An MRI Study of the Sniffing, Neutral and Extended Head and Neck Positions

August 23, 2024 updated by: University Hospitals Coventry and Warwickshire NHS Trust

A Magnetic Resonance Imaging Study of Changes in the Angle Between the Tracheal and Laryngeal Axes in the Sniffing, Neutral and Extended Head and Neck Positions for Videolaryngoscopy

The traditional method of tracheal intubation requires the insertion of a laryngoscope into the oral cavity and directly visualisation of the glottis. The traditional head position called the sniffing the morning air position; consisting of lower cervical flexion and extension of the atlanto-occipital joint is commonly used to facilitate tracheal intubation in this manner by aligning the oral axes and providing the operator a view of the glottis.

With the advancement of technology, has seen videolaryngoscopes (VL) developed to ease tracheal intubation. With VL, the glottis is seen through a camera connected to a viewing screen either attached to the top of the laryngoscope or connected to a camera screen by cable. One of the main drawbacks with VL is that a good view of the glottis is seen on the screen, but it can be difficult to pass the tracheal tube through the glottis in comparison to the traditional intubation technique described above. One of the main factors the authors suggest is that VL-assisted intubation requires a head and neck position that is different to the sniffing the morning air position.

This study aims to assess the oral axes in three different head and neck positions under MRI to assess which positions improve axial alignment the most.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

The traditional method of tracheal intubation requires the insertion of a laryngoscope with the left hand into the oral cavity to displace the tongue and directly visualise the glottis.

The sniffing the morning air (or sniffing) position has been traditionally used for tracheal intubation using direct laryngoscopy. This comprises of flexion of the lower cervical spine, extension at the atlanto-occiptal joint and a horizontal level between the tragus of the ear and sternum. The theoretical purpose of this position is to improve the glottic visualisation by aligning the oral, pharyngeal and tracheal axes.

In recent years with the advancement of technology, videolaryngoscopy has become popular and many centres are now using only videolaryngoscopes for tracheal intubation. Visualisation occurs indirectly through fibreoptic or digital channels. Most videolaryngoscopes use two types of blades. The Macintosh type for normal airway and hyper-angulated blade for difficult airway.

Hyperangulated blades such as the Glidescope LoPro (Verathon Inc, Bothwell, WA, USA), McGrath Series 5 X blade (Medtronic, Minneapolis, MN, USA) and Storz C-Mac D-blade (Karl Storz Endoscoke, Tuttlingen, Germany) are more curved than the traditional standard geometry used with direct laryngoscopy and are thought to improve glottis visualisation without significant change in head position. However, visualisation of glottis is one of the three steps involved in videolaryngoscopy assisted tracheal intubation. The other two steps include aligning the tube with the glottic inlet and advancing the tube through the glottis into the trachea.

One of the main drawbacks in videolaryngoscopy is that despite good view of glottis on the screen, it can be difficult to successfully advance the tracheal tube into the trachea. Anterior impingement of the tracheal tube at the sub-glottic region is a recognised problem with hyperangulated and channelled videolaryngoscopes. VL directs the pre-formed tracheal tube anteriorly but the trachea descends posteriorly into the thorax creating an acute angle impeding passage of the tube. This can result in difficult intubation or a failed intubation. Manoeuvres such as tube rotation and rotation of bougie can rectify this problem to some extent.

A previous study found that laryngoscopy was more difficult with hyper-angulated blades in the sniffing position as compared to neutral position, contradictory to traditional laryngoscopy teaching. Intermediary positions between sniffing and supine should be studied as these may balance the needs of maintaining sufficient mouth opening and not hindering angles affecting the axial alignment. Both studies recommend the benefits of a ramped position as it does reduce the time to desaturation and reduces aspiration risk compared to supine neutral positions and should be considered when using hyperangulated blades. .

Using magnetic resonance imaging in awake and healthy patients, Adnet, et al. measured the oral, pharyngeal and tracheal axes using the neutral position, sniffing position and simple head extension and found neither position resulted in perfect alignment of the 3 axes. However, they did not study the effect of position on angle between tracheal and laryngeal axes. The search for further evidence is necessary for VL as there is a paucity of research in with regard to best head and neck position for videolaryngoscopy.

Study Type

Interventional

Enrollment (Actual)

20

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United Kingdom
    • West Midlands
      • Coventry, West Midlands, United Kingdom, CV2 2DX
        • University Hospitals Coventry & Warwickshire NHS Trust

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Able to provide consent
  • Volunteers, UHCW staff, aged > 18 years
  • Medically able and willing undertake MRI scanning.
  • Should pass the MRI safety check list to enter the MRI suite. All participants will complete an MR safety questionnaire immediately prior to their MR scan

Exclusion Criteria:

  • Unable to provide consent
  • Not willing to have MRI scan or unable to undergo MRI scanning
  • Known difficult intubation, Restricted or neck extension not possible or presence of arthritis of cervical spine.
  • For MRI safety reasons all participants with a cardiac pacemaker or other electronic implants will be excluded from the study.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Data collection
All 20 anticipated subjects to be scanned under MRI, with data collected and analysed together
Diagnostic test: Data collection group

Magnetic resonance imaging (MRI) allows measurement of the axes described to suggest which head and neck position would provide best anatomical alignment to reduce anterior impingement.

All the MRI scans will be conducted using 3.0 Tesla (Optima 750w, GE Medical, Milwaukee, WI, USA) using the cervical spine section of the coil. T2-weighted images in the sagittal plane will be acquired using a fast recovery fast spin echo (FRFSE) technique. The scans will take around two and half minutes and a member of the anaesthetic investigator team will be present to facilitate positional changes and maintain consistency. MRI scanning will be performed in following 3 head and neck positions:

Neutral position, Sniffing position and the Extension position.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Angle A Measured on MRI
Time Frame: Each subject will undergo 3 MRI scans. Angle A will be measured on each scan at the end of all the scans performed that day. The angles will be measured by 2 investigators.
To determine which patient head and neck positioning significantly improves the angle A. It is defined as the angle between the tracheal axis (TA) and laryngeal axis (LA)
Each subject will undergo 3 MRI scans. Angle A will be measured on each scan at the end of all the scans performed that day. The angles will be measured by 2 investigators.

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Angle B, C, D and E Measured Using MRI
Time Frame: Each subject will undergo 3 MRI scans. The angles will be measured on each scan at the end of the scanning performed that day. The angles will be measured by 2 investigators.

The tracheal axis (TA) is defined as a line passing through the centre of intrathoracic part of trachea to the centre of cricoid cartilage. The laryngeal axes (LA) is defined as a line passing through the centre of cricoid cartilage to the base of the epiglottis. The pharyngeal axis (PA) is defined as a line passing through the anterior portion of the atlas and vertebrae C2. The oral axis (OA) is defined as straight line drawn parallel to the hard palate. The line of vision (LV) is defined as the straight line passing through the inferior extremity of the superior incisors and posterior extremity of the superior portion of the cricoid.

Angle B is angle between the laryngeal axes (LA) and pharyngeal axes (LA) Angle C is angle between pharyngeal axes (PA) and oral axes (OA) Angle D angle between laryngeal axes (LA) and line of vision (LV) Angle E angle between line of vision (LV) and pharyngeal axes (PA)
Each subject will undergo 3 MRI scans. The angles will be measured on each scan at the end of the scanning performed that day. The angles will be measured by 2 investigators.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University Hospitals Coventry and Warwickshire NHS Trust

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

August 5, 2021

Primary Completion (Actual)

October 21, 2021

Study Completion (Actual)

October 21, 2021

Study Registration Dates

First Submitted

August 4, 2021

First Submitted That Met QC Criteria

August 11, 2021

First Posted (Actual)

August 12, 2021

Study Record Updates

Last Update Posted (Actual)

August 28, 2024

Last Update Submitted That Met QC Criteria

August 23, 2024

Last Verified

June 1, 2024

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 282078

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Intubation, Intratracheal

Clinical Trials on Data collection group

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Liberia

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

Subscribe