Effects of a 12-week Combined Exercise Program on Ghrelins in Obese Adolescent Girls

Effects of a 12-week Combined Exercise Program on Acylated and Desacyl Ghrelin, and Ghrelin O Acyl Transferase in Obese Adolescent Girls

This study aimed to explore the effects of a 12-week combined exercise on ghrelin O acyl transferase, acylated ghrelin and desacylated ghrelin levels in obese girls.

Study Overview

• Status: Completed
• Conditions: Ghrelin
• Intervention / Treatment: Other: Combined exercise program; Other: Control

Detailed Description

Little is known about on ghrelin O acyl transferase (GOAT), acylated ghrelin (AG) and desacylated ghrelin (DAG) levels during long-term exercise in adolescent population. Our previous study showed that combined exercise program in overweight children increases DAG with unchanged AG. This study aimed to explore the effects of a 12-week combined exercise on GOAT, AG, and DAG in obese girls.

• Study Type: Interventional
• Enrollment (Actual): 30
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Korea, Republic of
  • Gyeungsangnam-do
    • Yangsan, Gyeungsangnam-do, Korea, Republic of, 50612
      • Pusan National University Yangsan Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 16 years to 18 years (Child, Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Female

Description

Inclusion Criteria:

• girls between 16 and 18 years
• being classified as being overweight or obese defined with the 85th percentile of body mass index or above based on the 2007 growth chart for Korean children aged 2-18 years.
• After consultation with a physician, they were required to be considered physically healthy enough to engage in regular exercise after school.

Exclusion Criteria:

• participation in any weight-management programme in the past 6 months
• engagement in other exercise programs except for regular physical education at school
• smoking
• amenorrhea for consecutive 2 months or more
• being treated for hereditary diseases, mental disorder, hypertension, diabetes mellitus, or musculoskeletal impairments
• taking any medication or supplements for weight control

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Exercise group; Exercise group who performed a combined exercise and 300 kcal/day deficit diet during 12 weeks.	Other: Combined exercise program; Combined exercise programme, consisting of warm-up, aerobic exercise, resistance training, and cool-down, 3 days a week after school for 50 minutes from 17;30 under supervision by a trainer plus 300 kcal deficit diet
Placebo Comparator: Control group; Control group who performed 300 kcal/day deficit diet during 12 weeks.	Other: Control; 300 kcal deficit diet only

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
body fat percent	Changes in body fat percent during 12 weeks	Change from baseline body fat percent at 12 weeks
acylated ghrelin	Changes in concentrations of acylated ghrelin during 12 weeks	Change from concentrations of baseline acylated ghrelin at 12 weeks
desacylated ghrelin	Changes in concentrations of desacylated ghrelin during 12 weeks	Change from concentrations of baseline desacylated ghrelin at 12 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
ghrelin O acyl transferase	Changes in concentrations of ghrelin O acyl transferase during 12 weeks	Change from baseline concentrations of ghrelin O acyl transferase at 12 weeks

Collaborators and Investigators

• Sponsor: Pusan National University Yangsan Hospital

Study record dates

Study Major Dates

• Study Start (Actual): September 10, 2015
• Primary Completion (Actual): December 30, 2015
• Study Completion (Actual): December 31, 2015

Study Registration Dates

• First Submitted: June 22, 2020
• First Submitted That Met QC Criteria: June 22, 2020
• First Posted (Actual): June 25, 2020

Study Record Updates

• Last Update Posted (Actual): June 26, 2020
• Last Update Submitted That Met QC Criteria: June 24, 2020
• Last Verified: June 1, 2020

More Information

Terms related to this study

• Other Study ID Numbers: 04-2015-015

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No