The Impact of the Timing of Trigger on IVF Success

The Impact of the Timing of Trigger on IVF Success: Randomized Control Trial

The aim of this study is to examine the length of ovarian stimulation with the timing of trigger in an IVF cycle and its potential to impact patient outcomes.

Study Overview

• Status: Terminated
• Conditions: Infertility; Embryonic Development; Fertilization in Vitro
• Intervention / Treatment: Other: Timing of trigger

• Study Type: Interventional
• Enrollment (Actual): 29
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Colorado
    • Lone Tree, Colorado, United States, 80124
      • Colorado Center for Reproductive Medicine

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 26 years to 44 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Female

Description

Inclusion Criteria:

• Planning to move forward with an IVF cycle
• Have met the requirements of being a patient at CCRM Colorado
• AMA: 39-44 years old And/or
• DOR: AMH < 1 & FSH >10 (age independent)

Exclusion Criteria:

• Contraindication for pregnancy
• Have not fulfilled requirements for IVF cycle
• Single gene couple or chromosomal rearrangement
• Severe male factor or testicular surgical sperm removal (need sufficient sperm for ICSI)
• One ovary
• Uterine anomalies
• Stage III or IV endometriosis
• Explained recurrent miscarriage
• PCO or PCOS
• Using donor oocyte or gestational carrier

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
No Intervention: Control group
Experimental: Testing group; Timing of trigger at end of ovarian stimulation in an IVF cycle: trigger when 2 follicles reach 18mm, OR 1 follicle reaches 18mm AND 1 follicle is between 16-18mm.	Other: Timing of trigger

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Euploid Embryos: the percentage of euploid embryos produced as analyzed by comprehensive chromosomal screening, of total embryos tested	4 weeks after egg retrieval

Secondary Outcome Measures

Outcome Measure	Time Frame
Egg maturation: the proportion of mature eggs of total number of eggs retrieved	1 week after egg retrieval
Live birth outcomes: the incidence of pregnancy resulting in live birth following embryo transfer of embryos produced by this IVF cycle	9 months after frozen embryo transfer

Collaborators and Investigators

• Sponsor: Colorado Center for Reproductive Medicine
• Collaborators: Fertility Laboratories Of Colorado
• Investigators: Study Director: Mandy Katz-Jaffe, PhD, CCRM, FLC

Study record dates

Study Major Dates

• Study Start (Actual): November 1, 2016
• Primary Completion (Actual): May 9, 2022
• Study Completion (Actual): June 15, 2022

Study Registration Dates

• First Submitted: December 6, 2016
• First Submitted That Met QC Criteria: December 9, 2016
• First Posted (Estimate): December 13, 2016

Study Record Updates

• Last Update Posted (Actual): October 14, 2022
• Last Update Submitted That Met QC Criteria: October 12, 2022
• Last Verified: October 1, 2022

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Infertility
• Other Study ID Numbers: 20160397