- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02694042
Mission is Remission®: How Can a Disease Self-management Website Change Care?
Study Overview
Status
Intervention / Treatment
Detailed Description
Background How do health care professionals help children, help themselves? How do patients become active participants in their own care? The prevalence of chronic conditions, such as IBD, is increasing in Canada [1, 2]. Health care systems need to look for sustainable and effective solutions to improve patient care while reducing health care costs. Crohn's disease (CD) and ulcerative colitis (UC), known collectively as IBD, are chronic relapsing and remitting diseases associated with significant medical (i.e., number of hospitalizations, frequent need for surgery, growth failure) and social (i.e., school absences, interference with pursuit of higher education) morbidity [3]. Medical and social morbidity of IBD are intertwined, and take a significant toll on the health-related quality of life (HRQOL) of these patients [4-6].
IBD manifests during childhood or adolescence in 20% to 25% of patients [7]. This is a crucial time in children's development, both physically [8] and emotionally [9]. Children's relationships with family and peers change significantly over the course of their childhood. Normal social development sees children seeking more emotional support from peers over family members in their adolescent years [10]. However, adolescents with IBD do not follow this pattern [11] and tend to seek continued support from family members and rely on parents' coping strategies to deal with stressors [12]. With increased reliance on family support when dealing with a chronic illness like IBD, children may be faced with additional burden when their parents' are not able to offer them the emotional support they need or do not have coping skills that are effective enough to translate into increased care for their children. Despite this, no interventions (to the authors' knowledge) to benefit psychosocial functioning have been specifically studied in pediatric patients or families with IBD.
Current medical intervention tends to focus exclusively on the disease, and does not focus on disease management and coping through self-management skills. Disease self-management involves -the interaction of health behaviours and related processes that patients and families engage in to care for a chronic disease‖ [13]. Studies in both the adult and pediatric chronic illness literature have shown that comprehensive interventions that augment medical treatments with self management therapy, lead to better medical outcomes and better quality of life than care that is strictly medically focused [4-6, 14-24]. These self-management studies are focused on chronic diseases such as diabetes, asthma and rheumatoid arthritis. There have been several small studies of psychological interventions in adult IBD patients with promising results, though issues with design limited the interpretation of the results [25-28]. Disease self-management is more than simple adherence to treatment guidelines - it also incorporates psychological and social management of living with a chronic illness.
-It's something the investigators know intuitively, but it's also supported by evidence: A child's living conditions and experiences - the determinants of health - shape his or her physical health, development, and well-being, affecting not only childhood but the foundation of their health as adults [29, 30].‖ (Stepping it up Report, pg. 23, Health Council of Canada).
Children's experiences (i.e. access to services), can be directly affected through disease self-management. Self-management training is often provided by tertiary care clinics, which includes disease education, and encouragement/support, usually at the time of diagnosis. Most care is given in concentrated sessions during crises times and is in response to a particular problem, which is not the best time to teach self-management skills. Families who are extremely distressed may, in rare cases, receive formal psychological therapy. Although most families receive excellent medical care in the tertiary care centres, the vast majority of patients do not receive comprehensive disease education and self-management therapy. Very few children with IBD receive comprehensive education and self management therapy even when they attend well organized tertiary care clinics.
Geographic and financial concerns often limit access to psychosocial care and information sessions. In most areas of Canada, psychosocial treatment is available through private care. Psychosocial treatment is available for free through public institutions (Canada Health Act, 1984); however, there are long waiting lists and significant time and financial-costs to patients. Parents would have to travel and take time from work, while children would miss school and other related activities, which may further prevent access to treatment. Many families are reluctant to see a psychologist, social worker or psychiatrist due to the social stigma attached to seeking psychotherapy. For some families, the entire process is perceived as blaming them for their problems [31].
In the past 20 years, treatments aimed at teaching parents and children to change their attitudes or behaviour have been developed and evaluated by means of rigorous, randomized trials [32-41]. Although there is strong evidence that these psychosocial treatments work in reducing symptoms and increasing health related quality of life (HRQOL), they are typically delivered only in specialty clinics by highly trained personnel. Few therapists outside of GI clinics will be knowledgeable enough about the disease to effectively help patients and families integrate their psychological and medical care. Evidence from a large meta-analysis has shown that many self-management treatments can be given with as good or better outcomes by paraprofessionals following evidence-based protocols [42]. The use of web-based programs to deliver self-management care has taken off in recent years. Recent meta-analyses have found improved behavioural outcomes for adults using web-based self-management programs [43] and improvements in symptom and disease control for youth with health conditions [44]. Web-based interventions have been found to be comparable to face-to-face treatments [45], and have demonstrated increased social support when programs utilize chat rooms. As Stinson et al. [44] state, many studies have not been able to determine the durability of treatment effects or the cost-effectiveness of these programs. The current research will attempt to address some of these shortcomings.
Based on the lack of access to disease-specific care outside of existing medical intervention, the Mission is Remission® web-based intervention program was created in 2005 as a pilot study, for use by IBD patients and their families. This is a web-enabled evidence based home program of self-management, information, and social support for pediatric IBD patients aged 12-18, with a separate site for their parents. The site was accessed on a restricted-access web site, and participants worked through the program with help of a coach. The coaches worked in collaboration with gastroenterologists, nurses and a psychologist, but the coaches were not medical professionals. This served as an adjunct to routine medical care but not as prescribed medical therapy by the patient's physician or team. This individualized, interactive 12 session program incorporated multi-media tools for disease education and psychological interventions.
The previous research program enrolled two groups of patients-those with inactive disease and those with active disease, and their parents [46]. Remission was induced in patients with active disease before beginning use of the Mission is Remission® site. Although participants demonstrated improvements in main outcome variables such as HRQOL, and Disease Knowledge, there was no true control group in this study such that statements around the effectiveness of the program in comparison to routine or standard care could not be made. Based on lessons learned from the first Mission is Remission® site, a new site was created, which was made possible from an IWK Auxiliary Grant. The expertise of the web-developer, who has been involved in the development of multiple sites for teens, was pivotal in guiding the site's development. The use of social networking, peer support, and parent-to-parent support was optimized through this process.
The proposed research plans to randomize patients to receive either comprehensive care using the Mission is Remission® site or to receive routine care (i.e. regular hospital clinic visits, appointments with clinicians and other specialists as required).
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Pediatric IBD patients (approximately 100 patients randomly assigned to the Mission is Remission® group or the wait-list control group) and one of their parents/primary caregivers;
- Patient is between 12-18 years of age, inclusive;
- Meets screening criteria for low self-efficacy;
- Signed informed consent from parent and assent from patient.
Exclusion Criteria:
- Not English speaking;
- Children with cognitive impairment.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Supportive Care
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Mission is Remission® Group
Participants in this group will be given access to the Mission is Remission® web-based teaching and support site.
They will also be emailed a link to complete online questionnaires at set time points throughout the study.
|
A web-based teaching a support program for adolescents living with inflammatory bowel disease (IBD).
|
No Intervention: Control Group
Participants in this group will continue to receive standard care without access to the Mission is Remission® website.
They will also be emailed a link to complete online questionnaires.
At the end of the 6 month study period, participants in this group will be given access to the study website.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Questionnaire to Assess Self-Efficacy - Changes from baseline
Time Frame: Baseline, 3 months and 6 months
|
Adolescents will complete a questionnaire to assess self-efficacy.
This will be done at three time points: baseline, 3 months into the study, and at 6 months (at the end of the study).
|
Baseline, 3 months and 6 months
|
Questionnaire to Assess Health Related Quality of Life - Changes from baseline
Time Frame: Baseline, 3 months and 6 months
|
Adolescents will complete the IMPACT-III questionnaire which is a health-related quality of life questionnaire for pediatric patients with inflammatory bowel disease.
The questionnaire will be completed at three time points: baseline, 3 months into the study, and at 6 months (at the end of the study).
|
Baseline, 3 months and 6 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Medication Taking Behavior Questionnaire
Time Frame: Baseline, 3 months and 6 months
|
Adolescents will complete a"Medication Taking Behavior" questionnaire to look at medication adherence in this patient population.
|
Baseline, 3 months and 6 months
|
Questionnaire to Assess Disease Activity
Time Frame: Baseline, 3 months and 6 months
|
The Pediatric Crohn's Disease Activity Index (PCDAI) (Hymans, Markowitz, Otley et al., 2005) will be used to assess disease activity in study participants who have Crohn's disease.This measure assesses disease severity, based on subjective items (e.g, patients's report of abdominal pain, stooling pattern, general well-being) and objective data (e.g.
weight and height).
The Pediatric Ulcerative Colitis Activity Index (PUCAI) (Turner, Otley, Mack et al., 2007) will be completed to assess disease activity in study participants who have ulcerative colitis.
This measure also assesses disease severity, based on subjective items (e.g, patients's report of abdominal pain, stooling pattern, general well-being).
|
Baseline, 3 months and 6 months
|
Questions to Assess Disease Knowledge
Time Frame: Over the course of 6 months (on average we expect participants in the intervention group to complete a learning module every one to two weeks)
|
Experimental group participants will answer 3-6 questions before and after the completion of each learning module in addition to 37 embedded assessment questions.
The control group will complete a subset of these questions on two occasions.
|
Over the course of 6 months (on average we expect participants in the intervention group to complete a learning module every one to two weeks)
|
Questions to Assess Physical & Social Activity Participation
Time Frame: Baseline, 3 months and 6 months
|
Questions from the 2008/2009 National Longitudinal Survey of Children and Youth were modified for use in the current study.
This includes questions on participation in school-based activities (sports, clubs, art), as well as participation in activities outside of school.
Other questions ask teenagers to report the frequency of computer use, watching television, and playing video games.
|
Baseline, 3 months and 6 months
|
Questions to Assess Transition Readiness
Time Frame: Baseline and 6 months
|
The Transition Readiness Assessment Questionnaire 5.0 will be administered to determine how ready teenagers are for adult care.
Though variance is expected as a function of age, greater gains in transition readiness are expected for intervention group participants.
|
Baseline and 6 months
|
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Economic Outcome Assessment - Questions to Assess How Having a Child with IBD Affects a Parent's Life
Time Frame: Baseline and 6 months
|
Basic questions on the degree to which having a child with IBD affects a parent's life (e.g., work productivity, ability to do regular activities) will be given to parents.
This questionnaire contains 5 items, which have been modified from The Work Productivity and Activity Impairment Questionnaire.
Other questions have been modified from Coyte and Guerriere (1998)'s Ambulatory Home Care Record, which ask parents about the time taken away from work/home to attend appointments and receive treatment for their child's IBD.
|
Baseline and 6 months
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Anthony R Otley, MD MSc, IWK Health Centre
Publications and helpful links
General Publications
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Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- MIR-1018164
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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