- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02212314
Response Inhibition Training for Children With Williams Syndrome (WSRIT)
May 30, 2017 updated by: Bonita P Klein-Tasman, University of Wisconsin, Milwaukee
Developing Treatments to Improve Psychosocial Functioning in Children With Williams Syndrome Part 1: Response Inhibition Training for Children With Williams Syndrome
The investigators will conduct a pilot study investigating the effectiveness of a computerized response inhibition training program at reducing the response inhibition difficulties often seen in children with Williams syndrome ages 10-17.
The investigators hypothesize that after completing the training program, children with Williams syndrome will show improvement on computerized measures of response inhibition and on parent measures of impulsivity.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
Behavioral characteristics of individuals with Williams syndrome include eagerness to approach and interact with others (including strangers), repeated questions especially about upcoming events, and difficulties with attention, impulsivity, and inhibition.
There is very little systematic research about the kinds of interventions that are most useful for children with Williams syndrome to support optimal psychosocial functioning, and of the effectiveness of such interventions.
We will conduct a pilot study of a potential intervention to address the response inhibition difficulties associated with Williams syndrome.
The investigators will examine the utility of an online, web-based computerized cognitive retraining program aimed at addressing impulsivity and inhibition difficulties in 20 children, ages 10-17, with WS.
The engaging training program has shown some utility in other populations, including children with tic disorders and trichotillomania.
The investigators will examine the acceptability and feasibility of the treatment approach, as well as its impact on performance on experimental measures of impulsivity and on everyday psychosocial functioning as rated by parents; this study will consist of a small-scale pilot Randomized Clinical Trial with wait list.
Through this novel work, we hope to develop and tune this approach for optimal outcomes and to demonstrate the promise of this intervention to address common challenges of people with Williams syndrome in the area of inhibition.
Study Type
Interventional
Enrollment (Actual)
25
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
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Wisconsin
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Milwaukee, Wisconsin, United States, 53211
- University of Wisconsin-Milwaukee Child Neurodevelopment Research Lab
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
10 years to 17 years (CHILD)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Williams syndrome (diagnosed with genetic testing)
- Ages 10-17
- First language and main language spoken in the home is English
- Possess computer in the home that has internet access, and a second electronic device with access to Skype (e.g., smartphone, ipad, additional computer, ipod touch)
Exclusion Criteria:
- First language and main language spoken in the home is NOT English (because study measures and instructions are all in English)
- No computer in the home with internet access (because the study is being conducted via the internet)
- Comorbid severe illnesses or major surgery within the past 6 months
- Four or more previous sessions of inhibition training
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: TREATMENT
- Allocation: RANDOMIZED
- Interventional Model: CROSSOVER
- Masking: SINGLE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: Response Inhibition Training
Treatment group will receive immediate treatment after pre-test.
|
Computerized response inhibition training will be delivered via the Internet for 10 individual sessions.
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NO_INTERVENTION: Waitlist Crossover
Waitlist group will not receive intervention while treatment group is active, but waitlist group will be offered treatment after post-test is completed.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Cognitive Inhibition Tasks
Time Frame: 5-7 weeks and 3 months
|
Three measures of response inhibition that were administered to children at pre-test will be administered after the 5-7-week training and again at a 3-month follow-up.
Measures include computer-administered Motor Stroop task, Stop Signal task, and Go/No-Go Task.
|
5-7 weeks and 3 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Conners-3
Time Frame: 5-7 weeks and 3 months
|
The Conners-3 will be administered to parents at post-intervention and again at follow-up to assess changes in attention and impulsivity.
|
5-7 weeks and 3 months
|
Emotion Regulation Checklist
Time Frame: 5-7 weeks and 3 months
|
The Emotion Regulation Checklist will be administered to parents at post-intervention and follow-up to assess changes in the child's ability to regulate emotions.
|
5-7 weeks and 3 months
|
Positive and Negative Affect Scale
Time Frame: 5-7 weeks and 3 months
|
The PANAS will be administered to parents at post-intervention and follow-up to assess changes in child positive and negative affect.
|
5-7 weeks and 3 months
|
Question-Asking Questionnaire
Time Frame: 5-7 weeks and 3 months
|
The QAQ will be administered to parents at post-intervention and follow-up to assess changes in amount and frequency of child anticipatory question asking.
|
5-7 weeks and 3 months
|
Spence Children's Anxiety Scale
Time Frame: 5-7 weeks, 3 months
|
The SCAS will be administered to parents at post-intervention and follow-up to assess changes in child anxieties.
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5-7 weeks, 3 months
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MINI Kid 6.0 Parent Version
Time Frame: 5-7 weeks and 3 months
|
The MINI Kid 6.0 Parent will be administered to parents at post-intervention and follow-up to assess changes in those areas endorsed at pre-intervention.
|
5-7 weeks and 3 months
|
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Treatment Acceptability Questionnaire
Time Frame: 5-7 weeks
|
Questionnaire about study acceptability will be administered at post test after the 5-7 week training.
|
5-7 weeks
|
Treatment Evaluation Inventory
Time Frame: 5-7 weeks
|
Questionnaire evaluating treatment will be administered at post test after the 5-7 week training.
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5-7 weeks
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Bonita P Klein-Tasman, Ph.D., University of Wisconsin, Milwaukee
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
May 1, 2014
Primary Completion (ACTUAL)
May 1, 2016
Study Completion (ACTUAL)
May 1, 2016
Study Registration Dates
First Submitted
August 6, 2014
First Submitted That Met QC Criteria
August 7, 2014
First Posted (ESTIMATE)
August 8, 2014
Study Record Updates
Last Update Posted (ACTUAL)
May 31, 2017
Last Update Submitted That Met QC Criteria
May 30, 2017
Last Verified
May 1, 2017
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Pathologic Processes
- Heart Diseases
- Cardiovascular Diseases
- Nervous System Diseases
- Neurologic Manifestations
- Neurobehavioral Manifestations
- Disease
- Congenital Abnormalities
- Genetic Diseases, Inborn
- Aortic Valve Disease
- Heart Valve Diseases
- Intellectual Disability
- Chromosome Disorders
- Aortic Valve Stenosis
- Aortic Stenosis, Supravalvular
- Syndrome
- Williams Syndrome
Other Study ID Numbers
- 14.351
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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