- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02456493
The Effect of Carotid IMT (Intima Media Thickness) on Postoperative Cognitive Dysfunction in Patients Undergoing Off-Pump Coronary Artery Bypass Graft Surgery
May 9, 2019 updated by: Yonsei University
The patients who have undergone cardiac surgery have higher likelihood of postoperative cognitive dysfunction (POCD).
The carotid intima-media thickness (IMT) is associated with cognitive dysfunction in the old.
The aim of this study is to evaluate the effect of carotid IMT in patients undergoing OPCAB(off-pump coronary artery bypass surgery) on postoperative cognitive dysfunction.
Two hundred twenty four patients, aged 20 to 79 years, scheduled for OPCAB will be divided into increased IMT (n=112) and normal IMT (n=112) group by preoperative B-mode ultrasonography.
The cognitive function measured by K-MMSE, MOCA-K before the operation, and on the 7 day, 3 months after operation.
The patients in the non-surgical group are measured three times: baseline, after 7days, after 3 months.
Study Overview
Status
Completed
Conditions
Study Type
Observational
Enrollment (Actual)
224
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Seoul, Korea, Republic of, 120-752
- Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
60 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
Patients who are schedued to undergo OPCAB
Description
Inclusion Criteria:
- patients who are scheduled to undergo OPCAB
Exclusion Criteria:
- severe cognitive dysfunction
- disabling mental change disorder
- unable to communicate or speak Korean
- do not have carotid IMT measurement.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Prospective
Cohorts and Interventions
Group / Cohort |
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increased carotid IMT group
Patients who have increased carotid IMT (intima media thickness)
|
normal carotid IMT group
Patients who have normal carotid IMT
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
postoperative cognitive dysfunction
Time Frame: 7 days after surgery
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7 days after surgery
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
June 29, 2015
Primary Completion (Actual)
April 8, 2019
Study Completion (Actual)
April 8, 2019
Study Registration Dates
First Submitted
May 26, 2015
First Submitted That Met QC Criteria
May 26, 2015
First Posted (Estimate)
May 28, 2015
Study Record Updates
Last Update Posted (Actual)
May 10, 2019
Last Update Submitted That Met QC Criteria
May 9, 2019
Last Verified
May 1, 2019
More Information
Terms related to this study
Other Study ID Numbers
- 4-2015-0254
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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