The Effect of Various External Pressure on Blood (EPB)

November 25, 2015 updated by: Hyub Huh

Comparison of the Effect of Various External Pressure on Blood During Rapid Infusion

Rapid infusion of blood is needed occasionally for control massive bleeding. For rapid infusion, external pressure can be used. The investigators will study correlation between external pressure and hemolysis and deformability of red blood cell.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Rapid infusion of blood is needed occasionally for control massive bleeding. For rapid infusion, external pressure can be used which cause hemolysis and alteration of red blood cell. The investigators will study correlation between variable external pressure and hemolysis and deformability of red blood cell. Differ from previous study, the investigator will use scanning electron microscope for observation red blood cell.

Study Type

Interventional

Enrollment (Actual)

25

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

20 years to 50 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • healthy volunteers, without any underlying disease.

Exclusion Criteria:

  • history of delivery, abortion in past 6 months.
  • weight : male under 50kg, female under 45kg
  • heart rate under 50 or over 100
  • fever : over 37.5
  • blood pressure : over 180/100

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Supportive Care
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: 5days
5 days after blood sampling, various external pressure test will be done. Blood wil be stored in refrigerator(Celsius 4 degree) until study day. External pressure 0, 100, 150, 200, 250, 300mmHg will be applied to each blood sample.
Device: Auto PC(Acemedical, Goyang-si, Korea) - 0mmHg(control)
Blood pass through infusion set without external pressure.
Device: Auto PC(Acemedical, Goyang-si, Korea) - 150mmHg
Blood pass through infusion set under external pressure (150mmHg)
Device: Auto PC(Acemedical, Goyang-si, Korea) - 200mmHg
Blood pass through infusion set under external pressure (200mmHg)
Device: Auto PC(Acemedical, Goyang-si, Korea) - 250mmHg
Blood pass through infusion set under external pressure (250mmHg)
Device: Auto PC(Acemedical, Goyang-si, Korea) - 300mmHg
Blood pass through infusion set under external pressure (300mmHg)
Active Comparator: 35days
35 days after blood sampling, various external pressure test will be done. Blood wil be stored in refrigerator(Celsius 4 degree) until study day. External pressure 0, 100, 150, 200, 250, 300mmHg will be applied to each blood sample.
Device: Auto PC(Acemedical, Goyang-si, Korea) - 0mmHg(control)
Blood pass through infusion set without external pressure.
Device: Auto PC(Acemedical, Goyang-si, Korea) - 150mmHg
Blood pass through infusion set under external pressure (150mmHg)
Device: Auto PC(Acemedical, Goyang-si, Korea) - 200mmHg
Blood pass through infusion set under external pressure (200mmHg)
Device: Auto PC(Acemedical, Goyang-si, Korea) - 250mmHg
Blood pass through infusion set under external pressure (250mmHg)
Device: Auto PC(Acemedical, Goyang-si, Korea) - 300mmHg
Blood pass through infusion set under external pressure (300mmHg)

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Hemolysis and alteration of deformability of red blood cell caused by external pressure
Time Frame: 1hour
1hour

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Hyub Huh

Investigators

  • Study Director: Hyub Huh, M.D., Department of anesthesiology and pain medicine, Korea University Anam Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

August 1, 2015

Primary Completion (Actual)

November 1, 2015

Study Completion (Actual)

November 1, 2015

Study Registration Dates

First Submitted

August 4, 2015

First Submitted That Met QC Criteria

August 7, 2015

First Posted (Estimate)

August 13, 2015

Study Record Updates

Last Update Posted (Estimate)

November 30, 2015

Last Update Submitted That Met QC Criteria

November 25, 2015

Last Verified

November 1, 2015

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • BP300

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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