Fat-induced Release of GLP-1 in Humans

October 9, 2014 updated by: Katrine Bagge Hansen, Glostrup University Hospital, Copenhagen

Short Fatty Acids-induced Release of GLP-1 in Humans

This study compared the incretin-releasing effect of C8-diet oil and tributyrin with that of 20 ml olive oil on a molar basis in human volunteers.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

A structured triglyceride (1,3-di-octanoyl-2-oleoyl-glycerol, called C8-diet oil), which upon digestion results in generation of two medium-chain fatty acids and 2-oleoyl-glycerol (2-OG), may lead to activation of GPR119 only, since medium fatty acids are poor agonists for fatty acid receptors.

Study Type

Interventional

Enrollment (Actual)

12

Phase

  • Not Applicable

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

16 years to 38 years (Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

Male

Description

Inclusion Criteria:

  • Caucasian healthy male subjects
  • Body mass index (BMI) 19 to 25 kg/m2
  • Informed consent

Exclusion Criteria:

  • Anaemia
  • Diabetes mellitus
  • Gastrointestinal diseases or operations interacting with intestinal absorption

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: A meal containing carrot and tributyrin
A meal containing 200 g grated carrot and 0.0216 mol tributyrin; blood test taken from 0 - 2 hours postprandial
Dietary supplement: Tributyrin
a triglyceride containing three C4-acids
Dietary supplement: Carrot
mainly water and glucose
Active Comparator: A meal containing carrot and C8-diet oil
A meal containing 200 g grated carrot and 0.0216 mol of C8-diet oil; blood test taken from 0 - 2 hours postprandial
Dietary supplement: Carrot
mainly water and glucose
Dietary supplement: C8-diet oil
a triglyceride containing 2 C8-fatty acids and one oleic acid at sn-2 position
Active Comparator: A meal containing carrot and olive oil
A meal containing 200 g grated carrot and 0.0216 mol of olive oil; blood test taken from 0 - 2 hours postprandial
Dietary supplement: Carrot
mainly water and glucose
Dietary supplement: Olive oil
a triglyceride containing mostly three oleic acids
Placebo Comparator: A meal containing carrot
A meal containing 200 g grated carrot; blood test taken from 0 - 2 hours postprandial
Dietary supplement: Carrot
mainly water and glucose

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
plasma GLP-1
Time Frame: 2 hours postprandial
2 hours postprandial
plasma GIP
Time Frame: 2 hours postprandial
2 hours postprandial

Secondary Outcome Measures

Outcome Measure
Time Frame
plasma insulin
Time Frame: 2 hours postprandial
2 hours postprandial
plasma PYY
Time Frame: 2 hours postprandial
2 hours postprandial
plasma glucose
Time Frame: 2 hours postprandial
2 hours postprandial
plasma neurotensin
Time Frame: 2 hour postprandial
2 hour postprandial
plasma CCK
Time Frame: 2 hour postprandial
2 hour postprandial

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Glostrup University Hospital, Copenhagen

Collaborators

University of Copenhagen

Investigators

  • Study Chair: Jens J Holst, Professor, Biomedical Sciences, University of Copenhagen
  • Principal Investigator: Mette J Mandøe, Student, Glostrup Hospital; Biomedical Sciences, University of Copenhagen

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

October 1, 2013

Primary Completion (Actual)

December 1, 2013

Study Completion (Actual)

February 1, 2014

Study Registration Dates

First Submitted

October 9, 2014

First Submitted That Met QC Criteria

October 9, 2014

First Posted (Estimate)

October 15, 2014

Study Record Updates

Last Update Posted (Estimate)

October 15, 2014

Last Update Submitted That Met QC Criteria

October 9, 2014

Last Verified

October 1, 2014

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • SFAS

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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