Correlation Between Plasma Oxidized Low Density Lipoprotein Levels And Postoperative Delirium

May 28, 2019 updated by: Second Affiliated Hospital, School of Medicine, Zhejiang University

Postoperative delirium (POD) refers to an acute neurocognitive disorder that occurs within 1 week after surgery or before discharge. Old age is one of the important risk factors for postoperative delirium. The incidence rate of the elderly is high, and the life span of human beings is increasing. Postoperative delirium has adverse effects on both short-term and long-term outcomes, including mortality, ability to work, and dependence on society.

Low-density lipoprotein (LDL) is a key molecule in the cholesterol transport mechanism and is easily oxidized to oxidized low-density lipoprotein (OxLDL). Oxidized low density lipoproteins are immunogenic and are also cytotoxic to endothelial cells. Some studies have shown that increased oxidative stress is one of the earliest changes in disease, and similar signs can be detected in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI), such as protein oxidation and lipids. An increase in the quality of the peroxidation index. For the study of anesthesiology, oxidative stress theory has long been recognized as one of the mechanisms of postoperative delirium. We have a hypothesis that plasma oxidized low-density lipoprotein levels are associated with postoperative delirium and can be used as an early warning marker for disease occurrence.

Based on clinical research data, we conducted a prospective cohort study to explore the correlation between plasma oxidized low-density lipoprotein levels and postoperative sputum, providing clinical prediction and diagnostic value.

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Anticipated)

300

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

65 years to 90 years (OLDER_ADULT)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Patients in orthopedics, urology and general surgery .

Description

Inclusion Criteria:

  • Surgical treatment was performed in our hospital under standard anesthesia.
  • Patients in orthopedics, urology and general surgery.

Exclusion Criteria:

  • Patients with mental illness or taking psychotropic substances before surgery.
  • Preoperative dementia or cognitive dysfunction.
  • Unable to communicate and cooperate with patients due to coma, language barrier or end-stage disease before surgery.
  • ASA greater or equal to 4.
  • Patients who have undergone neurosurgery and cardiac vascular surgery.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Case group
Patients with postoperative delirium.
Other: plasma oxidized low-density lipoprotein levels
Detection of plasma oxidized low-density lipoprotein levels
Control group
Patients who have not had postoperative delirium.
Other: plasma oxidized low-density lipoprotein levels
Detection of plasma oxidized low-density lipoprotein levels

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
plasma oxidized low-density lipoprotein levels
Time Frame: through study completion, an average of 4 months
Preoperative plasma oxidized low-density lipoprotein levels
through study completion, an average of 4 months
plasma oxidized low-density lipoprotein levels
Time Frame: through study completion, an average of 4 months
Postoperative plasma oxidized low-density lipoprotein levels
through study completion, an average of 4 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Second Affiliated Hospital, School of Medicine, Zhejiang University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (ANTICIPATED)

May 20, 2019

Primary Completion (ANTICIPATED)

September 20, 2019

Study Completion (ANTICIPATED)

September 20, 2019

Study Registration Dates

First Submitted

May 19, 2019

First Submitted That Met QC Criteria

May 28, 2019

First Posted (ACTUAL)

May 30, 2019

Study Record Updates

Last Update Posted (ACTUAL)

May 30, 2019

Last Update Submitted That Met QC Criteria

May 28, 2019

Last Verified

May 1, 2019

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2019-092

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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