The Mechanism and Prognosis of Pulmonary Circulation Dysfunction

July 27, 2018 updated by: Jianguo He, Chinese Academy of Medical Sciences, Fuwai Hospital

The Mechanism and Prognosis of Pulmonary Circulation Dysfunction in Pulmonary Injury and Recovery

Venous thromboembolism (VTE) is a condition which influenced by both environmental and genetic factors. This study is going to explore new significant Single nucleotide polymorphisms (SNPs) associated with VTE by Genome-Wide Association Studies (GWAS) and bioinformatics analysis. Transcriptomics and cytokine antibody array are also used to find new biomarkers of VTE's early diagnosis, severity and prognosis.

Study Overview

Status

Unknown

Conditions

Study Type

Observational

Enrollment (Anticipated)

1000

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • China
    • Beijing
      • Beijing, Beijing, China, 100037
        • Recruiting
        • Cardiovascular Institute and Fu Wai Hospital
        • Contact:
        • Principal Investigator:
          • Jianguo He, MD

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

14 years and older (Child, Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

Acute VTE patients and healthy controls

Description

Inclusion Criteria:

  • Chinese Han population older than 14 years old
  • Acute VTE patients diagnosed in 1 month
  • With informed consent

Exclusion Criteria:

  • Patients with psychosis
  • Patients with contraindications for computed tomographic pulmonary angiography (CTPA)
  • Chronic VTE
  • Recurrence of chronic VTE

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
All cause death
Time Frame: 6 months
death
6 months

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Venous thromboembolism (VTE) recurrence
Time Frame: 6months
VTE recurrence detected by echocardiography or CTPA scan
6months
chronic thromboembolism pulmonary hypertension(CTEPH)
Time Frame: 6 months
newly developed CTEPH detected by pulmonary angiography
6 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Chinese Academy of Medical Sciences, Fuwai Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Anticipated)

August 10, 2018

Primary Completion (Anticipated)

December 31, 2020

Study Completion (Anticipated)

December 31, 2020

Study Registration Dates

First Submitted

January 4, 2018

First Submitted That Met QC Criteria

July 27, 2018

First Posted (Actual)

August 6, 2018

Study Record Updates

Last Update Posted (Actual)

August 6, 2018

Last Update Submitted That Met QC Criteria

July 27, 2018

Last Verified

July 1, 2018

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 2017-I2M-1-009

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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