- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04123756
Predicting Outcome Following Standardized Exercise Therapy in Knee Osteoarthritis Patients
Smerteprofiler Som Redskab Til at prædiktere Effekten af 6-8 Ugers GLA:D®-forløb Hos Patienter Med Smertefuld Slidgigt i knæene
Pain sensitization has been associated with pain severity in people with knee osteoarthritis (KOA) and a neuropathic pain component has been identified in up to 30% of KOA patients. Mechanistic pain profiling aims to identify the underlying mechanisms in the peripheral and central nervous systems, which are associated to the clinical pain.
In addition, the mechanisms underlying the pain relieving effect of standardized exercise therapy are largely unknown, but it is hypothesized that they are linked to the patient's ability to activate the descending pain inhibitory pathways (conditioned pain modulation, CPM) in the central nervous system. Mechanistic pain profiling including CPM have been used prognostic to identify responders to treatment, but these measures as a prognostic tool for standardized exercise therapy has not been investigated.
The primary aim of this study is to investigate if mechanistic pain profiling alone or in combination with clinical pain measures before standardized exercise therapy can predict the patients' pain reduction following the exercise therapy program
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
-
-
Aarhus, Denmark, 8000
- FysioDanmark Aarhus
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- The American College of Rheumatology for clinical knee osteoarthritis (excluding radiological OA assessment)
Exclusion Criteria:
- Known factors to influence pain and pain sensitization
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
pain reduction
Time Frame: 1-2 weeks after last exercise session
|
Pain measured on a numerical rating scale from 0 (no pain) to 10 (worst pain imaginable)
|
1-2 weeks after last exercise session
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Estimated)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- N-20190045
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Knee Osteoarthritis
-
LifeBridge HealthMicroPort Orthopedics Inc.; Rubin Institute for Advanced OrthopedicsRecruitingKnee Osteoarthritis | Osteoarthritis, Knee | Knee Pain Chronic | Arthropathy of Knee Joint | Knee Disease | Osteoarthritis Knees Both | Osteoarthritis Knee Left | Osteoarthritis Knee RightUnited States
-
University Hospital, Clermont-FerrandSanofiCompletedKnee Osteoarthritis (Knee OA)France
-
Jiangsu XinChen-Techfields Pharma Co., LTD.Completed
-
Novartis PharmaceuticalsRecruitingSymptomatic Knee OsteoarthritisUnited States, Spain, Hungary, Argentina, Germany, Slovakia, Czechia, Belgium, Romania
-
University of BathUniversity of Oxford; 3D Metal Printing Ltd; Versus ArthritisRecruitingMedial Knee OsteoarthritisUnited Kingdom
-
Max Biocare Pty. Ltd.Completed
-
University of IowaThe American Geriatrics SocietyCompletedKnee Osteoarthritis | Symptomatic Knee OsteoarthritisUnited States
-
Laval UniversityFonds de la Recherche en Santé du Québec; Natural Sciences and Engineering... and other collaboratorsCompleted
-
Chonbuk National University HospitalCompletedMild Knee OsteoarthritisKorea, Republic of
Clinical Trials on standardized exercise therapy for knee OA patients
-
Frederiksberg University HospitalCompleted
-
US Department of Veterans AffairsCompleted
-
Pacira Pharmaceuticals, IncRecruiting
-
University of ZurichLund University; Kantonsspital Aarau; Maastricht University; Kantonsspital OltenCompleted
-
University of PittsburghCompleted
-
University of PittsburghNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)Completed
-
King Saud UniversityUnknown
-
Shinshu UniversityRecruitingOsteoarthritis of Multiple Joints | Progression of Rheumatoid ArthritisJapan
-
Shirley Ryan AbilityLabNorthwestern UniversityRecruitingArthritis | Joint Diseases | Musculoskeletal Diseases | Rheumatic Diseases | Osteoarthritis | Knee OsteoarthritisUnited States
-
Foundation University IslamabadActive, not recruiting