Investigation of the Effects of Selective Exercise Training in Multiple Sclerosis

Investigation of the Effects of Selective Exercise Training on Muscle Architecture, Balance, Function and Fatigue in Multiple Sclerosis

Sponsors

Lead Sponsor: Sanko University

Source Sanko University
Brief Summary

Selective exercise programs specific to muscle groups, with the workload to be done in line with the muscle's own structure, can enable more strength to be released with less fatigue in MS, and this increase in strength can increase balance and functional activities. to determine the effects of type training (selective exercise training), eccentric and concentric training on function, balance, fatigue and muscle architecture.

Detailed Description

Recovery and enhancement of muscle function in MS is one of the main goals in physiotherapy and rehabilitation. In literature studies, it is stated that eccentric and concentric exercises are effective exercise approaches in increasing strength and reducing fatigue. However, the best exercise method is not yet clear in terms of providing better performance adaptation with less fatigue. Considering the architectural features of the lower extremity muscles, it is aimed to increase the angle of pennation with programs that include concentric strengthening of the quadriceps, gastro-soleus and gastrocnemius muscles, which are suitable muscle groups to produce large forces by design. With programs that include eccentric strengthening of the hamstring and tibialis anterior muscles that function in a wide range of motion and have high excursion ability, it is aimed to increase fiber length.

Overall Status Completed
Start Date 2018-09-15
Completion Date 2020-06-15
Primary Completion Date 2020-04-15
Phase N/A
Study Type Interventional
Primary Outcome
Measure Time Frame
muscle architecture parameter 1 Change from Baseline at 8th weeks and 12th weeks
muscle architecture parameter 2 Change from Baseline at 8th weeks and 12th weeks
muscle architecture parameter 3 Change from Baseline at 8th weeks and 12th weeks
Muscle strength Change from Baseline at 8th weeks and 12th weeks
Secondary Outcome
Measure Time Frame
walking fatigue Change from Baseline at 8th weeks and 12th weeks
perceived fatigue Change from Baseline at 8th weeks and 12th weeks
physical fatigue Change from Baseline at 8th weeks and 12th weeks
static balance Change from Baseline at 8th weeks and 12th weeks
dynamic balance Change from Baseline at 8th weeks and 12th weeks
Functional activities 1 Change from Baseline at 8th weeks and 12th weeks
Functional activities 2 Change from Baseline at 8th weeks and 12th weeks
Functional activities 3 Change from Baseline at 8th weeks and 12th weeks
Enrollment 33
Condition
Intervention

Intervention Type: Other

Intervention Name: exercise

Description: exercise training for 8 weeks

Eligibility

Criteria:

Inclusion Criteria: - Between the ages of 18-50, - With an Extended Disability Status Scale (EDSS) score of 4 or less, - No regular exercise habit - Able to walk on the treadmill, - No pregnancy, - Not receiving corticosteroid treatment in the last month, - Fampridine etc. in the last 1 month. not taking medication, - Patients who have not received Botox treatment in the last 6 months Exclusion Criteria: patients who do not agree to volunteer

Gender:

All

Minimum Age:

18 Years

Maximum Age:

50 Years

Healthy Volunteers:

No

Overall Official
Location
Facility: Zekiye İpek Katırcı Kırmacı
Location Countries

Turkey

Verification Date

2021-04-01

Responsible Party

Type: Principal Investigator

Investigator Affiliation: Kahramanmaras Sutcu Imam University

Investigator Full Name: zekiye ipek katırcı kırmacı

Investigator Title: assistant professor

Keywords
Has Expanded Access No
Condition Browse
Number Of Arms 3
Arm Group

Label: Selective training

Type: Experimental

Description: selective training on lower extremity for 3 days/week

Label: Downhill walking

Type: Experimental

Description: downhill walking training on the treadmill for 2 days/week

Label: Uphill walking

Type: Experimental

Description: uphill walking training on the treadmill for 2 days/week

Study Design Info

Allocation: Randomized

Intervention Model: Parallel Assignment

Primary Purpose: Treatment

Masking: Double (Investigator, Outcomes Assessor)

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