Evaluating the Prevalence and Implications of Obstructive Sleep Apnea Among Somali-Americans: A Translational Research Study

Obstructive Sleep Apnea Among Somali-Americans

Sponsors

Lead sponsor: Mayo Clinic

Source Mayo Clinic
Brief Summary

The investigators seek to advance the understanding of obstructive sleep apnea as it relates to different ethnic origins as well as sex differences. The investigators will compare Somali patients with known obstructive sleep apnea (OSA) to individuals without OSA, and to individuals of other ethnic/racial origins to determine the risk factors (genetic and/or physiologic) associated with developing cardiovascular diseases. This will help the investigators to understand the unique sleep pathology of individuals of African descent.

Detailed Description

Participants can be healthy volunteers or volunteers diagnosed with obstructive sleep apnea. All patients may undergo a sleep study (i.e. hospital or home-based), physical examination, questionnaires, blood and urine samples, ultrasound scan of the heart and brachial artery in the arm, CT scan, DEXA scan, paced breathing test, cardiopulmonary test and chemo-sensitivity test.

Overall Status Recruiting
Start Date October 25, 2019
Completion Date December 31, 2028
Primary Completion Date December 31, 2028
Study Type Observational
Primary Outcome
Measure Time Frame
To assess the prevalence of obstructive sleep apnea 10 years
To determine the severity of obstructive sleep apnea 10 years
Secondary Outcome
Measure Time Frame
24 hour mean arterial pressure 10 years
Vascular endothelial function 10 years
Insulin sensitivity 10 years
Body composition 10 years
Enrollment 100
Condition
Eligibility

Sampling method: Non-Probability Sample

Criteria:

Inclusion Criteria:

- Self-identify as Somali, African, Asian, and European descent.

- Adult males and females who are older than 18 years of age.

Exclusion Criteria:

- Minors under 18 years or adults over 100 years

- Positive pregnancy

Gender: All

Minimum age: 18 Years

Maximum age: N/A

Healthy volunteers: Accepts Healthy Volunteers

Overall Official
Last Name Role Affiliation
Virend Somers, MD Principal Investigator Mayo Clinic
Overall Contact

Last name: Essa Mohamed, PhD

Phone: 507-255-4169

Email: [email protected]

Location
facility status contact contact_backup investigator Mayo Clinic Essa Mohamed, PhD 507-255-4169 [email protected] Virend Somers, MD, PhD Principal Investigator Essa A. Mohamed, PhD Sub-Investigator Erik K. St Louis, MD Sub-Investigator Meghna P. Mansukhani, MD Sub-Investigator C. Anwar A. Chahal, MBChB, PhD Sub-Investigator Nasra H. Giama, DNP, RN Sub-Investigator Joyce E. Balls-Berry, PhD Sub-Investigator Fowsiyo Ahmed, MBBS Sub-Investigator
Location Countries

United States

Verification Date

December 2019

Responsible Party

Responsible party type: Principal Investigator

Investigator affiliation: Mayo Clinic

Investigator full name: Virend Somers

Investigator title: Principal Investigator

Keywords
Has Expanded Access No
Condition Browse
Arm Group

Arm group label: Somali Descent

Description: Study participants who are of Somali origin.

Arm group label: Non-Somali Descent

Description: Study participants who are not of Somali origin.

Acronym Somali OSA
Patient Data No
Study Design Info

Observational model: Cohort

Time perspective: Prospective

Source: ClinicalTrials.gov