- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02113176
Minocycline as Neuroprotectant After Aneurysmal Subarachnoid Hemorrhage
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Prior to the drug:
If you decide to take part in this study, you will have a brief interview about your medical history and any medications you are taking. You will have a medical and neurological examination, CT scan and/or an angiogram to look at the blood vessel and blood supply going to the brain, and blood samples drawn for a complete blood count, chemistry analysis and cardiac enzymes (to assess any recent damage to your heart). You will have a surgery or an image guided procedure to close your aneurysm.
Additionally, during the course of the study you may be asked to have a computerized tomography (CT scan) or magnetic resonance imaging (MRI) if there is a necessity. These tests will reveal areas that might have been damaged in your brain.
Drug:
If the tests show that you qualify as a candidate for this study, you will be randomly assigned (like a flip of a coin) to have either the minocycline drug or a dummy drug that looks the same but does not have the drug in it. For the first 7 days, the drug will be given as an injection two times a day and after that for 14 days once a day by mouth. Rest of the care will be standard like in any aneurysm patient. We study the status of your blood vessel surrounding the brain with ultrasound daily to see if they have any narrowing. If the doctors find any narrowing, you will be treated to relive the narrowing. If you are discharged home at any point in the 21 days, you will be switch the oral drug and given the required drugs with instructions.
Follow up:
Before you are discharged from the hospital and at 7, 21, 30 and 90 days after the start of the drug, the following evaluations will be performed: a complete physical and neurological examinations.
As part of this study, you are required to return to the hospital or to your physician at one (1), seven (7), twenty-one (21), thirty (30), ninety (90) days after stroke onset. You will have a physical exam, a complete neurological exam. Additionally, you will be asked questions about any health problems or hospitalizations you have had since you were discharged from the hospital.
Study Type
Phase
- Phase 2
- Phase 1
Contacts and Locations
Study Locations
-
-
New York
-
Buffalo, New York, United States, 14203
- University of Buffalo Neurosurgery
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- ≥ 18 yrs of age
- Ruptured aneurysm
- Initiate treatment within 72 hours of SAH
- Pre Rankin ≤ 1
Exclusion Criteria:
- Hunt & Hess 5 with no improvement
- ICP > 30
- No plans to treat aneurysm
- Allergy to Tetracycline / Antibiotics
- Creatinine >2
- Platelets < 75,000
- Other brain diseases
- Previous infection requiring Tetracycline
Study Plan
How is the study designed?
Design Details
- Primary Purpose: TREATMENT
- Allocation: RANDOMIZED
- Interventional Model: PARALLEL
- Masking: DOUBLE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: Minocycline
|
|
PLACEBO_COMPARATOR: Placebo
200 mg IV/placebo
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
adverse event
Time Frame: 21 days
|
The primary objective of the study is to evaluate the effectiveness of minocycline in improving outcomes for patients after aneurysmal SAH. To determine the safety of minocycline 200mg/day for 21 days in the treatment arm after aneurysmal subarachnoid hemorrhage. |
21 days
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
comparative stroke scale
Time Frame: 3 months
|
To demonstrate a significant difference in outcome at 3 months as measured by NIHSS, mRS, BI and GOS in the minocycline treatment group when compared to the placebo arm. To determine any significant differences in vasospasm rates, duration of vasospasm, interventions for vasospasm, vasospasm related infarcts and delayed ischemic deficits between minocycline and placebo arms |
3 months
|
Collaborators and Investigators
Sponsor
Collaborators
Study record dates
Study Major Dates
Study Start
Primary Completion (ACTUAL)
Study Completion (ANTICIPATED)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ESTIMATE)
Study Record Updates
Last Update Posted (ACTUAL)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- MINO-SAH
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Subarachnoid Aneurysm Hemorrhage
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Assistance Publique Hopitaux De MarseilleUnknownSubarachnoid Hemorrhage (SAH) From Ruptured AneurysmFrance
-
St. Joseph's Hospital and Medical Center, PhoenixUniversity of California, San Francisco; Barrow Neurological FoundationActive, not recruitingRuptured Cerebral Aneurysm | Subarachnoid Hemorrhage (SAH)United States
-
Vascular Neurology of Southern California Inc.RecruitingAneurysm | Subarachnoid Hemorrhage, Aneurysmal | Intracranial Aneurysm | Ruptured Aneurysm | Cerebral Aneurysm UnrupturedUnited States
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Hackensack Meridian HealthRecruitingStroke | Subarachnoid Hemorrhage, Aneurysmal | Aneurysmal Subarachnoid Hemorrhage | Cerebral Aneurysm | Cerebral Ischemia | Vasospasm, CerebralUnited States
-
Changhai HospitalWuhan University; Qilu Hospital of Shandong University; The First Affiliated... and other collaboratorsUnknownSubarachnoid Hemorrhage, Aneurysmal
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Changhai HospitalUnknownSubarachnoid Hemorrhage, AneurysmalChina
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University of BergenCompletedSubarachnoid Hemorrhage, Aneurysmal | Intracranial AneurysmNorway
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University Hospital Hradec KraloveWithdrawnSubarachnoid Hemorrhage, AneurysmalCzech Republic
-
Hospital Universitari Vall d'Hebron Research InstituteNot yet recruitingSubarachnoid Hemorrhage | Subarachnoid Hemorrhage, Aneurysmal
-
University of California, Los AngelesCompletedSubarachnoid Hemorrhage | Subarachnoid Hemorrhage, Aneurysmal | Cerebral Vasospasm | Intracranial AneurysmUnited States
Clinical Trials on Minocycline
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OraPharmaCompleted
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Rempex (a wholly owned subsidiary of Melinta Therapeutics...Innovative Medicines Initiative; Universitätsklinikum KölnTerminatedRenal Insufficiency, Chronic | Healthy Subjects | Renal Insufficiency, AcuteGermany
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Johns Hopkins UniversityMakerere UniversityTerminatedHIV Infections | HIV-associated Cognitive ImpairmentUganda
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University of PittsburghTerminated
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Beijing Tiantan HospitalNeuroDawn Pharmaceutical Co., Ltd.RecruitingIschemic Stroke, AcuteChina