to control posterior alpha brain oscillations. A paradigm will be used in which the aim is to address covert attention as similar recent studies did in adults with ADHD.

Study Overview

• Status: Completed
• Conditions: ADHD

• Study Type: Observational
• Enrollment (Actual): 60

Contacts and Locations

Study Locations

• Netherlands
  • Gelderland
    • Nijmegen, Gelderland, Netherlands, 6525 EN
      • Donders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 7 years to 7 years (CHILD)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

ADHD vs no ADHD

Description

Inclusion Criteria:

For both groups

• Age between 7 and 10 years of age.
• Estimated IQ above 80.
• Psychopharmaca- naïve or -free.

For the ADHD-group - A diagnosis of ADHD, classified by the DSM-IV.

Exclusion Criteria:

• (Co-morbid) psychiatric disorder (major depression, bipolar disorder, psychotic disorder, chronically motor tic disorder or Gilles de la Tourette, Conduct disorder, autism spectrum disorder, eating disorder, anxiety disorder).
• Neurological disorders (e.g. epilepsy) currently or in the past.
• Cardiovascular disease currently or in the past.
• Serious motor or perceptual handicap.

For the no ADHD-group

- No diagnosis of ADHD, classified by the DSM-IV.

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
ADHD; A diagnosis of ADHD, classified by the DSM-IV.
no ADHD; No diagnosis of ADHD, classified by the DSM-IV.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Modualtion of alpha power	Modulation* of alpha power on congruent and incongruent trials of the covert attention task in 30 ADHD children and in 30 non-ADHD children *Modulation is the (expected) cue-induced change by a covert attention task.	Once for half an hour

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Response time on covert attention task	Time it takes to press the correct button after presentation of target-stimulus on congruent and incongruent trials of the covert attention task in 30 ADHD children and 30 non-ADHD children	Once for half an hour
Standard deviation of response time on covert attention task	The variation of the time it takes to press the correct button after presentation of target-stimulus on congruent and incongruent trials of the covert attention task in 30 ADHD children and 30 non-ADHD children	Once for half an hour
Correct responses on covert attention task	Number of correct button presses responses (i.e. same side as the target) on the covert attention task on congruent and incongruent trials of the covert attention task in 30 ADHD children and 30 non-ADHD children	Once for half an hour
Mean deviation from middle on line bisection task	Mean deviation in mm from the center of the line on the line bisection task for 30 ADHD children and 30 non-ADHD children	Once in about 5 minutes
Inattention score on the ADHD-RS-IV	The inattention subscale of the ADHD-RS-IV for 30 ADHD children and 30 non-ADHD children	Once in about 10 minutes
Hyperactivity/impulsivity score on the ADHD-RS-IV	The hyperactivity/impulsivity subscale of the ADHD-RS-IV for 30 ADHD children and 30 non-ADHD children	Once in about 10 minutes

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
FSIQ estimation	An estimate of full scale IQ, measured with 2 subtests of the WISC-III for 30 ADHD-children and 30 non-ADHD children	Once in about 20 minutes

Collaborators and Investigators

• Sponsor: Radboud University Medical Center
• Investigators: Principal Investigator: Ole Jensen, Prof, Donders Institute for Brain, Cognition and Behavior - Centre for Cognitive Neuroimaging; Principal Investigator: Jan K Buitelaar, Prof, Radboud University, Medical Centre - Donders Institute for Brain, Cognition and Behavior, Department of Cognitive Neuroscience

Study record dates

Study Major Dates

• Study Start: November 1, 2011
• Primary Completion (ACTUAL): January 1, 2015
• Study Completion (ACTUAL): January 1, 2015

Study Registration Dates

• First Submitted: August 22, 2013
• First Submitted That Met QC Criteria: August 27, 2013
• First Posted (ESTIMATE): August 30, 2013

Study Record Updates

• Last Update Posted (ESTIMATE): January 21, 2015
• Last Update Submitted That Met QC Criteria: January 19, 2015
• Last Verified: January 1, 2015

More Information

Terms related to this study

• Keywords: ADHD; Attention; Oscillation; Alpha; Lateralization
• Other Study ID Numbers: 3016038.01