PECO Air Purification in Hospital Rooms to Improve Health Outcomes for Pediatric Respiratory Distress

Use of PECO Air Purification in Hospital Rooms to Improve Health Outcomes for Pediatric Respiratory Distress

This study will investigate the efficacy of a novel air purification technology, Photo Electrochemical Oxidation (PECO), has on pediatric patients hospitalized for respiratory distress. The study will take place at Mercyhealth Hospital - Rockton Avenue where all 23 pediatric rooms will be outfitted with portable PECO air purifying units. The main outcomes are the length of stay and progression to ICU, which will be compared with historical controls.

Study Overview

• Status: Completed
• Conditions: Pneumonia; Asthma; Respiratory Distress Syndrome
• Intervention / Treatment: Device: Photo Electrochemical Oxidation (PECO) for Air Purification

Detailed Description

The goal of this study is to assess whether using PECO to purify air in a hospital can improve health outcomes for pediatric patients with respiratory distress.

The results of this study will be used in three primary ways:

1. As evidence to support an installation of PECO in hospital HVAC systems to improve the standard of care for patients with respiratory distress
2. Towards dissemination efforts through publication in a peer-reviewed journal and presentation at national and international conferences
3. For informing healthcare providers and stakeholders

There are no plans to repeat this study with other hospital partners

• Study Type: Interventional
• Enrollment (Actual): 274
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Illinois
    • Rockford, Illinois, United States, 61103
      • Mercyhealth Hospital - Rockton Avenue

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 1 year to 17 years (CHILD)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria: All pediatric patients who are admitted to the Mercyhealth Hospital - Rockton Avenue following the Start Date and have infectious or non-infectious respiratory distress as defined by the following ICD codes will be included in the study:

• J00-J06: Acute upper respiratory infections
• J09-J18: Influenza and pneumonia
• J20-J22: Other acute lower respiratory infections
• J30-J39: Other diseases of upper respiratory tract
• J40-J47: Chronic lower respiratory diseases
• J60-J70: Lung diseases due to external agents
• J80-J84: Other respiratory diseases principally affecting the interstitium
• J85-J86: Suppurative and necrotic conditions of the lower respiratory tract
• J90-J94: Other diseases of the pleura
• J95-J95: Intraoperative and postprocedural complications and disorders of respiratory system, not elsewhere classified

Exclusion Criteria:

• Any patient admitted to the NICU
• Patients in the ER only
• Any patient with non-respiratory conditions
• Adults

Study Plan

How is the study designed?

Design Details

• Primary Purpose: PREVENTION
• Allocation: NA
• Interventional Model: SINGLE_GROUP
• Masking: NONE

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
EXPERIMENTAL: PECO; All pediatric patients admitted for respiratory distress will have the intervention of Photo Electrochemical Oxidation (PECO) for Air Purification.	Device: Photo Electrochemical Oxidation (PECO) for Air Purification; PECO air purifiers from Molekule will be placed in every patient room. Health metrics will be tracked for patients whose diagnosis is respiratory distress.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Length of stay	Total length of hospital stay for patient	5 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Readmission rate	Rate of readmission within 30 days of discharge	1 months

Collaborators and Investigators

• Sponsor: Molekule
• Collaborators: Mercy Health System
• Investigators: Principal Investigator: Nikhil Rao, Molekule

Study record dates

Study Major Dates

• Study Start (ACTUAL): August 8, 2018
• Primary Completion (ACTUAL): December 31, 2018
• Study Completion (ACTUAL): December 31, 2018

Study Registration Dates

• First Submitted: August 20, 2018
• First Submitted That Met QC Criteria: August 23, 2018
• First Posted (ACTUAL): August 27, 2018

Study Record Updates

• Last Update Posted (ACTUAL): May 17, 2019
• Last Update Submitted That Met QC Criteria: May 15, 2019
• Last Verified: May 1, 2019

More Information

Terms related to this study

• Keywords: asthma; respiratory distress; pneumonia; bronchiolitis; environmental intervention; pediatric hospitalization
• Additional Relevant MeSH Terms: Infections; Respiratory Tract Infections; Respiratory Tract Diseases; Respiration Disorders; Lung Diseases; Infant, Newborn, Diseases; Infant, Premature, Diseases; Pneumonia; Respiratory Distress Syndrome; Respiratory Distress Syndrome, Newborn
• Other Study ID Numbers: Molekule-08082018

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No