Vaccination Coverage Amongst Children/Young People Attending the PED

Do Children and Young People Attending the Paediatric Emergency Department Have Lower Levels of Vaccination Coverage Than Their Peers in the Local General Population?

In the United Kingdom (UK), most childhood vaccinations are given in the community, although uptake has decreased in recent years. A Paediatric Emergency Department (PED) attendance offers an opportunity to check the vaccination status of children and young people (CYP) and all parents/carers should be asked about this routinely. Those not up-to-date with vaccinations could then be signposted to existing services or perhaps offered a vaccine in the PED.

CYP attending the PED may also have lower vaccination coverage than their peers, so may benefit even more from interventions to increase uptake. However, recall by parents/carers is not always sufficiently accurate to identify those who have not yet received all their age-appropriate vaccinations. The most complete record of an individual's vaccination history is held within their primary care records. However, these records are often in a separate computer system that is inaccessible from the hospital's main computer system, although some information (including vaccination) may be accessed from within the hospital via a third system.

This study aims to see if CYP attending the PED are under-vaccinated compared to their peers and assess the accuracy of parent/carer recall. The results of this study will then be used to inform recommendations for developing better ways to access accurate vaccination data during a PED consultation. If such a system existed, under-vaccinated children could be identified routinely during an attendance, and an intervention offered if appropriate. This would be particularly useful if there was an outbreak of a vaccine-preventable disease such measles.

All CYP (< 16 years old) attending a PED in a district general hospital in Manchester will be invited to participate. CYP/their parent/carer will be asked to provide consent for their vaccination records to be accessed as well as being asked if the child/young person is up-to-date with all their vaccinations. Approximately 1000 participants will be enrolled.

Study Overview

• Status: Completed
• Conditions: Vaccination/Immunisation Status
• Intervention / Treatment: Other: No intervention

• Study Type: Observational
• Enrollment (Actual): 2693

Contacts and Locations

Study Locations

• United Kingdom
  • Greater Manchester
    • Manchester, Greater Manchester, United Kingdom, M8 5RB
      • Paediatric Emergency Department, North Manchester General Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 1 second to 16 years (Child)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Children and young people accessing PED

Description

Inclusion Criteria:

• attending the study site PED; under the age of 16 at the time of attendance; able to give consent or accompanied by someone able to give consent

Exclusion Criteria:

• life threatening illness or injury

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Attendees at Paediatric Emergency Department 1 (PED1); These participants will be recruited from the children and young people (under the age of 16) attending the PED of a large district general hospital. There was going to be a second group recruited but COVID meant that the site was not able to support non-COVID studies by the time the necessary approvals were in place.	Other: No intervention; Observational study

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Percentage of children/young people attending the PED who have received all of their age-appropriate vaccinations.	The % of children and young people attending the PED who have received all of their age-appropriate vaccinations will be compared to their peers in the local general population.	Through study completion (estimated one year)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Accuracy of parent/carer recall of the vaccination status of children/young people attending the PED.	The accuracy of parent/carer recall of the vaccination status of children/young people attending the PED will be made by comparing their responses to electronic community records.	Through study completion (estimated one year)
Percentage of children attending the PED who have received two doses of MMR by the age of 5 years.	The % of children attending the PED who have received two doses of the Measles, Mumps, and Rubella vaccine (MMR) by the age of 5 years will be compared to their peers in the local general population.	Through study completion (estimated one year)
Percentage of children attending the PED who have received at least one dose of MMR by the age of 2 years.	The % of children attending the PED who have received at least one dose of MMR by the age of 2 years will be compared to their peers in the local general population.	Through study completion (estimated one year)

Collaborators and Investigators

• Sponsor: Lancaster University
• Collaborators: Pennine Acute Hospitals NHS Trust

Study record dates

Study Major Dates

• Study Start (Actual): January 24, 2021
• Primary Completion (Actual): November 30, 2021
• Study Completion (Actual): November 30, 2021

Study Registration Dates

• First Submitted: July 15, 2020
• First Submitted That Met QC Criteria: July 23, 2020
• First Posted (Actual): July 24, 2020

Study Record Updates

• Last Update Posted (Actual): December 30, 2021
• Last Update Submitted That Met QC Criteria: December 10, 2021
• Last Verified: December 1, 2021

More Information

Terms related to this study

• Keywords: Child; Vaccination; Immunisation; Paediatric Emergency Department; Opportunistic; Young person
• Other Study ID Numbers: IRAS278815

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES

IPD Sharing Time Frame

Results of study intended to be published in an open access journal within a year of completion of analysis of data.

Anonymised data will be shared under certain circumstances; no patient-identifiable data will be available to other researchers.

• IPD Sharing Access Criteria: Anonymised data will be made available following reasonable request.
• IPD Sharing Supporting Information Type: CSR

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No