Hypnosis for Chronic Idiopathic Pruritus

A Prospective Study of Hypnosis for Chronic Idiopathic Pruritus

Chronic idiopathic pruritus (CIP) is a frequent and disabling condition, for which there is no specific treatment. It was shown previously that hypnosis can relieve painful sensations. Pain and pruritus share many similarities regarding sensory receptors and pathways, suggesting that hypnosis might help relief CIP.

Study Overview

• Status: Completed
• Conditions: Chronic Idiopathic Pruritus
• Intervention / Treatment: Other: Hypnosis

Detailed Description

Chronic idiopathic pruritus (CIP) is a frequent and disabling condition, with significative impact on quality of life. At present, there is no specific treatment for CIP. Topical steroids are frequently used, with partial efficacy, and adverse effects. Hypnosis is a specific state of conscience. It differs from waking state, sleeping state, relaxation, or meditation. In this state, the person is highly responsive to suggestion. In medicine, hypnosis can be used to engage the internal resources of the person against unpleasant feelings. It was shown previously that hypnosis can relieve painful sensations. Pain and pruritus share many similarities regarding sensory receptors and pathways, suggesting that hypnosis might help relief CIP.

• Study Type: Interventional
• Enrollment (Actual): 12
• Phase: Not Applicable

Contacts and Locations

Study Locations

• France
  • Nice, France, 06000
    • CHU de Nice

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 90 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Male or female of at least 18 years at screening
• Diagnosis of chronic (at least 6 wks.) idiopathic pruritus
• Pruritus Numeric Rating Scale > = 4

Exclusion Criteria:

• Pruritus caused by a dermatological or a systemic conditions
• Suicidal crisis, moderate, or severe
• Psychosis (schizophrenia, persistent delusional disorder)
• Bipolar disorder, not stabilized or decompensating
• Personality disorder, decompensated

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: Hypnosis; hyspnosis treatment	Other: Hypnosis; Chronic idiopathic pruritus is treated by hypnosis

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change From Baseline in Pruritus Numeric Rating Scale	Assessment of the intensity of pruritis in Pruritus Numeric Rating Scal; the minimum and maximum values 0 to 10	Day 84

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change From Baseline in Pruritus Verbal Rating Scale	Assessment of Pruritus by pruritus Verbal Rating Scale; the minimum and maximum values 0 to 4	Day 84
Change From Baseline in Sleeping Scale	assessment in sleeping scale ; the minimum and maximum values 0 to 10	Day 84
Change From Baseline in DLQI scale	assessment in DLQI scale; result between 0 to 30	Day 84
Change From Baseline in HAD scale	assessment in HAD scale; result between 0 to 42	Day 84
Change From Baseline in usage of topical steroids	assessment in usage of topical steroids	Day 84
Evaluation of tolerance of hypnosis	assessment of tolerance of hypnosis with report of adverse event	Day 84

Collaborators and Investigators

• Sponsor: Centre Hospitalier Universitaire de Nice
• Investigators: Principal Investigator: BAHADORAN PHILIPPE, Centre Hospitalier Universitaire de Nice

Study record dates

Study Major Dates

• Study Start (Actual): April 13, 2021
• Primary Completion (Actual): September 13, 2021
• Study Completion (Actual): October 31, 2022

Study Registration Dates

• First Submitted: March 26, 2021
• First Submitted That Met QC Criteria: March 31, 2021
• First Posted (Actual): April 2, 2021

Study Record Updates

• Last Update Posted (Actual): January 12, 2024
• Last Update Submitted That Met QC Criteria: January 11, 2024
• Last Verified: January 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Skin Diseases; Skin Manifestations; Pruritus
• Other Study ID Numbers: 20-AOIP-01; 2020-A03263-36 (Other Identifier: CHU de Nice)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No