- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04193462
Relationship-Based Intervention for Post-Partum Depression
A Brief Relationship-Based Intervention for Post-Partum Depression; Effects on Mother's Hormones, Depression and Parenting and on Infant Social-Emotional Development
Study Overview
Status
Conditions
Detailed Description
Subjects: 60 Mothers will be interviewed and diagnosed as suffering from Post-Partum- depression (PPD) according to the Diagnostic and Statistical Manual of Mental Disorders, IV version (DSM-IV), enrolling within 3-8 months postpartum. Mothers will be recruited through social media networks. Additional 40 mothers, 3-8 months postpartum will be assessed and diagnosed as not suffering from PPD or any other psychiatric psychopathology.
Procedure: The baseline assessment will be conducted at the infant's home. A parent-infant interaction will be videotaped and salivary oxytocin samples will be collected from the infant and from the mother.
The women in the PPD group will participate in 8 weeks of dyadic psychotherapy (DP) combining video feedback, or a psycho-educational treatment regarding child development (randomize selection will be made). During the 8-week treatment, salivary oxytocin samples will be collected from the infants and from the mother at the beginning and the end of each session.
Another assessment will be conducted at the infant's home, at the end of the treatment. As in the baseline condition, this assessment will include videotaped parent-infant interaction, as well as salivary oxytocin samples collection from the mother and from the infant. Parent-infant interaction will be filmed and assessed using the CIB Manual (Feldman, 1998) and the synchrony coding system.
Healthy mothers will undergo the same baseline assessment and a second assessment within 2-3 months, and won't get any treatment.
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Moran Influs, Phd
- Phone Number: 972-545343400
- Email: moran.influs@gmail.com
Study Contact Backup
- Name: Ruth Feldman, Phd
- Phone Number: 972-544566353
- Email: feldman.ruth@gmail.com
Study Locations
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Herzliya, Israel, 4610101
- Recruiting
- Interdisciplinary Center
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Contact:
- Moran Influs, Phd
- Phone Number: 972-5343400
- Email: moran.influs@gmail.com
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Principal Investigator:
- Moran Influs, Phd
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- women diagnosed with Post-Partum depression, major or minor, according to the Diagnostic and Statistical Manual of Mental Disorders, 5th version (DSM-5)
- 3-8 months after birth of one baby
Exclusion Criteria:
- Mothers of twins
- Mothers of premature babies
- Comorbidity of psychopathology, women who have severe personality disorder or other psychiatric diagnose, besides depression or anxiety
- Women or babies who suffer from severe medical condition, such as developmental problems for the baby or disability.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Post-partum depression- Dyadic psychotherapy
Mothers and infants will be treated with 8 weeks dyadic psychotherapy at their home using video-feedback of mother-infant interaction to discuss main issues in the mother-infant relationship.
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Mothers and infants will be treated with dyadic psychotherapy focused on interactions, emphasizing eye contact, body language, empathy, and social reciprocity.
Dyadic psychotherapy will be administered one time a week during the 8-week trial period, at the subject's home.
Each session, approximately 90 minutes long, will include videotaping mother-infant interaction, watching the last session's interaction as a part of video-feedback technique, and discussing main issues in the mother-infant relationship.
In addition, each session will begin and end with a- 5-minute episode of affectionate touch and gaze synchrony between the mother and her infant.
During the whole therapy-trial, the therapist will also use cognitive-behavioral approach to address the mother's perception of her infant and of herself as a mother.
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Active Comparator: Post-partum depression- Psycho-educational therapy
8 weeks of supportive therapy for the mother at her house, involving the baby.
Each session will include different aspects of psycho-education regarding development of the baby.
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Mothers will receive a therapy in their homes for 8 weeks, 1.5 hours for each session by a therapist arriving at their home.
Each session will address a different developmental aspects of the baby (feeding, movement, social-emotional development etc.).
Therapist will ask the mother about her baby, will give information about developmental needs and expectations and will help mother to enrich child's development and deal will potential problems
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No Intervention: Control- Healthy mothers and their babies
No intervention for 8 weeks.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Behavioral Assessment of dialogue
Time Frame: trail 1-baseline
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Interactions will be coded with the "Coding Interactive Behavior" (CIB) manual (Feldman, 1998), infant version.
This version is composed of 37 codes rated on a scale of 1 to 5, as higher score means a better outcome.
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trail 1-baseline
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Hormonal Assays- Oxytocin
Time Frame: trail 1-baseline
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Three saliva samples will be collected using Salivettes® at baseline, following interaction, and 20 minutes after end and averaged.
All samples will be then stored at -20°C.
Salivette will be treated as following: centrifuged twice, at 4°C at 1500 x g for 30 minutes, aliquoted and lyophilized over few days- to concentrate by 4 times.
The dry samples will be reconstructed in the assay buffer immediately before analysis using an oxytocin enzyme immunoassay commercial kit (ENZO, NY).
The assay preformed according the kit's instruction.
The concentration of oxytocin will be calculated using MatLab-7
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trail 1-baseline
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Behavioral Assessment of dialogue
Time Frame: trail 2- after treatment- 2-3 months after trail 1
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Interactions will be coded with the "Coding Interactive Behavior" (CIB) manual (Feldman, 1998), infant version.
This version is composed of 37 codes rated on a scale of 1 to 5, as higher score means a better outcome.
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trail 2- after treatment- 2-3 months after trail 1
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Hormonal Assays- Oxytocin
Time Frame: trail 2- after treatment- 2-3 months after trail 1
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Three saliva samples will be collected using Salivettes® at baseline, following interaction, and 20 minutes after end and averaged.
All samples will be then stored at -20°C.
Salivette will be treated as following: centrifuged twice, at 4°C at 1500 x g for 30 minutes, aliquoted and lyophilized over few days- to concentrate by 4 times.
The dry samples will be reconstructed in the assay buffer immediately before analysis using an oxytocin enzyme immunoassay commercial kit (ENZO, NY).
The assay preformed according the kit's instruction.
The concentration of oxytocin will be calculated using MatLab-7
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trail 2- after treatment- 2-3 months after trail 1
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Collaborators and Investigators
Investigators
- Study Director: Moran Influs, Phd, Interdisciplinary Center Herzliya, Israel
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- InterdisciplinaryCH
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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