Investigation of the Effects of Selective Exercise Training in Multiple Sclerosis

Investigation of the Effects of Selective Exercise Training on Muscle Architecture, Balance, Function and Fatigue in Multiple Sclerosis

Selective exercise programs specific to muscle groups, with the workload to be done in line with the muscle's own structure, can enable more strength to be released with less fatigue in MS, and this increase in strength can increase balance and functional activities. to determine the effects of type training (selective exercise training), eccentric and concentric training on function, balance, fatigue and muscle architecture.

Study Overview

• Status: Completed
• Conditions: Multiple Sclerosis; Exercise
• Intervention / Treatment: Other: exercise

Detailed Description

Recovery and enhancement of muscle function in MS is one of the main goals in physiotherapy and rehabilitation. In literature studies, it is stated that eccentric and concentric exercises are effective exercise approaches in increasing strength and reducing fatigue. However, the best exercise method is not yet clear in terms of providing better performance adaptation with less fatigue. Considering the architectural features of the lower extremity muscles, it is aimed to increase the angle of pennation with programs that include concentric strengthening of the quadriceps, gastro-soleus and gastrocnemius muscles, which are suitable muscle groups to produce large forces by design. With programs that include eccentric strengthening of the hamstring and tibialis anterior muscles that function in a wide range of motion and have high excursion ability, it is aimed to increase fiber length.

• Study Type: Interventional
• Enrollment (Actual): 33
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Turkey
  • Gaziantep, Turkey
    • Zekiye İpek Katırcı Kırmacı

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 50 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Between the ages of 18-50,
• With an Extended Disability Status Scale (EDSS) score of 4 or less,
• No regular exercise habit
• Able to walk on the treadmill,
• No pregnancy,
• Not receiving corticosteroid treatment in the last month,
• Fampridine etc. in the last 1 month. not taking medication,
• Patients who have not received Botox treatment in the last 6 months

Exclusion Criteria:

patients who do not agree to volunteer

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Selective training; selective training on lower extremity for 3 days/week	Other: exercise; exercise training for 8 weeks
Experimental: Downhill walking; downhill walking training on the treadmill for 2 days/week	Other: exercise; exercise training for 8 weeks
Experimental: Uphill walking; uphill walking training on the treadmill for 2 days/week	Other: exercise; exercise training for 8 weeks

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
muscle architecture parameter 1	The pennation angle were evaluated with Ultrasound	Change from Baseline at 8th weeks and 12th weeks
muscle architecture parameter 2	The fiber length were evaluated with Ultrasound	Change from Baseline at 8th weeks and 12th weeks
muscle architecture parameter 3	The muscle thickness were evaluated with Ultrasound	Change from Baseline at 8th weeks and 12th weeks
Muscle strength	low extremity muscles were evaluated with hand dynamometer	Change from Baseline at 8th weeks and 12th weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
walking fatigue	Walking Fatigue Index	Change from Baseline at 8th weeks and 12th weeks
perceived fatigue	Fatigue Severity Scale	Change from Baseline at 8th weeks and 12th weeks
physical fatigue	Modified Borg Scale before and after 6-minute walking test	Change from Baseline at 8th weeks and 12th weeks
static balance	Single standing tests	Change from Baseline at 8th weeks and 12th weeks
dynamic balance	4 square step tests	Change from Baseline at 8th weeks and 12th weeks
Functional activities 1	timed-up go test	Change from Baseline at 8th weeks and 12th weeks
Functional activities 2	2-minute walk test	Change from Baseline at 8th weeks and 12th weeks
Functional activities 3	25-feet walk test	Change from Baseline at 8th weeks and 12th weeks

Collaborators and Investigators

• Sponsor: Sanko University
• Investigators: Study Director: TÜZÜN FIRAT, Hacettepe University; Study Chair: AYHAN ÖZKUR, SANKO University; Study Chair: AYŞE MÜNİFE NEYAL, SANKO University; Study Chair: ABDURRAHMAN NEYAL, Dr. Ersin Arslan Training and Research Hospital,; Study Director: NEVİN ERGUN, SANKO University

Study record dates

Study Major Dates

• Study Start (Actual): September 15, 2018
• Primary Completion (Actual): April 15, 2020
• Study Completion (Actual): June 15, 2020

Study Registration Dates

• First Submitted: April 11, 2021
• First Submitted That Met QC Criteria: April 18, 2021
• First Posted (Actual): April 21, 2021

Study Record Updates

• Last Update Posted (Actual): January 13, 2022
• Last Update Submitted That Met QC Criteria: December 27, 2021
• Last Verified: December 1, 2021

More Information

Terms related to this study

• Keywords: multiple sclerosis; muscle architecture; Eccentric Exercise; Concentric Exercise
• Additional Relevant MeSH Terms: Pathologic Processes; Nervous System Diseases; Immune System Diseases; Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Demyelinating Diseases; Autoimmune Diseases; Multiple Sclerosis; Sclerosis
• Other Study ID Numbers: ipekkirmaci

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No