VDR SNPs & 25OHD Correlated With Dyslipidemia

The project was aimed to explore the associations of single nucleotide polymorphisms (SNPs) of vitamin D receptor gene with specific circulating lipids in adult Chinese. The circulating 25-hydroxyvitamin D concentration was also tested to explore its interactions with SNPs in the associations.

Study Overview

• Status: Completed
• Conditions: Dyslipidemias; Single Nucleotide Polymorphism
• Intervention / Treatment: Other: No intervention.

• Study Type: Observational
• Enrollment (Actual): 1987

Contacts and Locations

Study Locations

• China
  • Guangdong
    • Shenzhen, Guangdong, China, 518020
      • Shenzhen Center for Chronic Disease Control

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 81 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Adult volunteers visiting a health examination center in Shenzhen city of Guangdong province, China were recruited.

A total of 1,987 adults were included in the analysis, aged from 20 to 81 years old. Among them, there were 1,124 females aged 39 (31 - 49) years old and 863 males aged 36 (30 - 44) years old.

Description

Inclusion Criteria:

• 1) ≥ 20 years old Han Chinese;
• 2) living in Shenzhen for > 2 years;
• 3) free of liver diseases, renal diseases, and any cancers in the past 6 months; and
• 4) not in pregnancy for women.

Exclusion Criteria:

• 1) had severe organic diseases,
• 2) had acute infection symptoms, allergic diseases, and malignant tumors,
• 3) had a family history of genetic diseases,
• 4) took VD supplements in the past 6 months,
• 5) took medicines to control lipid levels within 12 hours, or
• 6) took diuretics, did strenuous exercise, or overate within 24 hours before the test.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
SNPs of VDR	Polymorphisms of vitamin D receptor gene: Cdx2, Fok1, Apa1, and Taq1	6 months
lipid profiles	Serum concentrations of TG, TC, LDLC, and HDLC	6 months
25OHD	Plasma 25-hydroxyvitamin D concentration	6 months

Collaborators and Investigators

• Sponsor: Shenzhen Center for Chronic Disease Control
• Collaborators: Sun Yat-sen University

Study record dates

Study Major Dates

• Study Start (Actual): July 1, 2013
• Primary Completion (Actual): January 31, 2014
• Study Completion (Actual): October 31, 2016

Study Registration Dates

• First Submitted: January 10, 2021
• First Submitted That Met QC Criteria: January 12, 2021
• First Posted (Actual): January 13, 2021

Study Record Updates

• Last Update Posted (Actual): January 13, 2021
• Last Update Submitted That Met QC Criteria: January 12, 2021
• Last Verified: January 1, 2021

More Information

Terms related to this study

• Keywords: vitamin D; dyslipidemia; gene polymorphism; lipid; vitamin D receptor
• Additional Relevant MeSH Terms: Metabolic Diseases; Lipid Metabolism Disorders; Dyslipidemias
• Other Study ID Numbers: QLS2015

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No