- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03253068
Pembrolizumab Plus Amurubicin in Patients With Refractory Small-cell Lung Cancer
May 18, 2020 updated by: Hiroaki Akamatsu, Wakayama Medical University
A Phase II Study of Pembrolizumab Plus Amurubicin in Patients With Refractory Small-cell Lung Cancer
To explore the overall response rate (ORR) per RECIST 1.1 as assessed by investigators in subjects with refractory small cell lung cancer treated with pembrolizumab (Pembro) plus amurubicin (AMR).
Study Overview
Status
Unknown
Conditions
Intervention / Treatment
Detailed Description
Open, uncontrolled, multi-center, phase II study.
Study Type
Interventional
Enrollment (Anticipated)
25
Phase
- Phase 2
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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-
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Wakayama, Japan, 641-8509
- Wakayama Medical University
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
20 years and older (ADULT, OLDER_ADULT)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Have a histologically or cytologically confirmed diagnosis of SCLC.
- Confirmed radiological relapse within 90 days from the last day of first-line chemotherapy.
- Have adequate tumor tissue sample to test PD-L1 immunohistochemistry.
- Have measurable disease based on RECIST 1.1 as determined by the site.
- Be ≥20 years of age on day of signing informed consent.
- Have a performance status of 0 or 1 on the Eastern Cooperative Oncology Group
- Have adequate organ function as indicated by the following laboratory values
- Is expected to live more than 90 days.
- Be willing and able to provide written informed consent/assent for the trial.
- Female subject of childbearing potential should have a negative urine or serum pregnancy within 72 hours from registration.
- Female subjects of childbearing potential must be willing to use an adequate method of contraception as outlined in Section 5.7.2 - Contraception, for the course of the study through 120 days (or longer as specified by local institutional guidelines) after the last dose of study medication.
- Male subjects of childbearing potential must agree to use an adequate method of contraception as outlined in Section 5.7.2- Contraception, starting with the first dose of study therapy through 120 days (or longer as specified by local institutional guidelines) after the last dose of study therapy.
Exclusion Criteria:
- Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigation device within 30 days from registration.
- Is receiving systemic steroid therapy ≤ 3 days from registration or receiving any other form of immunosuppressive medication.
- Has received prior systemic cytotoxic chemotherapy, biological therapy, OR major surgery within 3 weeks of the first dose of trial treatment; received thoracic radiation therapy of > 30 Gy within 6 months from registration.
- Has received prior therapy with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CD137, or anti-Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) antibody.
- Has symptomatic central nervous system (CNS) metastases and/or carcinomatous meningitis.
- Active autoimmune disease that has required systemic treatment in past 2 years (i.e. with use of disease modifying agents, corticosteroids or immunosuppressive drugs).
- Has had an allogeneic tissue/solid organ transplant.
- History of noninfectious pneumonitis that required steroids or current active pneumonitis, or any evidence of interstitial lung disease by CT scan.
- Has received or will receive a live vaccine within 30 days from registration.
- Has an active infection requiring intravenous systemic therapy and oral administration.
- Has known history of Human Immunodeficiency Virus (HIV) (HIV 1/2 antibodies).
- Has known active Hepatitis B, or Hepatitis C.
- Has any history of prior malignancy, with the exception of basal cell carcinoma of the skin, superficial bladder cancer, squamous cell carcinoma of the skin, in situ cervical cancer, or has undergone potentially curative therapy with no evidence of that disease recurrence for 5 years since initiation of that therapy.
- Has Known history of serious allergy.
- Has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial, interfere with the subject's participation for the full duration of the trial, or is not in the best interest of the subject to participate, in the opinion of the treating investigator.
- Has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial.
- Is pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the trial, starting with the pre-screening or screening visit through 120 days (or longer as specified by local institutional guidelines) after the last dose of trial treatment.
- Hypersensitivity or allergy to pembrolizumab or any of its excipients, and/or to AMR or any of its excipients.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: TREATMENT
- Allocation: NA
- Interventional Model: SINGLE_GROUP
- Masking: NONE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: Pembrolizumab plus amurubicin
Pembrolizumab 200mg/body plus amurubicin 40mg/m2, intravenous, every 3 weeks
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Pembrolizumab 200mg/body plus amurubicin 40mg/m2, intravenous, every 3 weeks
Other Names:
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Overall response rate
Time Frame: Imaging will be performed every 6 weeks through study completion, an average of 6 months
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Overall response rate will be assessed using RECIST ver1.1 by investigators
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Imaging will be performed every 6 weeks through study completion, an average of 6 months
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Principal Investigator: Hiroaki Akamatsu, M.D., Third Department of Internal Medicine, Wakayama Medical University
- Principal Investigator: Nobuyuki Katakami, M.D., Ph.D., Division of Integrated Oncology, Institute of Biomedical Research and Innovation
- Principal Investigator: Kazuhiko Nakagawa, M.D., Ph.D., Department of Medical Oncology, Kinki University, Faculty of Medicine
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (ACTUAL)
August 1, 2017
Primary Completion (ANTICIPATED)
December 28, 2020
Study Completion (ANTICIPATED)
December 31, 2020
Study Registration Dates
First Submitted
August 12, 2017
First Submitted That Met QC Criteria
August 16, 2017
First Posted (ACTUAL)
August 17, 2017
Study Record Updates
Last Update Posted (ACTUAL)
May 19, 2020
Last Update Submitted That Met QC Criteria
May 18, 2020
Last Verified
May 1, 2020
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- MK-3475-IIT-55441
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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