Influencing Factors of Cerebrovascular Disease and Cognition in Hemodialysis Patients

Influencing Factors of Cerebrovascular Disease and Cognition in Hemodialysis Patients: an Observational Study

In this observational study, the investigators evaluate the influencing factors of cerebrovascular disease and cognition in hemodialysis patients.

Study Overview

• Status: Recruiting
• Conditions: Cerebrovascular Disorders; Cognitive Impairment; Hemodialysis

• Study Type: Observational
• Enrollment (Estimated): 20

Contacts and Locations

• Study Contact: Name: Jing Chen; Phone Number: 862152889325; Email: chenjing1998@fudan.edu.cn

Study Locations

• China
  • Shanghai
    • Shanghai, Shanghai, China, 200040
      • Recruiting
      • Huashan Hospital
      • Contact: Qian Zhang

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 50 years to 85 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

maintenance hemodialysis patients

Description

Inclusion Criteria:

1. maintenance hemodialysis patients who are younger than 85 years old and older than 50 years old, regardless of gender
2. dialysis vintage is greater than 3 months;

Exclusion Criteria:

1. Those with severe infection and anemia (Hb <60g / L);
2. Those with severe mental illness, metabolic diseases and immune system diseases;
3. Patients with abnormal liver function

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
cerebrovascular disease	Magnetic resonance images will be used to determine the severity of white matter hyperintensity, using the Scheltens scale. Score 2 or more is abnormal.	5 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
changes in cognitive function	The Mini-Mental State Examination (MMSE) will be used to assess the changes in cognitive function.The MMSE has a maximum score of 30 points. The scores are generally grouped as follows: 25-30 points: normal cognition 21-24 points: mild dementia 10-20 points: moderate dementia 9 points or lower: severe dementiaThe Mini-Mental State Examination (MMSE) will be used to assess the changes in cognitive function.The MMSE has a maximum score of 30 points. The scores are generally grouped as follows: 25-30 points: normal cognition 21-24 points: mild dementia 10-20 points: moderate dementia 9 points or lower: severe dementia	5 years

Collaborators and Investigators

• Sponsor: Huashan Hospital
• Investigators: Principal Investigator: Jing Chen, Huashan Hospital

Study record dates

Study Major Dates

• Study Start (Actual): June 1, 2020
• Primary Completion (Estimated): May 31, 2025
• Study Completion (Estimated): May 31, 2025

Study Registration Dates

• First Submitted: May 19, 2020
• First Submitted That Met QC Criteria: June 12, 2020
• First Posted (Actual): June 16, 2020

Study Record Updates

• Last Update Posted (Estimated): February 28, 2024
• Last Update Submitted That Met QC Criteria: February 25, 2024
• Last Verified: February 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Cardiovascular Diseases; Vascular Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Cerebrovascular Disorders
• Other Study ID Numbers: KY2019-465

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No