Korean Cardiac Arrest Research Consortium

This study will evaluated the epidemiology and the outcomes of patients suffering out-of-hospital cardiac arrest with presumed cardiac etiology in Korea.

Study Overview

• Status: Recruiting
• Conditions: Out-of-Hospital Cardiac Arrest
• Intervention / Treatment: Other: No intervention planned

Detailed Description

The Korean Cardiac Arrest Research Consortium (KoCARC) is a collaborative research network developed to comprehend various researches conducted in the field of out-of-cardiac arrest resuscitation and to strengthen the cooperative effort in conducting studies. It was organized in 2014 with recruitment of hospitals willing to participate voluntarily to the consortium.

Not only for emergency medicine, but KoCARC is expanding the research collaboration with cardiology, preventive medicine and epidemiology as well. To enhance the professionalism and effectiveness in research, seven research committees, which consists of Epidemiology and Preventive Research Committee (EPR), Community Resuscitation Research Committee (CRR), EMS Resuscitation Research Committee (ERR), Hospital Resuscitation Research Committee (HRR), Hypothermia and Post-resuscitation Care Research Committee (HPR), Cardiac Care Resuscitation Committee (CCR) and Pediatric Resuscitation Research Committee (PRR). Also Data Safety and Monitoring Board Committee (DSMB) is organized to provide annual review and Security and Ethics Committee to oversight security and ethical issues in research. Monthly meeting of interdisciplinary steering committee, consists of the consortium chair, steering committee chair, each research committee chair and secretary committee, is held to approve the proposed research agendas and to mediate between multi-center trial participating hospitals.

KoCARC registry is a data collecting system composed of OHCA risk and prognostic variables developed to provide the platform to researches conducted in KoCARC.

• Study Type: Observational
• Enrollment (Estimated): 30000

Contacts and Locations

• Study Contact: Name: KoCARC Coordination Center; Phone Number: 82-2-2072-4052; Email: kocarc_cc@naver.com
• Study Contact Backup: Name: Yeongho Choi, MD; Phone Number: 82-10-4657-9113; Email: d2uk87@gmail.com

Study Locations

• Korea, Republic of
  • Seoul, Korea, Republic of, 03080
    • Recruiting
    • Korean Cardiac Arrest Resuscitation Consortium
    • Contact: Kyoung Jun Song, MD

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

EMS treated OHCA who visits study participating ED

Description

Inclusion Criteria:

• OHCA patients who were transported to participating emergency department (ED) by emergency medical service with resuscitation efforts and whose arrest was identified as a presumed cardiac etiology by emergency physicians in ED.

Exclusion Criteria:

• OHCA with terminal illness documented by medical record, under hospice care, with pregnancy, with pre-documented 'Do Not Resuscitate' card
• OHCA of definite non-cardiac etiology, including trauma, drowning, poisoning, burn, asphyxia, or hanging

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Survival at 6 month	Patients will be followed upon hospital discharge and up to 6 month.	6 months after cardiac arrest

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Good neurological recovery at 6 month	Good neurological recovery: Cerebral Performance Category (CPC) 1 or 2. Patients will be followed upon hospital discharge and up to 6 month.	6 months after cardiac arrest

Collaborators and Investigators

• Sponsor: Korean Cardiac Arrest Research Consortium
• Investigators: Study Chair: Sung-Pil Chung, MD, PhD, Korean Cardiac Arrest Resuscitation Consortium

Publications and helpful links

General Publications

• Jeong D, Lee GT, Park JE, Chang H, Kim T, Cha WC, Yoon H, Hwang SY, Shin TG, Sim MS, Jo I, Lee SH, Shin SD, Choi JH. Extracorporeal Life-support for Out-of-hospital Cardiac Arrest: A Nationwide Multicenter Study. Shock. 2022 May 1;57(5):680-686. doi: 10.1097/SHK.0000000000001924. Epub 2022 Mar 10.
• Kim SJ, Kim HS, Hwang SO, Jung WJ, Roh YI, Cha KC, Shin SD, Song KJ; Korean Cardiac Arrest Research Consortium (KoCARC) Investigators. Ionized calcium level at emergency department arrival is associated with return of spontaneous circulation in out-of-hospital cardiac arrest. PLoS One. 2020 Oct 12;15(10):e0240420. doi: 10.1371/journal.pone.0240420. eCollection 2020.
• Yoon JC, Kim YJ, Ahn S, Jin YH, Lee SW, Song KJ, Shin SD, Hwang SO, Kim WY; Korean Cardiac Arrest Research Consortium KoCARC. Factors for modifying the termination of resuscitation rule in out-of-hospital cardiac arrest. Am Heart J. 2019 Jul;213:73-80. doi: 10.1016/j.ahj.2019.04.003. Epub 2019 May 3.
• Lee DE, Lee MJ, Ahn JY, Ryoo HW, Park J, Kim WY, Shin SD, Hwang SO; Korean Cardiac Arrest Research Consortium (KoCARC). New Termination-of-Resuscitation Models and Prognostication in Out-of-Hospital Cardiac Arrest Using Electrocardiogram Rhythms Documented in the Field and the Emergency Department. J Korean Med Sci. 2019 May 6;34(17):e134. doi: 10.3346/jkms.2019.34.e134.

Study record dates

Study Major Dates

• Study Start (Actual): October 1, 2015
• Primary Completion (Estimated): December 31, 2028
• Study Completion (Estimated): December 31, 2028

Study Registration Dates

• First Submitted: July 6, 2017
• First Submitted That Met QC Criteria: July 17, 2017
• First Posted (Actual): July 19, 2017

Study Record Updates

• Last Update Posted (Actual): March 25, 2025
• Last Update Submitted That Met QC Criteria: March 4, 2025
• Last Verified: March 1, 2025

More Information

Terms related to this study

• Keywords: Out-of-Hospital Cardiac Arrest
• Additional Relevant MeSH Terms: Cardiovascular Diseases; Heart Diseases; Heart Arrest; Out-of-Hospital Cardiac Arrest
• Other Study ID Numbers: KoCARC

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No