Correlation Between Plasma Oxidized Low Density Lipoprotein Levels And Postoperative Delirium

Postoperative delirium (POD) refers to an acute neurocognitive disorder that occurs within 1 week after surgery or before discharge. Old age is one of the important risk factors for postoperative delirium. The incidence rate of the elderly is high, and the life span of human beings is increasing. Postoperative delirium has adverse effects on both short-term and long-term outcomes, including mortality, ability to work, and dependence on society.

Low-density lipoprotein (LDL) is a key molecule in the cholesterol transport mechanism and is easily oxidized to oxidized low-density lipoprotein (OxLDL). Oxidized low density lipoproteins are immunogenic and are also cytotoxic to endothelial cells. Some studies have shown that increased oxidative stress is one of the earliest changes in disease, and similar signs can be detected in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI), such as protein oxidation and lipids. An increase in the quality of the peroxidation index. For the study of anesthesiology, oxidative stress theory has long been recognized as one of the mechanisms of postoperative delirium. We have a hypothesis that plasma oxidized low-density lipoprotein levels are associated with postoperative delirium and can be used as an early warning marker for disease occurrence.

Based on clinical research data, we conducted a prospective cohort study to explore the correlation between plasma oxidized low-density lipoprotein levels and postoperative sputum, providing clinical prediction and diagnostic value.

Study Overview

• Status: Unknown
• Conditions: Postoperative Delirium
• Intervention / Treatment: Other: plasma oxidized low-density lipoprotein levels

• Study Type: Observational
• Enrollment (Anticipated): 300

Contacts and Locations

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 65 years to 90 years (OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Patients in orthopedics, urology and general surgery .

Description

Inclusion Criteria:

• Surgical treatment was performed in our hospital under standard anesthesia.
• Patients in orthopedics, urology and general surgery.

Exclusion Criteria:

• Patients with mental illness or taking psychotropic substances before surgery.
• Preoperative dementia or cognitive dysfunction.
• Unable to communicate and cooperate with patients due to coma, language barrier or end-stage disease before surgery.
• ASA greater or equal to 4.
• Patients who have undergone neurosurgery and cardiac vascular surgery.

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Case group; Patients with postoperative delirium.	Other: plasma oxidized low-density lipoprotein levels; Detection of plasma oxidized low-density lipoprotein levels
Control group; Patients who have not had postoperative delirium.	Other: plasma oxidized low-density lipoprotein levels; Detection of plasma oxidized low-density lipoprotein levels

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
plasma oxidized low-density lipoprotein levels	Preoperative plasma oxidized low-density lipoprotein levels	through study completion, an average of 4 months
plasma oxidized low-density lipoprotein levels	Postoperative plasma oxidized low-density lipoprotein levels	through study completion, an average of 4 months

Collaborators and Investigators

• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Study record dates

Study Major Dates

• Study Start (ANTICIPATED): May 20, 2019
• Primary Completion (ANTICIPATED): September 20, 2019
• Study Completion (ANTICIPATED): September 20, 2019

Study Registration Dates

• First Submitted: May 19, 2019
• First Submitted That Met QC Criteria: May 28, 2019
• First Posted (ACTUAL): May 30, 2019

Study Record Updates

• Last Update Posted (ACTUAL): May 30, 2019
• Last Update Submitted That Met QC Criteria: May 28, 2019
• Last Verified: May 1, 2019

More Information

Terms related to this study

• Keywords: Postoperative Delirium
• Additional Relevant MeSH Terms: Mental Disorders; Nervous System Diseases; Neurologic Manifestations; Confusion; Neurobehavioral Manifestations; Neurocognitive Disorders; Delirium
• Other Study ID Numbers: 2019-092

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No