- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02740062
Non Invasive Brain Evaluation and Treatment for Neuropathic Pain (NIBSNP)
A Novel Non Invasive Brain EEG Based Evaluation and Treatment for Central Manifestation Characteristics of Neuropathic Pain
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Neuropathic pain is a pain which persists after nerve injury has healed and results from significant functional and structural changes in the nervous system similar to memory processes. As a result, neuropathic pain has been proposed to be "a persistence of the memory of pain and/or the inability to extinguish the memory of pain evoked by an initial inciting injury". A firm conclusion in the neurobiology of learning and memory is that different types of memory have distinct mechanisms (e.g., declarative memory vs procedural memory). A similar distinction can be made in pain: various chronic pain states have distinct central mechanisms . Accumulating evidence suggests that chronic pain is a type of nociceptive memory mediated by structural and functional plasticity in by multiple pathways at cortical, subcortical, spinal, and peripheral levels.Elucidating the basal neuronal signature of the person suffering from chronic pain enables to optimizing a treatment which in all studies was constant for all patients regardless of their basal activity
In this study participants will undergo diagnosis of the personalized central manifestation characteristics of the neuropathic pain and evaluate the efficacy of a standard, most commonly used tDCS treatment, based on the diagnosis.
for this purpose a single meeting will take place during which participants will undergo evaluation, sham treatment and standard tDCS treatment.
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Yulia Levin-Meltz
- Email: Yulia.Levin@reuth.org.il
Study Locations
-
-
Other
-
Tel Aviv, Other, Israel, 3093865
- Recruiting
- Reuth Medical Center
-
Contact:
- Yulia Levin
- Email: Yulia.Levin@reuth.org.il
-
Principal Investigator:
- Jean-Jacques Vatine., Prof.
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Neuropathic pain diagnosis by pain physician Up to 3 months before trial onset.
- Current NPRS>4
Exclusion Criteria:
- Neurological illness causing structural brain damage (e.g. Stroke, TIA)
- Psychiatric disease
- History of loss of consciousness
- Epilepsy or epilepsy in a first degree relative
- Medical implants
- Pregnancy
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Non-Randomized
- Interventional Model: Crossover Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Active treatment
Active tDCS treatment
|
|
Sham Comparator: Sham treatment
Sham tDCS treatment
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in pain as measured by VAS (visual analog scale)
Time Frame: Before and 10 minutes after one time treatment
|
VAS estimation before Treatment and 10 minutes after tDCS treatment.
|
Before and 10 minutes after one time treatment
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Von Frey sensitivity evaluation in neuropathic area
Time Frame: Before and 10 minutes after one time treatment
|
Before and 10 minutes after one time treatment
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- Reuth-01
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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