- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03525145
Platelet Reactivity And Clinical ThrombotIC Events Study (PRACTICE)
January 3, 2019 updated by: Han Yaling, Shenyang Northern Hospital
Platelet function testing has been considered for DAPT strategy adjustments to reduce the patient's risk of ischemia and bleeding.
Although several previous RCT studies did not find any benefit in the detection of platelet function, the previous studies were mostly low-risk populations, and the P2Y12 receptor antagonists were simply clopidogrel, and the detection methods were relatively simple.
Therefore, the need for platelet monitoring in high-risk ACS patients receiving new potent P2Y12 inhibitor ticagrelor, as well as the diagnostic threshold for different platelet function assays needs further study.
In addition, due to the differences on the response to anti-platelet drugs between the East and the West, it is not appropriate to simply refer to the conclusion of the other party.
However, as of now, there is no large sample randomized controlled study systematically focused on the applicability and status of platelet function tests in East Asian populations, especially Chinese populations.
Study Overview
Status
Unknown
Study Type
Observational
Enrollment (Anticipated)
1500
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Liaoning
-
Shenyang, Liaoning, China
- Recruiting
- Northern Hospital
-
Contact:
- Yaling Han, Dr
- Phone Number: +86-24-23922184
- Email: 13998847715@qq.com
-
Principal Investigator:
- Yaling Han, MD
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 80 years (ADULT, OLDER_ADULT)
Accepts Healthy Volunteers
N/A
Genders Eligible for Study
All
Sampling Method
Probability Sample
Study Population
Patients with acute coronary syndrome undergoing antiplatelet therapy
Description
Inclusion Criteria:
- Age 18-80 years old;
- There was a history of at least one acute coronary syndrome (ACS) attack within 14 days before enrollment, including unstable angina, non-ST elevation myocardial infarction, or ST-elevation myocardial infarction;
- Being treated with aspirin and a P2Y12 inhibitor (clopidogrel or ticagrelor);
- Plan to apply dual antiplatelet drugs (DAPT, aspirin + P2Y12 inhibitor) for at least 12 months;
- Voluntary signature of informed consent
Exclusion Criteria:
- In combination with other anti-platelet drugs, such as cilostazol;
- Have received glycoprotein IIb/IIIa inhibitor within 72 hours before enrollment;
- receving a P2Y12 inhibitor loading does less than 72h or maintenance (unloaded) less than 5d;
- Plan to perform any coronary revascularization within 30 days;
- The need for oral anticoagulants (warfarin, factor II or factor X inhibitors);
- Predicted survival time <12 months for patients with known severe progressive disease (such as malignancy) or extreme depletion of the disease;
- pregnant women or pregnant people;
- Any situation that may interfere with the research process, such as dementia, delirium, alcoholism, etc.;
- expected to undergo surgery within 1 year;
- Patients participating in other ongoing clinical studies
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Cardiovascular thrombotic events
Time Frame: One Year
|
Cardiovascular death, non-fatal myocardial infarction, stroke, or stent thrombosis
|
One Year
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Cardiovascular death
Time Frame: One Year
|
Cardiovascular death
|
One Year
|
BARC(Bleeding Academic Research Consortium )2-5 Bleeding
Time Frame: One Year
|
BARC2-5 Bleeding
|
One Year
|
MACCE(Major adverse cardiac and cerebral events)
Time Frame: One Year
|
Cardiovascular death, non-fatal myocardial infarction, stroke, or ischemic-driven target vessel revascularization
|
One Year
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Study Director: Yaling Han, MD, Northern Hospital
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (ACTUAL)
September 1, 2018
Primary Completion (ANTICIPATED)
May 31, 2020
Study Completion (ANTICIPATED)
May 31, 2020
Study Registration Dates
First Submitted
April 25, 2018
First Submitted That Met QC Criteria
May 3, 2018
First Posted (ACTUAL)
May 15, 2018
Study Record Updates
Last Update Posted (ACTUAL)
January 4, 2019
Last Update Submitted That Met QC Criteria
January 3, 2019
Last Verified
January 1, 2019
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- PRACTICEV1.02
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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