Project Healthy Eating in Adults. A Study on the Health Effects of Fish Intake in Overweight Adults (FINS)

Title in Norwegian: Sunn og Frisk. En Studie av Helseeffekter av Fiskeinntak i Overvektige Voksne (FINS)

It has previously been observed that increased fish intake improves the metabolic health of overweight and obese adults, and animal protein improved metabolic health of obese rats. In this project the investigators will investigate whether increased intake of fish or meat improves metabolic health in overweight/obese adults aged 20-55 years when replacing processed food. The hypothesis is that increased intake of unprocessed fish or meat will improve metabolic health in adults as measured by glucose tolerance, lipid metabolism and inflammatory markers.

Study Overview

• Status: Completed
• Conditions: Healthy; Overweight or Obese Adults
• Intervention / Treatment: Other: Salmon Group; Other: Cod Group; Other: Meat Group

• Study Type: Interventional
• Enrollment (Actual): 183
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Norway
  • Bergen, Norway
    • University of Bergen

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 55 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• BMI > 27
• 20-55 years
• healthy

Exclusion Criteria:

• diagnosed diseases such as diabetes, CVD, intestinal diseases, arthritis
• prescription medications affecting the metabolism of glucose, lipids or the immune system
• use of supplements containing long chain n-3 fatty acids
• high intake of fish
• food allergy

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Salmon Group; Participants will eat 150g salmon for dinner, 3 times per week for 12 weeks	Other: Salmon Group
Experimental: Cod Group; Participants will eat 150g cod for dinner, 3 times per week for 12 weeks	Other: Cod Group
Active Comparator: Meat Group; Participants will eat 150g mixed meat for dinner, 3 times per week for 12 weeks	Other: Meat Group

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Changes in metabolic status (glucose, lipids, inflammation)	The effects of fish intake on glucose homeostasis, lipid metabolism and inflammation will be assessed.	Baseline and end of intervention (12 weeks)

Secondary Outcome Measures

Outcome Measure	Time Frame
Changes in plasma concentrations of amino acids and their metabolites	Baseline and end of intervention (12 weeks)
Changes in plasma concentrations of vitamins	Baseline and end of intervention (12 weeks)

Collaborators and Investigators

• Sponsor: University of Bergen
• Collaborators: The Fisheries and Aquaculture Industry Research Fund
• Investigators: Principal Investigator: Oddrun A Gudbrandsen, PhD, University of Bergen

Study record dates

Study Major Dates

• Study Start: January 1, 2014
• Primary Completion (Actual): June 1, 2015
• Study Completion (Actual): December 1, 2019

Study Registration Dates

• First Submitted: December 17, 2013
• First Submitted That Met QC Criteria: December 30, 2013
• First Posted (Estimate): January 1, 2014

Study Record Updates

• Last Update Posted (Actual): April 30, 2021
• Last Update Submitted That Met QC Criteria: April 27, 2021
• Last Verified: April 1, 2021

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Body Weight; Overweight
• Other Study ID Numbers: 2013/558