Protein Nutrition for Muscle Hypertrophy in Older Adults

December 17, 2014 updated by: Nestlé

Efficacy of Isolated Whey and Micellar Whey Protein (+/- Citrulline) to Stimulate Protein Synthesis in 'Healthy' and 'Anabolically Resistant' Elderly Muscle

The primary objective is to determine the effect of reduced activity on the stimulation of myofibrillar FSR with protein feeding in the elderly.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

The primary objective is to determine the effect of reduced activity on the stimulation of myofibrillar FSR with protein feeding in the elderly

Study Type

Interventional

Enrollment (Actual)

30

Phase

  • Not Applicable

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

65 years to 80 years (Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

Male

Description

Inclusion Criteria:

  • Must habitually complete a minimum of 5000 steps per day
  • Having obtained informed consent
  • Non-obese
  • Non-smoker

Exclusion Criteria:

  • Aged >80 years
  • Inability to comply with study procedures
  • Currently participating or having participated in another infusion trial during last 12 months
  • Any acute or chronic llness
  • History of neuromuscular problems
  • Medications known to affect protein metabolism
  • Individuals who complete fewer than 5000 steps per day
  • Individuals who have metal implants

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: 20g isolated whey protein + 30g carb, 8,5g fat, 15g glycine
Dietary supplement: isolated whey protein
isolated whey protein
Dietary supplement: glycine
glycine
Experimental: 20g micellar whey protein + 30g carb, 8.5g fat, 15g glycine
Dietary supplement: glycine
glycine
Dietary supplement: micellar whey protein
micellar whey protein
Experimental: 20g micellar whey protein + 30g carb, 8.5g fat, 5g citrulline
Dietary supplement: micellar whey protein
micellar whey protein
Dietary supplement: citrulline
citrulline

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Change in myofibrillar fractional synthetic rate (FSR)
Time Frame: one day and 2 weeks
one day and 2 weeks

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
change in non-myofibrillar fractional synthetic rate (FSR)
Time Frame: baseline and one day of feeding
baseline and one day of feeding
Capillary dilatation and blood flow
Time Frame: 2 weeks
Determine if inactivity reduces the feeding-induced increase in capillary dilation and nutrient delivery and whether citrulline rescues this in "resistant" muscle or augments it in the "healthy" muscle as measured by Definity infusion and contrast enhanced ultrasound (CEUS)
2 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Nestlé

Investigators

  • Principal Investigator: Stuart Philips, PhD, McMaster University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

September 1, 2012

Primary Completion (Actual)

December 1, 2013

Study Completion (Actual)

December 1, 2013

Study Registration Dates

First Submitted

November 12, 2014

First Submitted That Met QC Criteria

December 10, 2014

First Posted (Estimate)

December 11, 2014

Study Record Updates

Last Update Posted (Estimate)

December 18, 2014

Last Update Submitted That Met QC Criteria

December 17, 2014

Last Verified

November 1, 2014

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 11.06.NRC

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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