Memory and Emotion in Acute and Chronic Phases of Cerebrovascular Accident (MEMOIRE ET EMO)

September 7, 2016 updated by: Central Hospital, Nancy, France

The purpose is to determine the relationship between anxiety and cognitive performances in patients with acute and chronic phases of cerebrovascular accident (CVA). Data from neuropsychological assessment concerning cognitive processes (working and episodic memory) sensitive to different dimensions of anxiety will be analyzed.

The secondary purpose is to evaluate how some neurological (hemispherical lateralization of lesions), psychological (depression) and demographic (quality of life) variables can increase the effects of different dimensions of anxiety on cognitive processes, during the acute and/or chronic phase of CVA.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Data will be collected during usual neuropsychological evaluation and cerebral imagery examination (NIHSS, Rankin scale) of patients in acute (0-1 month) and chronic (6 months) phases of CVA.

Study Type

Observational

Enrollment (Actual)

76

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Metz, France
        • Service de Neurologie - Hôpital Bon Secours - CHR de Metz-Thionville
      • Nancy, France
        • Service de Neurologie - Hôpital Central - CHU de Nancy

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 80 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Patients hospitalized for a cerebrovascular accident

Description

Inclusion Criteria:

  • Acute phase of carotid, vertebrobasilar or lacunar cerebrovascular accident with ischemic or hemorrhagic origin
  • Right-handed
  • Possible cooperation: understanding of French instructions
  • Normal or corrected vision
  • Normal or corrected hearing
  • Mini-mental state examination score higher than pathologic threshold according to age and sociocultural level of patient
  • Possible follow up of patient

Exclusion Criteria:

  • Hearing problems
  • Vision problems
  • Right hemiplegia or acute monoparesis of right upper limb
  • Hemispatial neglect
  • Apraxia
  • Psychiatric or neurological history possibly interfering with neuropsychological evaluation
  • Important defect of working memory or executive functions

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Cohort
  • Time Perspectives: Prospective

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Patients with cerebrovascular accident
Other: Standard neuropsychological assessment
Other: Brain MRI

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
State of anxiety evaluated with STAI-YA scale
Time Frame: up to 1 month (from CVA)
up to 1 month (from CVA)
State of anxiety evaluated with STAI-YA scale
Time Frame: 6 months (from CVA)
6 months (from CVA)
Anxiety proneness evaluated with STAI-YB scale
Time Frame: up to 1 month (from CVA)
up to 1 month (from CVA)
Anxiety proneness evaluated with STAI-YB scale
Time Frame: 6 months (from CVA)
6 months (from CVA)
Apprehension anxiety evaluated with Penn State Worry Questionnaire
Time Frame: up to 1 month (from CVA)
up to 1 month (from CVA)
Apprehension anxiety evaluated with Penn State Worry Questionnaire
Time Frame: 6 months (from CVA)
6 months (from CVA)
Evaluation of working memory updating with N-back verbal and visuospatial task
Time Frame: up to 1 month (from CVA)
up to 1 month (from CVA)
Evaluation of working memory updating with N-back verbal and visuospatial task
Time Frame: 6 months (from CVA)
6 months (from CVA)
Evaluation of working memory inhibition with Stimulus-response compatibility task
Time Frame: up to 1 month (from CVA)
up to 1 month (from CVA)
Evaluation of working memory inhibition with Stimulus-response compatibility task
Time Frame: 6 months (from CVA)
6 months (from CVA)
Evaluation of working memory flexibility with Switching task
Time Frame: up to 1 month (from CVA)
up to 1 month (from CVA)
Evaluation of working memory flexibility with Switching task
Time Frame: 6 months (from CVA)
6 months (from CVA)
Evaluation of verbal working memory with Wechsler memory scale
Time Frame: up to 1 month (from CVA)
up to 1 month (from CVA)
Evaluation of verbal working memory with Wechsler memory scale
Time Frame: 6 months (from CVA)
6 months (from CVA)
Evaluation of visuospatial working memory with Wechsler memory scale
Time Frame: up to 1 month (from CVA)
up to 1 month (from CVA)
Evaluation of visuospatial working memory with Wechsler memory scale
Time Frame: 6 months (from CVA)
6 months (from CVA)
Evaluation of visual episodic memory with Rey and Taylor figure test
Time Frame: 6 months (from CVA)
6 months (from CVA)
Evaluation of verbal episodic memory with RL/RI 16 item test
Time Frame: 6 months (from CVA)
6 months (from CVA)

Secondary Outcome Measures

Outcome Measure
Time Frame
Hemispheric lateralization of lesions detected with MRI
Time Frame: up to 1 month from CVA
up to 1 month from CVA
Depression state evaluated with Back depression inventory
Time Frame: up to 1 month (from CVA)
up to 1 month (from CVA)
Depression state evaluated with Back depression inventory
Time Frame: 6 months (from CVA)
6 months (from CVA)
Quality of life evaluated with SF-36 test
Time Frame: after 6 months from CVA
after 6 months from CVA

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Central Hospital, Nancy, France

Investigators

  • Principal Investigator: Xavier DUCROCQ, Pr, Service de Neurologie - Unité Neurovasculaire - Hôpital Central Nancy

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

December 1, 2012

Primary Completion (Actual)

April 1, 2014

Study Completion (Actual)

April 1, 2014

Study Registration Dates

First Submitted

August 24, 2016

First Submitted That Met QC Criteria

August 29, 2016

First Posted (Estimate)

September 1, 2016

Study Record Updates

Last Update Posted (Estimate)

September 8, 2016

Last Update Submitted That Met QC Criteria

September 7, 2016

Last Verified

August 1, 2016

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • PSS2012/MEMOIRE-DUCROCQ/MS

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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