Post-Myocardial Infarction Patients in Santa Catarina, Brazil - Catarina Heart Study (Catarina)

Post-Myocardial Infarction Patients in Santa Catarina, Brazil: a Prospective Cohort Study - Catarina Heart Study

Prospective cohort evaluating patients in the State of Santa Catarina (Brazil) with the diagnosis of the first acute myocardial infarction from July 2016 until December 2020.

Study Overview

• Status: Active, not recruiting
• Conditions: Myocardial Infarction
• Intervention / Treatment: Other: Myocardial Infarction

• Study Type: Observational
• Enrollment (Estimated): 1426

Contacts and Locations

Study Locations

• Brazil
  • Santa Catarina
    • São José, Santa Catarina, Brazil
      • Instituto de Cardiologia de Santa Catarina

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Consecutive patients attended at the Santa Catarina Institute of Cardiology and other hospitals in the State of Santa Catarina with the diagnosis of the first acute myocardial infarction

Description

Inclusion Criteria:

• Age over 18 years;
• Presence of precordial pain suggestive of acute myocardial infarction associated with electrocardiogram with new ST segment elevation in two contiguous leads with limits: ≥0.1 mv in all leads other than leads V2-V3 where the following limits apply : ≥0.2 mv in Men ≥40 years; ≥0.25 mV in men <40 years, or ≥ 0.15 mV in women or presence of precordial pain suggestive of acute myocardial infarction associated with elevation of troponin I or CK-MB above the 99th percentile of the upper reference limit

Exclusion Criteria:

• Previous acute myocardial infarction;
• Disagreement with the Terms of Informed Consent.

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Myocardial Infarction; Patients with first myocardial Infarction	Other: Myocardial Infarction; Observational study of myocardial Infarction patients

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
MACE in 1 year	Major cardiovascular events - MACE (cardiovascular death, nonfatal infarction, unstable angina or stroke) in 1 year
MACE in 30 days	Major cardiovascular events - MACE (cardiovascular death, nonfatal infarction, unstable angina or stroke) in 30 days
Death in 1 year	Death incidence in 1 year
Death in 30 days	Death incidence in 30 days
Restenosis in 1 year	Restenosis incidence in 1 year
Restenosis in 30 days	Restenosis incidence in 30 days
Intrastent thrombosis in 1 year	Intrastent thrombosis incidence in 30 days
Intrastent thrombosis in 30 days	Intrastent thrombosis incidence in 30 days
Cardiovascular death in 1 year	Cardiovascular death incidence in 1 year
Cardiovascular death in 30 days	Cardiovascular death incidence in 30 days
Nonfatal infarction in 1 year	Nonfatal infarction incidence in 1 year
Nonfatal infarction in 30 days	Nonfatal infarction incidence in 30 days
Unstable angina in 1 year	Unstable angina incidence in 1 year
Unstable angina in 30 days	Unstable angina incidence in 30 days
Stroke in 1 year	Stroke incidence in 1 year
Stroke in 30 days	Stroke incidence in 30 days

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Epidemiological profile		Epidemiological profile of hospitalized patients with infarction in Santa Catarina at the admission
Fish consumption	Fish consumption at admission and its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction	Fish consumption at admission
Red meat consumption	Read meat consumption at admission and its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction	Red meat consumption at admission
Chocolate consumption	Red meat consumption at admission and its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction	Chocolate consumption at admission
Caffeine consumption	Caffeine consumption at admission and its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction	Caffeine consumption at admission
Alcoholic beverages consumption	Alcoholic beverages consumption at admission and its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction	Alcoholic beverages consumption at admission
Illegal drugs consumption	Illegal drugs consumption at admission and its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction	Illegal drugs consumption at admission
Cognitive level	Cognitive level (evaluated with Mini-Mental State Examination) at admission and its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction syndromes and infarction	Cognitive level at admission
Religiosity	Religiosity (evaluated with Duke University Religion Index) at admission and its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction	Religiosity at admission
Pre-infarct physical activity	Pre-infarct (evaluated with Baecke Questionnaire) physical activity at admission and its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction	Pre-infarct physical activity at admission
Depression	Depression (evaluated with PHQ-9: Patient Health Questionnaire-9) at admission and its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction	Depression at admission
Syntax score	Syntax score at admission and its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction	Syntax score at admission
TIMI frame count	TIMI frame count in patients with primary angioplasty at admission its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction	TIMI frame count in patients with primary angioplasty at admission
Ventricular function post-infarction	Ventricular function (ventricular ejection fraction), its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction	Ventricular function post-infarction (evaluated within 72 hours of admission)
Hospitalization in 1 year		Hospitalization incidence in 1 year
Hospitalization in 30 days		Hospitalization incidence in 30 days
Bleeding in 1 year		Bleeding incidence in 1 year
Bleeding in 30 days		Bleeding incidence in 30 days
Hematocrit and hemoglobin		Hematocrit and hemoglobin at the admission
Hematocrit and hemoglobin in 72 hours		Hematocrit and hemoglobin in 72 hours
Red Cell Distribution Width (RDW)		Red Cell Distribution Width (RDW) at admission
Red Cell Distribution Width (RDW)		Red Cell Distribution Width (RDW) in 72 hours
Leukocytes		Leukocytes at admission
Leukocytes		Leukocytes in 72 hours
Creatinine		Creatinine at admission
Creatinine		Creatinine in 72 hours
Troponin levels		Troponin levels at admission
Troponin levels		Troponin levels in 72 hours
Cholesterol levels		Cholesterol levels at admission
Cholesterol levels		Cholesterol levels in 72 hours
C-reactive protein		C-reactive protein at admission
C-reactive protein		C-reactive protein in 72 hours
CHA2DS2-VASc Score	CHA2DS2-VASc Score, its correlation with other evaluated parameters and its association with death, hospitalization, stroke, acute coronary syndromes and infarction	CHA2DS2-VASc Score at admission

Collaborators and Investigators

• Sponsor: Instituto de Cardiologia de Santa Catarina

Study record dates

Study Major Dates

• Study Start: July 1, 2016
• Primary Completion (Estimated): December 1, 2025
• Study Completion (Estimated): December 1, 2025

Study Registration Dates

• First Submitted: December 30, 2016
• First Submitted That Met QC Criteria: January 6, 2017
• First Posted (Estimated): January 9, 2017

Study Record Updates

• Last Update Posted (Actual): July 30, 2024
• Last Update Submitted That Met QC Criteria: July 28, 2024
• Last Verified: July 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Ischemia; Pathologic Processes; Necrosis; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Myocardial Infarction; Infarction
• Other Study ID Numbers: CAAE: 55450816.0.1001.0113

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO