Can Brief High-intensity Interval Training Mitigate the Adverse Consequences of High-fat Overfeeding? (GAINHIT)

Previous research has shown that indulging in 50% more calories than required for as little as 3 days can significantly impact markers of metabolic health in lean and overweight individuals. Here, the investigators will determine if 3 brief sessions of high-intensity interval training can mitigate the adverse consequences of 7 days high-fat overfeeding in sedentary, overweight males.

Study Overview

• Status: Terminated
• Conditions: Insulin Resistance
• Intervention / Treatment: Other: Wingate HIT; Other: High-fat overfeeding; Other: Modified HIT

• Study Type: Interventional
• Enrollment (Actual): 7
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Australia
  • South Australia
    • Adelaide, South Australia, Australia, 5000
      • South Australian Health & Medical Research Institute

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 45 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• Sedentary (no more than 2 sessions of structured moderate intensity aerobic exercise or resistance training per week)
• Overweight (BMI 25-29.9 kg/m2)

Exclusion Criteria:

• Personal history of any major illness (i.e. cardiovascular disease, diabetes, hypertension, cancer, renal/liver impairments, major psychiatric disorders, eating disorders etc.)
• History of chest pain (either at rest or during exercise.)
• Abnormal resting ECG at screening visit
• Chronic use of any prescribed or non-prescribed medications (i.e. anti-hypertensive, statins, metformin, anti-inflammatories, antidepressants etc.)
• Blood pressure or blood lipids outside of reference ranges
• Serum ferritin <30ng/mL
• Uncontrolled asthma, current fever, or upper respiratory infection
• Current intake of > 140g alcohol/week
• Current smokers of cigarettes/cigars/marijuana
• Current intake of any illicit substance
• Experience claustrophobia in confined spaces
• Donated blood in the past 3 months
• Migraines
• Unable to comprehend study protocol
• Unable to perform exercise on a cycle ergometer at second screening visit

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Wingate HIT; 7 days of high-fat overfeeding (50% excess calories) in conjunction 3 supervised sessions of Wingate High-intensity Interval Training.	Other: Wingate HIT; 3 sessions of Wingate based High-Intensity Interval Training (6-8 x 15 second "all out" sprints on a cycle ergometer interspersed by 2 minutes recovery); Other: High-fat overfeeding; 7 days of high-fat overfeeding (50% excess calories)
Experimental: Modified HIT; 7 days of high-fat overfeeding (50% excess calories) in conjunction with 3 supervised sessions of Modified High-Intensity Interval Training	Other: High-fat overfeeding; 7 days of high-fat overfeeding (50% excess calories); Other: Modified HIT; 3 sessions of Modified High-Intensity Interval Training (8 x 60 second sprints at approximately 90-95% VO2 peak on a cycle ergometer interspersed by 60 seconds recovery)
Active Comparator: No Exercise Control; 7 days of high-fat overfeeding (50% excess calories) with no supervised exercise	Other: High-fat overfeeding; 7 days of high-fat overfeeding (50% excess calories)

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in glucose metabolism	Changes in insulin and glucose area under the curve assessed via 75g Oral Glucose Tolerance Test.	1 week

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in plasma levels of cytokines	Change in plasma levels of adiponectin, irisin, sex hormone-binding globulin and c-reactive protein	1 week

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in mitochondrial metabolism	Changes in citrate synthase activity, mitochondrial DNA content and protein levels of PGC-1a	1 week
Change in resting energy expenditure	Changes in resting energy expenditure measured by metabolic cart	1 week
Change in cognitive function	Changes in cognitive function, assessed by a series of computer tasks involving vigilant attention and speed processing.	1 week

Collaborators and Investigators

• Sponsor: University of Adelaide
• Collaborators: Royal Adelaide Hospital; University of South Australia

Study record dates

Study Major Dates

• Study Start: November 1, 2014
• Primary Completion (Actual): December 1, 2016
• Study Completion (Actual): December 1, 2016

Study Registration Dates

• First Submitted: June 19, 2014
• First Submitted That Met QC Criteria: June 25, 2014
• First Posted (Estimate): June 27, 2014

Study Record Updates

• Last Update Posted (Actual): May 25, 2018
• Last Update Submitted That Met QC Criteria: May 23, 2018
• Last Verified: May 1, 2018

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Glucose Metabolism Disorders; Metabolic Diseases; Hyperinsulinism; Insulin Resistance
• Other Study ID Numbers: 140319