Th17 Inducing Cytokines Pregnancy and After Postpartum

February 22, 2018 updated by: Veli Özgen Öztürk, Aydin Adnan Menderes University

Interleukin-17 and Th17 Inducing Cytokines Exacerbate Periodontal Disease During Pregnancy and Postpartum

The aim of this study was to investigate salivary and gingival crevicular fluid (GCF) levels of IL-17A, IL-17E, IL-6 AND IL-23 during 2/3 trimester of pregnancy and after delivery.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

IL-17 have a synergytic effect with IL-6 and IL-23. IL-17A levels elevated with periodontal diseases. Many systemical chronic conditions such as atherosclerosis and cardiovascular disease, pregnancy may contribute increasing of IL-17 family cytokine.

Study Type

Observational

Enrollment (Actual)

114

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

19 years to 40 years (Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

Female

Sampling Method

Probability Sample

Study Population

All participants had 20 teeth present at least.

Description

Inclusion Criteria:

  • women 2 and 3 trimester of their pregnancy

Exclusion Criteria:

  • any known systemic disease,
  • periodontal treatment within the last six months,
  • patients having less than 10 teeth,
  • smokers,
  • individuals with a BMI > 30 kg/m2,
  • gestational diabetes and preeclampsia during pregnancy.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Pregnancy group
Women, who were in their second trimester (weeks 16-24) or third trimester (weeks 25-34)selected for the study. Saliva and GCF samples were collected and clinical periodontal measurements were made gently
Other: Saliva collection
Other: GCF collection
Postpartum group
Postpartum women 6 months after giving birth recalled. Saliva and GCF samples were collected and clinical periodontal measurements were made.
Other: Saliva collection
Other: GCF collection

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Changing Il-17A levels
Time Frame: 6 month
Salivary and GCF level measured by ELISA
6 month

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Changing IL-6 levels
Time Frame: 6 month
Salivary and GCF level measured by ELISA
6 month
Changing IL-23 levels
Time Frame: 6 month
Salivary and GCF level measured by ELISA
6 month
Changing IL-17E levels
Time Frame: 6 month
Salivary and GCF level measured by ELISA
6 month

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Aydin Adnan Menderes University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 1, 2013

Primary Completion (Actual)

April 1, 2014

Study Completion (Actual)

January 1, 2018

Study Registration Dates

First Submitted

January 26, 2018

First Submitted That Met QC Criteria

February 22, 2018

First Posted (Actual)

February 28, 2018

Study Record Updates

Last Update Posted (Actual)

February 28, 2018

Last Update Submitted That Met QC Criteria

February 22, 2018

Last Verified

February 1, 2018

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • BAP-2015

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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