In Vivo Quantification of Short Chain Fatty Acids Production in the Human Colon

In Vivo Quantification of Short Chain Fatty Acids Production in the Human Colon After Consumption of Different Cereal Fractions.

During this project the amount of SCFA produced in the colon after consumption of 2 different 13C-labelled wheat fiber fractions will be quantified.

Study Overview

• Status: Completed
• Conditions: Healthy
• Intervention / Treatment: Dietary supplement: Arabinoxylan oligosaccharides; Dietary supplement: Dietary fiber enriched bran

• Study Type: Interventional
• Enrollment (Actual): 10
• Phase: Not Applicable

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 65 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Regular diet with 3 meals a day (minimal 5 times a week)
• BMI between 18.5 and 27 kg/m2

Exclusion Criteria:

• Calorie restricted diet or other special diet during the study or during the last month prior to the study
• Antibiotics in the month prior to the study
• Former surgeries on the gastrointestinal tract, with the exception of an appendectomy
• use of the following types of medications with effects on the gastrointestinal tract during the last 2 weeks prior to the study (spasmolytica, anti-diarrhea, anti-constipation, probiotics)
• Chronic disease of the gastrointestinal tract such as Crohn's disease, ulcerative colitis, irritable bowel syndrome, chronic constipation, chronic frequent diarrhea, clinically relevant lactose intolerance
• Pregnancy, pregnancy desire or breastfeeding
• Diabetes (type 1 and 2)
• Blood donation in the past 3 months prior to the study
• Abnormal hemoglobin (Hb) levels in blood, men must have a Hb level between 14.0 and 18.0 g / dL and women between 12.0 and 16.0 g / dL
• Participation in studies in the past year in which radiation was used.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Wheat derived fiber fraction 1; Arabinoxylan oligosaccharides	Dietary supplement: Arabinoxylan oligosaccharides
Experimental: Wheat derived fiber fraction 2; Dietary fiber enriched bran	Dietary supplement: Dietary fiber enriched bran

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Quantification of acetate, propionate and butyrate production in the colon after consumption of each wheat derived fiber fraction	2 years

Collaborators and Investigators

• Sponsor: KU Leuven

Study record dates

Study Major Dates

• Study Start: July 1, 2013
• Primary Completion (Actual): September 1, 2014
• Study Completion (Actual): February 1, 2015

Study Registration Dates

• First Submitted: February 27, 2015
• First Submitted That Met QC Criteria: February 27, 2015
• First Posted (Estimate): March 4, 2015

Study Record Updates

• Last Update Posted (Estimate): March 4, 2015
• Last Update Submitted That Met QC Criteria: February 27, 2015
• Last Verified: February 1, 2015

More Information

Terms related to this study

• Other Study ID Numbers: s55383