Study on the Effect of Selenium Supplementation on the Structure and Function of Autoimmune Thyroiditis

Study on the Effect of Selenium Supplementation on the Structure and Function of Autoimmune Thyroiditis

Sponsors

Lead Sponsor: Beijing Chao Yang Hospital

Source Beijing Chao Yang Hospital
Brief Summary

To evaluate the effects of exogenous selenium supplementation on autoimmune thyroiditis.

Detailed Description

In patients with autoimmune thyroiditis, investigators compared changes in thyroid function, anti-thyroid peroxidase antibody, anti-thyroglobulin antibody, thyroid magnetic resonance T1-mapping values and metabolic indicatorsfrom baseline to the end of treatment (12 weeks)

Overall Status Recruiting
Start Date 2019-12-20
Completion Date 2021-10-30
Primary Completion Date 2021-07-30
Phase N/A
Study Type Interventional
Primary Outcome
Measure Time Frame
anti-thyroglobulin antibody changes Changes from baseline and 3 months during follow-up
T1-mapping values of Thyroid MRI Changes from baseline and 3 months during follow-up
Enrollment 30
Condition
Intervention

Intervention Type: Drug

Intervention Name: Selenium

Description: selenium 100ug ,take it orally twice daily

Arm Group Label: selenium

Eligibility

Criteria:

Inclusion Criteria: - Men or women between the ages of 18 and 75 - Clinical diagnosis of autoimmune thyroiditis, serum TPOAb and TGAB positive - Thyroid function is normal, and no drugs affecting thyroid function such as Umetole and Serge have been used Exclusion Criteria: - The contraindications indicated in the Chinese instructions of the drug - Hypothyroidism, hyperthyroidism - Liver function impairment - Renal function impairment - Claustrophobia - Mental disorders

Gender:

All

Minimum Age:

18 Years

Maximum Age:

75 Years

Healthy Volunteers:

No

Overall Official
Last Name Role Affiliation
Guang Wang Principal Investigator Beijing Chao Yang Hospital
Overall Contact

Last Name: Jia Liu, MD

Phone: 861085231710

Email: [email protected]

Location
Facility: Status: Contact: Beijing Chao-Yang Hospital, Capital Medical University Jia liu, MD 861085231710 [email protected]
Location Countries

China

Verification Date

2021-07-01

Responsible Party

Type: Principal Investigator

Investigator Affiliation: Beijing Chao Yang Hospital

Investigator Full Name: Guang Wang

Investigator Title: Professor and Director, Department of Endocrinology

Has Expanded Access No
Condition Browse
Number Of Arms 1
Arm Group

Label: selenium

Type: Experimental

Description: selenium was administered to patients with autoimmune thyroiditis

Study Design Info

Allocation: N/A

Intervention Model: Single Group Assignment

Intervention Model Description: patients with Autoimmune thyroiditis

Primary Purpose: Treatment

Masking: None (Open Label)

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