Sebum Collection and Skin Barrier Function Analysis (Sebum)

April 7, 2017 updated by: University of California, Davis

Sebum Collection for Analysis and Correlation to Sebum Production, Barrier Function, and With Cutaneous and Internal Inflammatory Disease

The goal is this study is to evaluate how the skin surface lipid composition is correlated with overall sebum production, barrier function, and inflammatory disease status. We hypothesize that there will be differences in the skin surface composition among subjects of various groups:

  1. Young vs older healthy population
  2. Atopic dermatitis vs Acne vs Healthy controls
  3. Active smokers vs non-smoker controls

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

This study will be conducted through the use of painless tapes to collect lipid. These will be applied to the skin and removed. Secondly, the barrier function will be evaluated through the use of non-invasive painless devices that measure sebum, skin water loss, and skin hydration.

Study Type

Observational

Enrollment (Actual)

41

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • California
      • Sacramento, California, United States, 95816
        • UC Davis Department of Dermatology

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

12 years and older (Child, Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Study patients will be recruited from the UC Davis Department of Dermatology, UC Davis undergraduate campus, Sacramento State University, and from the greater Sacramento area.

Description

Inclusion Criteria:

  • Subjects that are 12 years of age or older

Exclusion Criteria:

  • None

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Young Age - Healthy
These subjects are between the age of 12 and 35 years. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.
Other: Skin Surface Lipid Collection and Skin Barrier Function
All five groups will undergo the same study intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.
Other Names:
  • lipid profile
  • sebum secretion rate
  • skin water loss
  • skin hydration
Old Age -Healthy
These subjects are 55 years of age and older. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.
Other: Skin Surface Lipid Collection and Skin Barrier Function
All five groups will undergo the same study intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.
Other Names:
  • lipid profile
  • sebum secretion rate
  • skin water loss
  • skin hydration
Active Smoker
These subjects are active smokers who smoke often. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.
Other: Skin Surface Lipid Collection and Skin Barrier Function
All five groups will undergo the same study intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.
Other Names:
  • lipid profile
  • sebum secretion rate
  • skin water loss
  • skin hydration
Dermatological skin condition: Acne vulgaris
These subjects have acne vulgaris. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.
Other: Skin Surface Lipid Collection and Skin Barrier Function
All five groups will undergo the same study intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.
Other Names:
  • lipid profile
  • sebum secretion rate
  • skin water loss
  • skin hydration
Dermatological skin condition: Atopic dermatitis
These subjects have atopic dermatitis. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.
Other: Skin Surface Lipid Collection and Skin Barrier Function
All five groups will undergo the same study intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.
Other Names:
  • lipid profile
  • sebum secretion rate
  • skin water loss
  • skin hydration

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Lipid Profile-aging
Time Frame: 1 day
The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin.
1 day
Lipid Profile-acne
Time Frame: 1 day
The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin.
1 day
Lipid Profile-atopic dermatitis
Time Frame: 1 day
The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin.
1 day
Lipid Profile-smoking
Time Frame: 1 day
The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin.
1 day

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Skin Barrier Function- aging
Time Frame: 1 day
The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration.
1 day
Skin Barrier Function- acne
Time Frame: 1 day
The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration.
1 day
Skin Barrier Function- atopic dermatitis
Time Frame: 1 day
The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration.
1 day
Skin Barrier Function- smoking
Time Frame: 1 day
The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration.
1 day

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of California, Davis

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

June 27, 2014

Primary Completion (Actual)

February 26, 2016

Study Completion (Actual)

February 26, 2016

Study Registration Dates

First Submitted

July 10, 2014

First Submitted That Met QC Criteria

April 7, 2017

First Posted (Actual)

April 13, 2017

Study Record Updates

Last Update Posted (Actual)

April 13, 2017

Last Update Submitted That Met QC Criteria

April 7, 2017

Last Verified

April 1, 2017

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 605131

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Smoking

Clinical Trials on Skin Surface Lipid Collection and Skin Barrier Function

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Luxembourg

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

Subscribe