Study of Motor Representations in Healthy Subjects and Amnestic MCI (IRMARCHE)

Walking, Brain and Functional Magnetic Resonance Imaging Study of Motor Representations in Healthy Subjects and Amnestic MCI

Walking, Brain and Functional Magnetic Resonance Imaging Study of motor representations in healthy subjects and amnesic MCI.

Study Overview

• Status: Completed
• Conditions: Mild Cognitive Impairment
• Intervention / Treatment: Radiation: Brain MRI

Detailed Description

Review and compare mapping brain activation in Magnetic Resonance Imaging about healthy subjects according to age (<40 years and> 60 years) and MCI through the combination of two paradigms: on mechanically simulated by Korvit® boots and imagination of the walk.

• Study Type: Observational
• Enrollment (Actual): 97

Contacts and Locations

Study Locations

• France
  • Pays De La Loire
    • Angers, Pays De La Loire, France, 49933
      • University Hospital Angers

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

• Healthy volunteers over 18 and under 40.
• Healthy volunteers over 60 years.
• MCI patient over 60 years

Description

Inclusion Criteria:

• Obtaining the signature of consent to participation in the study
• Age above 18 years
• Lack dementia as NICDS-ADRDA criteria
• Lack of pre-existing musculoskeletal disorders, regardless of the cause (except MCI).
• Absence of a history of stroke or other cerebrovascular disease with spinal sensorimotor sequelae.
• No cons-indication for performing a brain MRI.
• Witennses, population of young (<40 years)
• Witnesses ,population of older subjects (> 60 years)
• Witnesses Lack of MCI
• MCI patients, criteria MCI criteria according to Dubois

Exclusion Criteria :

• Refusal of MRI.
• Contraindications to brain MRI.

Study Plan

How is the study designed?

Design Details

• Observational Models: Case-Control
• Time Perspectives: Prospective

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Control subjects under 40 years; Brain MRI Simulated walking with Corvit boots Records gait parameters on Gaitrite carpet	Radiation: Brain MRI; Brain MRI (Magnetic Resonance Imaging) brain is a painless test that allows to visualize the different brain structures. Korvit, device made up of 2 shoes which reproduces the feeling to go. The Korvit® system appears possible to analyze the activated cerebral zones and to thus try to better understand the operation of the brain during walk. The GAITRite is a carpet for recording the walking operating parameters; Other Names: KORVIT; GAITRite
Control subjects over 60 years; Brain MRI Simulated walking with Corvit boots Records gait parameters on Gaitrite carpet	Radiation: Brain MRI; Brain MRI (Magnetic Resonance Imaging) brain is a painless test that allows to visualize the different brain structures. Korvit, device made up of 2 shoes which reproduces the feeling to go. The Korvit® system appears possible to analyze the activated cerebral zones and to thus try to better understand the operation of the brain during walk. The GAITRite is a carpet for recording the walking operating parameters; Other Names: KORVIT; GAITRite
MCI subjects over 60 years; Brain MRI Simulated walking with Corvit boots Records gait parameters on Gaitrite carpet	Radiation: Brain MRI; Brain MRI (Magnetic Resonance Imaging) brain is a painless test that allows to visualize the different brain structures. Korvit, device made up of 2 shoes which reproduces the feeling to go. The Korvit® system appears possible to analyze the activated cerebral zones and to thus try to better understand the operation of the brain during walk. The GAITRite is a carpet for recording the walking operating parameters; Other Names: KORVIT; GAITRite

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Review and compare mapping cerebral activation in brain MRI	Review and compare mapping brain activation in healthy about MRI according to age (<40 years and> 60 years) and MCI through the combination of two paradigms: on mechanically simulated by Korvit® boots and imagination the walk. The primary endpoint is the analysis of fMRI brain mapping in accordance with the different paradigms of acquisition. The MRI data will be the subject of a specific statistical treatment, via dedicated software, which will be implemented under the control of the investigators who have conducted such an fMRI analysis in previous studies. Various brain mapping can be established from the data collected. It may include statistical comparisons between different preselected regions, and different experimental conditions, or correlation studies between brain activation and clinical parameters.	One day

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Review and compare mapping brain activation in healthy subjects and MCI MRI in imagination alone walking.	Review and compare mapping brain activation in healthy subjects and MCI MRI in imagination alone walking. the secondary endpoint will be the analysis of spatiotemporal gait parameters	One day
Study of differences in terms of activation of brain mapping	Study of differences in terms of activation of brain mapping between mechanical stimulation task arch simulating the place of the step (pace to 120 steps per minute) and a random mechanical stimulation (not reproducing the place of the pitch) . the secondary endpoint will be the analysis of spatiotemporal gait parameters	One day
study of functional connectivity of sensorimotor cortex obtained by fMRI resting in the subject MCI.	study of functional connectivity of sensorimotor cortex obtained by fMRI resting in the subject MCI. the secondary endpoint will be the analysis of spatiotemporal gait parameters	One day
study of the potential effects on muscle activation, and autonomic nervous system	study of the potential effects on muscle activation, and autonomic nervous system of plantar mechanical stimulation reproducing walking. the secondary endpoint will be the analysis of spatiotemporal gait parameters	One day

Collaborators and Investigators

• Sponsor: University Hospital, Angers
• Investigators: Principal Investigator: Michael Dinomais, MD, UH Angers

Publications and helpful links

General Publications

• Dinomais M, Minassian AT, Tuilier T, Delion M, Wilke M, N'Guyen S, Richard I, Aube C, Menei P. Functional MRI comparison of passive and active movement: possible inhibitory role of supplementary motor area. Neuroreport. 2009 Oct 7;20(15):1351-5. doi: 10.1097/WNR.0b013e328330cd43.
• Beauchet O, Allali G, Berrut G, Hommet C, Dubost V, Assal F. Gait analysis in demented subjects: Interests and perspectives. Neuropsychiatr Dis Treat. 2008 Feb;4(1):155-60. doi: 10.2147/ndt.s2070.
• Rimmer E, Wojciechowska M, Stave C, Sganga A, O'Connell B. Implications of the Facing Dementia Survey for the general population, patients and caregivers across Europe. Int J Clin Pract Suppl. 2005 Mar;(146):17-24. doi: 10.1111/j.1368-504x.2005.00482.x.
• Ogawa S, Lee TM, Nayak AS, Glynn P. Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magn Reson Med. 1990 Apr;14(1):68-78. doi: 10.1002/mrm.1910140108.
• Beauchet O, Allali G, Launay C, Herrmann FR, Annweiler C. Gait variability at fast-pace walking speed: a biomarker of mild cognitive impairment? J Nutr Health Aging. 2013 Mar;17(3):235-9. doi: 10.1007/s12603-012-0394-4.

Study record dates

Study Major Dates

• Study Start (Actual): February 24, 2015
• Primary Completion (Actual): May 13, 2017
• Study Completion (Actual): May 13, 2017

Study Registration Dates

• First Submitted: September 18, 2015
• First Submitted That Met QC Criteria: October 8, 2015
• First Posted (Estimate): October 12, 2015

Study Record Updates

• Last Update Posted (Actual): July 12, 2021
• Last Update Submitted That Met QC Criteria: July 9, 2021
• Last Verified: July 1, 2021

More Information

Terms related to this study

• Keywords: Mild Cognitive Impairment; Magnetic Resonance Imaging
• Additional Relevant MeSH Terms: Mental Disorders; Neurocognitive Disorders; Cognition Disorders; Cognitive Dysfunction
• Other Study ID Numbers: CHU PROMOTEUR 2014/32